A5100408458- Mathematical Biology Tumor Growth
- Caveolin-1 and cellular processes
- Cancer Immunotherapy and Biomarkers
- Bone Metabolism and Diseases
- Zebrafish Biomedical Research Applications
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Congenital heart defects research
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- ATP Synthase and ATPases Research
- Viral Infections and Immunology Research
- IL-33, ST2, and ILC Pathways
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Cytokine Signaling Pathways and Interactions
- Cell Adhesion Molecules Research
- Antimicrobial Resistance in Staphylococcus
- Pancreatitis Pathology and Treatment
- Bacterial Identification and Susceptibility Testing
- Nanoplatforms for cancer theranostics
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
Chongqing Medical University
2025
Tianjin Medical University General Hospital
2025
Hubei University of Technology
2024
University of Michigan
2023-2024
Union Hospital
2023-2024
Huazhong University of Science and Technology
2023-2024
Ningxia Medical University
2024
University of California, Los Angeles
2020-2024
Texas Medical Center
2022
Houston Methodist
2022
Abstract MicroRNAs (miRNAs) interfere with the translation of specific target mRNAs and are thought to thereby regulate many cellular processes. However, role miRNAs in osteoblast mechanotransduction remains be defined. In this study, we investigated ability a miRNA respond different mechanical environments mechano-induced differentiation. First, demonstrated that miR-33-5p expressed by osteoblasts is sensitive multiple environments, microgravity fluid shear stress. We then confirmed promote...
Improving glioma treatment effectiveness requires a thorough understanding of gliomagenesis. Emerging evidences have proved that zinc and ring finger 2 (ZNRF2) contributes to development various human malignancies. Nevertheless, comprehensive study ZNRF2's role in is absent currently. Utilizing open resources from Chinese Glioma Genome Atlas (CGGA), Gene Expression Omnibus (GEO), The Cancer (TCGA), Connectivity Map (cMap) other bioinformatic tools, we systematically examined the expression,...
How do vessels find optimal radii? Capillaries are known to adapt their radii maintain the shear stress of blood flow at vessel wall a set point, yet models adaptation purely based on average have not been able produce complex loopy networks that resemble real microvascular systems. For narrow where red cells travel in single file, endothelium peaks sharply when cell passes through. We show stable shear-stress-based is possible if points cued peaks. Model respond peak stresses alone can...
Bladder cancer is an increasingly prevalent global disease that continues to cause morbidity and mortality despite recent advances in treatment. Immune checkpoint inhibitors (ICI) fibroblast growth factor receptor (FGFR)-targeted therapeutics have had modest success bladder when used as monotherapy. Emerging data suggests the combination of these two therapies could lead improved clinical outcomes, but optimal strategy for combining agents remains uncertain. Mathematical models, specifically...
Globally, the incidence and mortality rates of gastric cancer are high, its poor prognosis is closely related to tumor recurrence metastasis. Therefore, molecular mechanisms associated with migration invasion cells important for treatment. Previously, TSPAN9 has been reported inhibit cell migration; however, underlying mechanism remains unclear.Human adenocarcinoma lines, SGC7901 AGS, were cultured in vitro. expression was determined by RT-PCR, western blot analysis, immunohistochemistry...
Abstract Background The issue of drug resistance in gastric cancer has attracted global attention. TSPAN9, a 4-transmembrane protein that plays an important role tumor progression and signal transduction, been found to be closely related invasion, metastasis, autophagy. Methods Immunoblotting was used evaluate TSPAN9 expression parental drug-resistant cells. Functional assays, such as the CCK-8 assay, were detect proliferation cells response 5-fluorouracil (5-FU). Western blotting analyze...
Abstract A growing body of evidence has revealed that microRNAs (miRNAs) play crucial roles in regulating osteoblasts and bone metabolism. However, the effects miRNAs osteoblast mechanotransduction remain to be defined. In this study, we investigated regulatory effect miR-33-5p tested its anti-osteopenia when delivered by an osteoblast-targeting delivery system vivo. First, demonstrated could promote activity mineralization without influencing their proliferation vitro. Then our data showed...
Fast and precise identification of microorganisms in the early diagnosis sepsis is crucial for enhancing patient outcomes. Digital PCR (dPCR) a highly sensitive approach absolute quantification that can be utilized as culture-independent molecular technique diagnosing pathogens. We performed retrospective investigation on 69 ICU patients suspected sepsis. Our findings showed multiplex dPCR diagnostic kit outperformed blood culture detecting 15 most frequent bacteria cause Ninety-two...
