A5023829835- Immune Response and Inflammation
- Orthopaedic implants and arthroplasty
- Diet, Metabolism, and Disease
- Total Knee Arthroplasty Outcomes
- Bone Metabolism and Diseases
- Adipose Tissue and Metabolism
- Erythrocyte Function and Pathophysiology
- Galectins and Cancer Biology
- Ginkgo biloba and Cashew Applications
- Bone health and osteoporosis research
- Diet and metabolism studies
- dental development and anomalies
- Cell Adhesion Molecules Research
- interferon and immune responses
- Metabolism and Genetic Disorders
- Dermatologic Treatments and Research
- Drug Transport and Resistance Mechanisms
- Psidium guajava Extracts and Applications
- Muscle metabolism and nutrition
- S100 Proteins and Annexins
- Folate and B Vitamins Research
- Stress Responses and Cortisol
- Toxin Mechanisms and Immunotoxins
- Microbial Metabolites in Food Biotechnology
- Ubiquitin and proteasome pathways
BioTeSys (Germany)
2019-2024
CeramTec (Germany)
2023
Universität Ulm
2018-2021
American Journal Experts (United States)
2018
Helmholtz-Institute Ulm
2018
University Hospital Ulm
2018
Significance Our results show that one single systemic administration of the β-adrenoreceptor blocker propranolol prior to femur osteotomy in psychosocially stressed mice prevents stress-induced bone marrow mobilization neutrophils and their immigration into early fracture hematoma, as well decrease bending stiffness bony bridging callus, which indicated a compromised healing mice. These findings offer possibilities for clinical translation patients suffering from posttraumatic stress...
Abstract The anaphylatoxin C5a is generated upon activation of the complement system, a crucial arm innate immunity. mediates proinflammatory actions via receptor C5aR1 and thereby promotes host defence, but also modulates tissue homeostasis. There evidence that C5a/C5aR1 axis critically involved both in physiological bone turnover inflammatory conditions affecting bone, including osteoarthritis, periodontitis, fractures. induces migration secretion cytokines osteoblasts. However, underlying...
As an essential nutrient, the organic water-soluble compound choline is important for human health. Choline required numerous biological processes, including synthesis of neurotransmitters, and it prerequisite structural integrity functioning cells. A choline-rich diet provides crucial sources, yet additional dietary supplements might be needed to fully meet body’s requirements. Dependent on structure in different absorption metabolism may differ strongly impact bioavailability circulating...
Infections of the respiratory system, including common cold and influenza, are affecting people worldwide more or less prone to spread depending on season viral load host. For reducing symptoms duration illness, treatment options standard prescribed drugs in demand. Natural products could provide immune-supporting alternatives. Elderberry extracts have been used traditional medicine for infections decades numerous studies describe beneficial effects elderberries immune system infectious...
β-Caryophyllene (BCP), a common constituent of many spice and food plants, is gaining increased attention due to recent research identifying numerous potential health benefits. Due limited oral bioavailability observed in preclinical models, the described benefits BCP may be maximized by using suitable delivery system. Additionally, human pharmacokinetics (PK) remain unknown. This study evaluates relative formulated self-emulsifying drug system (SEDDS) based on VESIsorb® formulation...
Collagen hydrolysates (CH) in functional foods and supplements are dietary sources of amino acids (AAs) di-and tripeptides linked to various health benefits. This study aimed investigate the single-dose bioavailability skin- hide-derived CH from fish, porcine bovine origin with different molecular weights (bovine 2,000 5,000 Da).
The terminal complement complex (TCC) is formed on activation of the system, a crucial arm innate immunity. TCC formation cell membranes results in transmembrane pore leading to lysis. In addition, sublytic concentrations can modulate various cellular functions. TCC-induced effects may play role pathomechanisms inflammatory disorders bone, including rheumatoid arthritis and osteoarthritis. this study, we investigated effect bone turnover repair. Mice deficient for component 6 (C6), an...
Image artifacts caused by metal knee implants in 1.5T and 3T magnetic resonance imaging (MRI) systems complicate imaging-based diagnosis of the peri-implant region after total arthroplasty. Alternatively, metal-free prostheses could effectively minimize MRI safety hazards offer potential for higher quality diagnostic images.A novel arthroplasty device composed BIOLOX delta, an alumina matrix composite (AMC) ceramic, was tested a (MR) environment. American Society Testing Materials test...
Objective: Skin health, skin appearance and beauty are influenced by collagen composition of the dermis. Natural aging affects structural integrity network, resulting in drier skin, wrinkle formation reduced elasticity. Orally ingested hydrolyzed reaches tissue exerts beneficial effects on human from within. However, not only peptides, but also micronutrients can beneficially affect appearance. Thus, dietary supplements for cosmetic containing combinations peptides selected demand. Aim this...
The plant Santa herba (Eriodictyon californicum) contains high flavonoids, thus potentially exerting beneficial effects in context of obesity, often accompanied by inflammation and metabolic imbalance. study assessed the impact on oxidative stress, energy metabolism, weight reduction, eating behavior, combining vitro models with clinical data. binding adenosine receptor A2A (ADORA2A) was using a radioligand assay. A Caenorhabditis elegans model used to determine mobility boosting effects,...
Periodontitis is the inflammatory destruction of tooth-surrounding and -supporting tissue, resulting at worst in tooth loss. Another locally aggressive disease oral cavity resorption (TR). This associated with dental mineralized tissue. However, underlying pathomechanisms remain unknown. The complement system, as well mast cells (MCs), are known to be involved osteoclastogenesis bone factors C3 C5 were previously identified key players periodontal disease. Therefore, we hypothesize that MCs...
Background: Nutraceuticals containing hydroxytyrosol have been shown to exert a wide range of beneficial effects on the cardiovascular system like lipid modification and cholesterol reduction. The aim this randomized doubleblind, placebo-controlled parallel study was investigate pure, synthetic form (HTEssence®) profile in subjects with elevated LDL-cholesterol level. Methods: 92 underwent 12-week intervention or placebo. At baseline, after 6 12 weeks assessed.The conducted accordance...
Ten percent of patients undergoing total hip arthroplasty (THA) require revision surgery. One the reasons for THA are wear particles released from implants that can activate immune defense and cause osteolysis failure joint implant. The discrepancies between reports on toxicity immunogenicity implant materials led us to this study in which we compared well-defined nanoparticles Al2O3, zirconia-toughened alumina (ZTA), cobalt chrome (CoCr), a human THP-1 macrophage cell line, PBMCs,...