A5001352462- Bone Metabolism and Diseases
- MicroRNA in disease regulation
- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- TGF-β signaling in diseases
- Bone health and treatments
- Circular RNAs in diseases
- Osteoarthritis Treatment and Mechanisms
- Dental Implant Techniques and Outcomes
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Endodontics and Root Canal Treatments
- dental development and anomalies
- Restraint-Related Deaths
- Foreign Language Teaching Methods
- Translation Studies and Practices
- Oral Health Pathology and Treatment
- Fibroblast Growth Factor Research
- Oral and gingival health research
- Oral microbiology and periodontitis research
- Global Health Workforce Issues
- Neurological Disease Mechanisms and Treatments
- Injury Epidemiology and Prevention
- Interpreting and Communication in Healthcare
- Dental Trauma and Treatments
Third Affiliated Hospital of Sun Yat-sen University
2009-2024
Sun Yat-sen University
2009-2024
Hunan University of Traditional Chinese Medicine
2023
National Natural Science Foundation of China
2013
Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
2013
Guangdong Province Stomatological Hospital
2013
Novem (Netherlands)
2013
Background Mechanical stress plays an important role in the maintenance of bone homeostasis. Current hypotheses suggest that interstitial fluid flow is component system by which tissue level strains are amplified bone. This study aimed to test hypothesis short-term and appropriate shear (FSS) expected promote terminal differentiation pre-osteoblasts detect expression profile microRNAs FSS-induced osteogenic MC3T3-E1 cells. Methods cells were subjected 1 hour FSS at 12 dyn/cm 2 using a...
Background: Fluid shear stress (FSS) is a major type of mechanical that loaded on human periodontal ligament cells (hPDLCs) during mastication and orthodontic tooth movement. This study aims to clarify the effect FSS osteogenic differentiation hPDLCs further verify involvement mitogen‐activated protein kinase (MAPK) signaling in this process. Methods: After isolation characterization, were subjected 2‐hour at 12 dynes/cm 2 , cell viability, gene mRNA expression, alkaline phosphatase (ALP)...
Fluid shear stress plays an important role in bone osteogenic differentiation. It is traditionally believed that pulsed and continuous load more favorable for fracture recovery homeostasis. However, according to our clinical practice, we notice one single also sufficient trigger In the present study, subject osteoblast MC3T3-E1 cells bout short duration fluid by using a parallel plate flow system. The results show 1 hour of at 12 dyn/cm2 promotes terminal differentiation, including...
MicroRNAs (miRNAs) are crucial regulators of diverse biological and pathological processes. This study aimed to investigate the role microRNA 20a (miR-20a) in fluid shear stress (FSS)-mediated osteogenic differentiation.In present study, we subjected osteoblast MC3T3-E1 cells or mouse bone marrow stromal (BMSCs) single bout short duration FSS (12 dyn/cm2 for 1 hour) using a parallel plate flow system. The expression miR-20a was quantified by miRNA array profiling real-time quantitative...
MicroRNAs (miRNAs) have been widely demonstrated to interact with multiple cellular signaling pathways and participate in a wide range of physiological processes. Estradiol-17 β (E2) is the most potent prevalent endogenous estrogen that plays vital role promoting bone formation reducing resorption. Currently, little known about regulation miRNAs E2-induced osteogenic differentiation. In present study, primary marrow mesenchymal stem cells from rats (rBMSCs) were isolated incubated E2,...
Background: Periodontitis (PD) is a chronic inflammatory disease caused by infection of the periodontal supporting tissues. Clinical studies have reported that rheumatoid arthritis (RA) patients higher prevalence PD. This study aimed to explore correlation between RA and Methods: A total 307 (RA group) 324 healthy individuals (control who received physical examinations during same period were recruited this study. The incidence PD in two groups was analyzed, index (PDI) bleeding on probing...
Introduction: This study aimed to determine whether miR-20 promoted osteogenic differentiation in bone marrow-derived mesenchymal stem/stromal cells (BMSCs) and accelerated formation the maxillary sinus defect model rabbits. Methods: BMSCs were transfected with miR-20a or anti-miR-20a for 12 h, followed by detection of RUNX2, Sp7 mRNA, morphogenetic protein 2 (BMP2), RUNX2 expression. Alkaline phosphatase (ALP) activity Alizarin Red S staining used detect calcified nodule deposition. In...
Ischemic stroke (IS) is a leading cause of mortality worldwide. Naotaifang III new Chinese herbal formula to treat IS. Previous studies have shown that Astragali Radix, Puerariae Lobatae Chuanxiong Rhizoma, and Rhei Radix Et Rhizoma in were able regulate the imbalance intestinal microbiota during cerebral ischemia injury.Rats randomly divided into sham operation group, normal control middle artery occlusion (MCAO) MCAO bacteria transplantation with 15 rats each group. Then, neurological...
The role of myosin light chain II (MLC‑II) in cellular differentiation rat mandibular condylar chondrocytes (MCCs) induced by cyclical uniaxial compressive stress (CUCS) remains unclear. In the current study, a four‑point bending system was used to apply CUCS primary cultured MCCs from rats. It identified that stimulated features including morphological alterations, cytoskeleton rearrangement and overproduction proteoglycans. Furthermore, promoted runt‑related transcription factor‑2 (RUNX2)...
In this study, we aimed to establish a rat tooth movement model assess miR-20's ability in enhancing the BMP2 signaling pathway and facilitate alveolar bone remodeling.
The aim of this study was to analyze the causes, clinical characteristics, social factors, and current status treatment traumatic dental injury (TDI) in primary dentition. A retrospective analysis performed on 144 children (213 teeth) with TDI dentition from our hospital between December 2017 June 2020. Data were analyzed using chi-square test Mann-Withney-Wilcoxon test. Boys accounted for 68.1% (98/144) girls 31.9% (46/144) all dentition, a boy-girl ratio 2.13:1. age deciduous teeth 2 4...
Objective To evaluate the efficiency of poly hydroxybutyrate-hydroxyvalerate (PHBV) membrane and PH BV - sol gel bioactive glass (PHBV SGBG) composite for promoting bone regeneration.methods Canine tibial defect models were established divided into four groups: PHBV +PHBV-SGBG group, PHBV-SGBG group control group. Specimens respectively collected from each at 2, 4, 8 12 weeks after operation growth assessment over region by scanning electron microscopy. Quantitative determination Ca P...
：Objective To study thecytocompatibility of poly (3-hydroxybutyrate-co-3 -hydroxyvalerate)/sol-gel bioactiveglass (PHBV/SGBG)composite with bone marrow stromal cells in vitro, and the vivoosteogenesis efficiency PHBV/SGBG composite under periosteal flap defect animalmodels. Methods The cytocompatibility was tested by MTT assay anddirect contact assay. Of established tibial canine models, wasembedded into defects experimental group, while no treatment given to thecontrol group. Samples were...
Abstract Objective: MicroRNAs (miRNAs) are crucial regulators of diverse biological and pathological process. This study aimed to investigate the role miR-20a in fluid shear stress(FSS)-mediated osteogenic differentiation. Methods: In present study, we subject osteoblast MC3T3-E1 cells or mouse bone marrow stromal cells(BMSCs) single bout short duration stress(12 dyn/cm 2 for 1 hour) by using a parallel plate flow system. The expression was quantified with miRNA array profiling quantitative...