A5084154890- Bone Metabolism and Diseases
- S100 Proteins and Annexins
- Bone Tissue Engineering Materials
- Layered Double Hydroxides Synthesis and Applications
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Ubiquitin and proteasome pathways
- Synthesis and bioactivity of alkaloids
- Bone health and treatments
- interferon and immune responses
- Ion channel regulation and function
- Cell Adhesion Molecules Research
- Nicotinic Acetylcholine Receptors Study
- Bone health and osteoporosis research
- Magnesium Oxide Properties and Applications
- Estrogen and related hormone effects
- Reproductive System and Pregnancy
- Bone fractures and treatments
Universität Ulm
2018-2022
American Journal Experts (United States)
2018
Helmholtz-Institute Ulm
2018
University Hospital Ulm
2018
Patients with multiple injuries frequently suffer bone fractures and are at high risk to develop fracture healing complications. Because of its key role both in systemic posttraumatic inflammation healing, the pleiotropic cytokine interleukin-6 (IL-6) may be involved pathomechanisms trauma-induced compromised healing. IL-6 signals transmitted by two different mechanisms: classic signaling via membrane-bound receptor (mIL-6R) trans-signaling soluble form (sIL-6R). Herein, we investigated...
ABSTRACT Osteoporosis is a systemic metabolic skeletal disease characterized by low bone mass and strength associated with fragility fractures. Oxidative stress, which results from elevated intracellular reactive oxygen species (ROS) arises in the aging organism, considered one of critical factors contributing to osteoporosis. Mitochondrial (mt)ROS, as superoxide anion (O2−) generated during mitochondrial respiration, are eliminated young organism antioxidant defense mechanisms, including...
Abstract The anaphylatoxin C5a is generated upon activation of the complement system, a crucial arm innate immunity. mediates proinflammatory actions via receptor C5aR1 and thereby promotes host defence, but also modulates tissue homeostasis. There evidence that C5a/C5aR1 axis critically involved both in physiological bone turnover inflammatory conditions affecting bone, including osteoarthritis, periodontitis, fractures. induces migration secretion cytokines osteoblasts. However, underlying...
Mast cells may contribute to osteoporosis development, because patients with age-related or post-menopausal exhibit more mast in the bone marrow, and mastocytosis frequently suffer from osteopenia. We previously showed that crucially regulated osteoclastogenesis loss ovariectomized, estrogen-depleted mice a preclinical model for found granular cell mediators were responsible these estrogen-dependent effects. However, role of key regulator osteoclastogenesis, namely, receptor activator NFκB...
Alterations in bone strength and structure were found knockout (KO) mouse strains with deletion of several acetylcholine receptors. Interestingly, the expression nicotinic receptors (nAChR) subunit α10 was down-regulated osteogenic differentiated mesenchymal stem cells patients osteoporosis whereas α9 not altered. Since nAChR subunits are often combined a functional receptor, we analyzed here adult female KO mice single either alpha9 (α9KO) or alpha10 (α10KO). Biomechanical testing showed...
The terminal complement complex (TCC) is formed on activation of the system, a crucial arm innate immunity. TCC formation cell membranes results in transmembrane pore leading to lysis. In addition, sublytic concentrations can modulate various cellular functions. TCC-induced effects may play role pathomechanisms inflammatory disorders bone, including rheumatoid arthritis and osteoarthritis. this study, we investigated effect bone turnover repair. Mice deficient for component 6 (C6), an...