A5103149035- Hormonal Regulation and Hypertension
- Extracellular vesicles in disease
- Congenital heart defects research
- SARS-CoV-2 and COVID-19 Research
- Pancreatic function and diabetes
- Electrical and Bioimpedance Tomography
- Heparin-Induced Thrombocytopenia and Thrombosis
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Electrochemical Analysis and Applications
- Renin-Angiotensin System Studies
- Adipose Tissue and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Blood properties and coagulation
- Biosensors and Analytical Detection
- Zebrafish Biomedical Research Applications
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Blood Pressure and Hypertension Studies
- COVID-19 Clinical Research Studies
- Axon Guidance and Neuronal Signaling
- Microfluidic and Bio-sensing Technologies
University of California, Los Angeles
2021-2023
VA Greater Los Angeles Healthcare System
2021-2023
University of Buenos Aires
2011
Consejo Nacional de Investigaciones Científicas y Técnicas
2010
The characterization of atherosclerotic plaques to predict their vulnerability rupture remains a diagnostic challenge. Despite existing imaging modalities, none have proven abilities identify metabolically active oxidized low-density lipoprotein (oxLDL), marker plaque vulnerability. To this end, we developed machine learning-directed electrochemical impedance spectroscopy (EIS) platform analyze oxLDL-rich plaques, with immunohistology serving as the ground truth. We fabricated EIS sensor by...
Activation of endothelial cells following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is thought to be the primary driver for increasingly recognized thrombotic complications in disease 2019 patients, potentially due SARS-CoV-2 Spike protein binding human angiotensin-converting enzyme (hACE2). Vaccination therapies use same sequence or boost host immune response as a protective mechanism against infection. As result, cases events are reported vaccination. Although...
Graphical Abstract The proposed mechanism of injury-mediated Notch and vascular loop formation.
Combining functional optical contrast with high spatiotemporal resolution, photoacoustic computed tomography (PACT) benefits mainstream cardiac imaging modalities for preclinical research. However, PACT has not revealed detailed vasculature or hemodynamics of the whole heart without surgical tissue penetration. Here, we present non-invasive rat hearts using recently developed three-dimensional (3D-PACT) platform. 3D-PACT utilizes optimized illumination and detection schemes to reduce effects...
Introduction: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), poses the worst global health crisis in modern times. Thrombotic complications such as VTE, pulmonary embolism, and risk of stroke affect more than 30% critically ill COVID-19 patients. Unfortunately, flow dynamics endothelial dysfunction underlying this outcome remains poorly understood. We hereby developed liposome-nanoparticles exposing functional S-Spike (Lipo-S) to simulate cell internalization route SARS-CoV-2....