Abstract Background Aging represents a serious health and socioeconomic concern for our society. However, not all people age in the same way air pollution has been shown to largely impact this process. We explored whether polycyclic aromatic hydrocarbons (PAHs), excellent fossil wood burning tracers, accelerate biological aging detected by lymphocytes DNA methylation (DNAmAge) telomere length (TL), early nuclear (nDNA) hallmarks of non-mitotic mitotic cellular aging, mitochondrial copy...

DNA methylation (DNAm) is an emerging estimator of biological aging, i.e., the often-defined "epigenetic clock", with a unique accuracy for chronological age estimation (DNAmAge). In this pilot longitudinal study, we examine hypothesis that intensive relaxing training 60 days in patients after myocardial infarction and healthy subjects may influence leucocyte DNAmAge by turning back epigenetic clock. Moreover, compare another mechanism age, telomere length (LTL) telomerase. reduced (p =...

An innovative approach for cancer therapy implies the use of drugs covalently conjugated to macromolecular carriers that specifically target molecules over-expressed on tumor cells. This drug delivery strategy may allow a controlled release and high targeting selectivity cells, increasing cytotoxicity decreasing its undesirable side effects. We provide in vitro vivo preclinical data antitumor efficacy ONCOFID™-S, new bioconjugate hyaluronic acid (HA) with SN-38 (the CPT11 active metabolite),...

Abstract Chronological age represents the main factor in donor selection criteria for organ transplantation, however aging is very heterogeneous. Defining biological of individual organs may contribute to supporting this process. In study we examined heart [right (RA)/left atrium (LA)] and peripheral blood leucocytes same subject, compared these assess whether mirrors cardiac aging. Biological was studied 35 donors (0.4–72 years) by exploring mitotic non-mitotic pathways, using telomere...

Abstract Background Further knowledge on modifiable aging risk factors is required to mitigate the increasing burden of age-related diseases in a rapidly growing global demographic elderly individuals. We explored effect everyday exposure polycyclic aromatic hydrocarbons (PAHs), which are fundamental constituents air pollution, cellular biological aging. This was determined via analysis leukocyte telomere length (LTL), mitochondrial DNA copy number (LmtDNAcn), and by formation...

Astronauts returning from space missions often exhibit health issues mirroring age-related conditions, suggesting spaceflight as a potential driver of biological ageing and diseases. To unravel the underlying mechanisms these this comprehensive review explores impact "exposome" on twelve hallmarks ageing. Through meticulous analysis encompassing both environments terrestrial analogs, we aim to decipher how different conditions influence hallmarks. Utilizing PubMed, identified 189 studies 60...

Sarcopenia, a musculoskeletal disease characterized by the progressive loss of skeletal muscle mass, strength, and physical performance, presents significant challenges to global public health due its adverse effects on mobility, morbidity, mortality, healthcare costs. This comprehensive review explores intricate connections between sarcopenia low birth weight (LBW), emphasizing developmental origins (DOHaD) hypothesis, inflammatory processes (inflammaging), mitochondrial dysfunction,...

Aging is an emerging worldwide threat to public health, even in the workplace, as it links with risk of illness and death. Bewildered inflammatory responses stressful conditions associate age-related disorders. Additionally, circadian rhythm disruption, a critical health issue night-shift workers, correlates premature aging. We investigated hypothesis link between altered response, detected by plasmatic long pentraxin 3 (PTX3), biological aging, measured leucocyte telomere length (LTL),...

Histochemical and ultrastructural investigations were conducted on the mucous cells of intestine brown trout, Salmo trutta L., naturally infected with cestode Cyathocephalus truncatus (Pallas, 1781) acanthocephalan Echinorhynchus truttae Shrank, 1788. A subpopulation 45 S. examined which 15 specimens harboured E. truttae, C. fish, control group, uninfected. In histological sections, hyperplasia hypertrophy evident at site parasite infection. Enhanced mucus secretion was also recorded in...

Abstract Aging is driven by fundamental mechanisms like oxidative stress, telomere shortening and changes in DNA methylation, which together prepare the ground for age-related diseases. Botanical extracts, rich bioactive phytoconstituents, represent a promising resource developing therapies that target these to promote healthy aging. This study explores geroprotective potential of Monarda didyma L. extract. In vitro analyses revealed extract’s strong antioxidant activity, ability reduce...

