Salutaridinol 7-<i>O</i>-acetyltransferase (EC 2.3.1.150) catalyzes the conversion of phenanthrene alkaloid salutaridinol to salutaridinol-7-<i>O</i>-acetate, immediate precursor thebaine along morphine biosynthetic pathway. We have isolated a cDNA clone that corresponds internal amino acid sequences native enzyme purified from cell suspension culture opium poppy <i>Papaver somniferum</i>. The recombinant acetylated 7-hydroxyl moiety in presence acetyl-CoA. apparent <i>K</i> _m...

Melleolides and related fungal sesquiterpenoid aryl esters are antimicrobial cytotoxic natural products derived from cultures of the Homobasidiomycetes genus <i>Armillaria</i>. The initial step in biosynthesis all melleolides involves cyclization universal sesquiterpene precursor farnesyl diphosphate to produce protoilludene, a reaction catalyzed by protoilludene synthase. We achieved partial purification synthase mycelial culture <i>Armillaria gallica</i> found that 6-protoilludene was its...

Purslane extract (PE) is derived from Portulaca oleracea L., a medicinal plant used in traditional medicine for its antidiabetic properties. This randomized, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PE improving glucose control, blood pressure, lipid profile adults with type 2 diabetes mellitus (T2DM) treated single oral hypoglycemic agent at baseline. Subjects were randomized treatment three capsules PE/day or matched placebo. Change baseline...

Abstract Aging is driven by fundamental mechanisms like oxidative stress, telomere shortening and changes in DNA methylation, which together prepare the ground for age-related diseases. Botanical extracts, rich bioactive phytoconstituents, represent a promising resource developing therapies that target these to promote healthy aging. This study explores geroprotective potential of Monarda didyma L. extract. In vitro analyses revealed extract’s strong antioxidant activity, ability reduce...

The complex process of skin aging results in noticeable changes, including decreased collagen content, reduced elasticity, and hydration. Interventions to preserve or restore collagen, a key structural protein, may help counteract these signs. concept "beauty from within” through nutritional supplements is growing interest, particularly the use plant-based alternatives animal-derived synthetic collagen. This study investigated anti-aging potential an extract Moldavian dragonhead...

Objectives: A wild green-oats extract (Neuravena®) containing a range of potentially bioactive components, including flavonoids and triterpene saponins, has previously been shown to enhance animal stress responses memory, improve cognitive performance in humans at dose 1600 mg.Methods This double-blind, placebo-controlled, counterbalanced cross-over study assessed the effects single doses green-oat (GOE) across broad domains healthy adults aged 40–65 years who self-reported that they felt...

Abstract Melleolides and armillyl orsellinates are protoilludene-type aryl esters that synthesized exclusively by parasitic fungi of the globally distributed genus Armillaria (Agaricomycetes, Physalacriaceae). Several these compounds show potent antimicrobial cytotoxic activities, making them promising leads for development new antibiotics or drugs treatment cancer. We recently cloned characterized gallica gene Pro1 encoding protoilludene synthase, a sesquiterpene cyclase catalyzing...

Background: Zanthoxylum armatum DC. (ZA) is a traditional Asian culinary spice and medicinal compound, which rich in monoterpenes hydroxy α-sanshool. Mechanistic interactions with the monoamine, cholinergic cannabinoid neurotransmission systems, as well transient receptor potential (TRP) potassium ion channels, may predispose ZA to modulate human brain function. Objectives: To investigate effects of single dose 56-days supplementation lipid extract on cognitive function, mood cerebral...

Hair loss affects millions of people worldwide, but currently available treatment options are often dissatisfying due to side effects or limited efficacy. Pea sprout extract has been shown improve hair density when applied topically, its mode action and effectiveness upon oral administration remain unknown. Our study now that the application a fluid containing 2% pea on defined scalp zone 10 volunteers enhances expression genes relevant for hair, namely fibroblast growth factor‐7 (FGF7)...

The global increase in life expectancy has led to a growing elderly population, which places significant burden on healthcare systems. As result, there is interest improve healthspan and promote healthy aging with accessible means, such as nutrition lifestyle interventions. skin, the body's largest organ first line of defense against environmental stressors, particularly vulnerable due both intrinsic extrinsic factors. Various molecular biochemical changes can drive skin aging, including...

The plant Santa herba (Eriodictyon californicum) contains high flavonoids, thus potentially exerting beneficial effects in context of obesity, often accompanied by inflammation and metabolic imbalance. study assessed the impact on oxidative stress, energy metabolism, weight reduction, eating behavior, combining vitro models with clinical data. binding adenosine receptor A2A (ADORA2A) was using a radioligand assay. A Caenorhabditis elegans model used to determine mobility boosting effects,...

The skin is primarily affected by aging, especially when it exposed to particulate matter present in the environment. It has been hypothesized that consumption of products with known antioxidant properties would help combat factors associated both intrinsic and extrinsic aging factors.The aim study was evaluate effect formulation Blue Fenugreek Kale Extract (BFKE) on aging.In this study, BFKE protein oxidation determined human dermal fibroblasts analysis level carbonylation after cells were...

Investigations into human longevity are increasingly focusing on healthspan enhancement, not just lifespan extension. Lifestyle modifications and nutritional choices, including food supplements, can significantly affect aging general health. Phytochemicals in centenarians’ diets, such as those found Timut pepper, a Nepalese spice with various medicinal properties, may contribute to their longevity. Similarly, Sichuan related species, has demonstrated anti-inflammatory neuroprotective...

Abstract For see ChemInform in Full Text.

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”