Abstract Immunotherapy has dramatically transformed the cancer treatment landscape largely due to efficacy of immune checkpoint inhibitors (ICIs). Although ICIs have shown promising results for many patients, low response rates in cancers highlight ongoing challenges treatment. Cytotoxic T lymphocytes (CTLs) execute their cell-killing function via two distinct mechanisms: a fast-acting, perforin-mediated process and slower, Fas ligand (FasL)-driven pathway. Evidence also suggests that...
Since the introduction of first immune checkpoint inhibitor (ICI), immunotherapy has changed landscape molecular therapeutics for cancers. However, ICIs do not work equally well on all cancers and patients. There been a growing interest in using mathematical computational models to optimize clinical responses. Ordinary differential equations (ODEs) have widely used mechanistic modeling immuno-oncology immunotherapy. They allow rapid simulations temporal changes cellular populations involved....
Abstract Background Polyamines play important roles in cell growth and proliferation. Polyamine metabolism genes are dysregulated various tumors. Some polyamine regulated by transcription factors. However, the factors that regulate have not been completely identified. Additionally, whether any of transcriptional regulations depend on tumor heterogeneity microenvironment has investigated. Methods We used bulk RNA‐seq data to identify their across breast cancer subtypes. Genes highly...
The flavonoid prescription baicalin-linarin-icariin-notoginsenoside R1 (BLIN) has a curative effect on duck virus hepatitis (DVH) caused by A type 1 (DHAV-1). However, the mechanism of this is not understood.This study investigates BLIN DVH DHAV-1. We analyzed anti-DHAV-1 reproduction and immuno-regulatory BLIN.The effects at 20, 10, 5 2.5 μg/mL in vitro, as well influence 20 DHAV-1 adsorption, replication release were tested using qRT-PCR method. promotion abilities T- B-lymphocyte...
Abstract Since the introduction of first immune checkpoint inhibitor (ICI), immunotherapy has changed landscape molecular therapeutics for cancers. However, ICIs do not work equally well on all cancers and patients. There been a growing interest in using mathematical computational models to optimize clinical responses. Ordinary differential equations (ODEs) have widely used mechanistic modeling immuno-oncology because they allow rapid simulations temporal changes cellular populations...
Graphical Abstract The proposed mechanism of injury-mediated Notch and vascular loop formation.
Coronary artery bypass grafting (CABG) surgery has been a widely accepted method for treating coronary disease. However, its postoperative complications can have significant effect on long-term patient outcomes. A retrospective study was conducted to identify before and after that contribute stroke in patients undergoing CABG, develop predictive models recommendations single-factor thresholds.
Abstract Within vascular networks, wall shear stress (WSS) modulates endothelial cell proliferation and arteriovenous specification. Mechano-responsive signaling pathways enable vessels within a connected network to structurally adapt properly partition blood flow between different parts of organ systems. Here, we study regeneration in zebrafish model system, performing tail amputation the Dorsal Aorta (DA)-Posterior Cardinal Vein (PCV) embryonic circulatory loop (ECL) at 3 days post...
Effects of external factors such as protein homeostasis can trigger the production endoplasmic reticulum stress, which be restored by unfolded response (UPR).The UPR plays a central role in development cancer biology, and it is also associated with various malignant characteristics, invasion metastasis.Malignant cells thrive under conditions, hypoxia, limits their ability to produce protein-folding, this impairs generate an anti-tumor immune response.Studies have revealed that effects ER...
Abstract Immunotherapy has dramatically transformed the cancer treatment landscape largely due to efficacy of immune checkpoint inhibitors (ICIs). Although ICIs have shown promising results for many patients, low response rates in cancers highlight ongoing challenges treatment. Cytotoxic T lymphocytes (CTLs) execute their cell-killing function via two distinct mechanisms: a fast-acting, perforin-mediated process and slower, Fas ligand (FasL)-driven path-way. Evidence also suggests that...
Abstract Objective: MicroRNAs (miRNAs) are crucial regulators of diverse biological and pathological process. This study aimed to investigate the role miR-20a in fluid shear stress(FSS)-mediated osteogenic differentiation. Methods: In present study, we subject osteoblast MC3T3-E1 cells or mouse bone marrow stromal cells(BMSCs) single bout short duration stress(12 dyn/cm 2 for 1 hour) by using a parallel plate flow system. The expression was quantified with miRNA array profiling quantitative...