The biological age of an organ may represent a valuable tool for assessing its quality, especially in the elder. We examined kidneys [right (RK) and left kidney (LK)] blood leukocytes same subject compared these to assess whether mirrors aging. Biological was studied n = 36 donors (median age: 72 years, range: 19-92; male: 42%) by exploring mitotic non-mitotic pathways, using telomere length (TL) age-methylation changes (DNAmAge) acceleration (AgeAcc). RK LK DNAmAge are older than (RK vs....

Sleep deprivation and the consequent circadian clock disruption has become an emergent health question being associated with premature aging earlier chronic diseases onset. Night-shift work leads to misalignment, which is linked several age-related diseases. However, mechanisms of this association are not well understood. Aim study explore in night-shift workers early indicators oxidative stress response biological [oxidized/methylated DNA bases leukocytes telomere length (LTL)] late...

Coke oven workers are exposed to both free and particle bound PAH. Through this exposure, the may be at increased risk of cardiovascular diseases. Systemic levels acute phase response proteins have been linked disease in epidemiological studies, suggesting it as a marker these conditions. The aim study was assess whether there association between PAH exposure blood level inflammatory serum amyloid A (SAA) coke workers. total 87 male Polish from two different plants comprised population....

Leukocyte telomere length (LTL) represents a key integrating component of the cumulative effects environmental, lifestyle, and genetic factors. A question, however, remains on whether LTL can be considered predictive for longer healthier life. Within elderly prospective TRELONG cohort (n = 612), we aimed to investigate as predictor longevity identify main determinants among many different factors (physiological lifestyle characteristics, physical performance frailty measures, chronic...

Background/objectives: The pathologic relationship linking obesity and lipid dismetabolism with earlier onset of aging-related disorders, including cardiovascular disease (CVD) type-2 diabetes (T2D), is not fully elucidate. Chronic inflammatory state, in obese individuals, may accelerate cellular ageing. However leukocytes telomere length (LTL), the biological aging indicator, elusively linked obesity. Recent studies indicate that sterol 27-hydroxylase (CYP27A1) an emerging antiatherogenic...

The growing phenomenon of population aging is redefining demographic dynamics, intensifying age-related conditions, especially dementia, projected to triple by 2050 with an enormous global economic burden. This study investigates visual arts-mediated Cognitive Activation Therapy (CAT) as a non-pharmacological CAT intervention targets both biological [leukocyte telomere length (LTL), DNA methylation age (DNAmAge)] and cognitive functionality. Aligning broader trend integrating approaches into...

This study explores the role of inflammation and oxidative stress, hallmarks COVID-19, in accelerating cellular biological aging. We investigated early molecular markers—DNA methylation age (DNAmAge) telomere length (TL)—in blood leukocytes, nasal cells (NCs), induced sputum (IS) one year post-infection pauci- asymptomatic healthcare workers (HCWs) infected during first pandemic wave (February–May 2020), compared to COPD patients, model for “aged lung”. Data from questionnaires, Work Ability...

: Telomere length (TL) maintenance plays an important role in bladder cancer (BC) and prognosis. However the manifold influence of everyday life exposures genetic traits on leucocyte TL (LTL), is not fully elucidated.

Aging is the predominant risk factor for most degenerative diseases, including chronic obstructive pulmonary disease (COPD). This process however very heterogeneous. Defining biological aging of individual tissues may contribute to better assess this risky process. In study, we examined age induced sputum (IS) cells, and peripheral blood leukocytes in same subject, compared these whether mirrors that IS cells. Biological was assessed 18 COPD patients (72.4 ± 7.7 years; 50% males). We...

This study explores the role of inflammation and oxidative stress, hallmarks COVID-19, in accelerating cellular biological aging. We investigated early molecular markers—DNA methylation age (DNAmAge) telomere length (TL)—in blood leukocytes, nasal cells (NC), induced sputum (IS) one-year post-infection pauci- asymptomatic healthcare workers (HCWs) infected during first pandemic wave (February-May 2020), compared to COPD patients, model for "aged lung". Data by...

Abstract A neurogenic pathway, involving airway TRPV-1, has been implicated in acute cardiovascular events occurring after peaks of air pollution. We tested whether inhaled prostaglandin-E 2 (PGE ) and bradykinin (BK) regulate TRPV-1 activity vivo by changing cough response to capsaicin (CPS) affecting heart rate variability (HRV), while also taking into account the influence polymorphisms (SNPs). Moreover, we assessed molecular mechanism modulation vitro. Seventeen healthy volunteers 100 μg...