A5001922046- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Prenatal Substance Exposure Effects
- Forensic Toxicology and Drug Analysis
- Receptor Mechanisms and Signaling
- Birth, Development, and Health
- Attention Deficit Hyperactivity Disorder
- Heavy Metal Exposure and Toxicity
- Cannabis and Cannabinoid Research
- Zebrafish Biomedical Research Applications
- Cholinesterase and Neurodegenerative Diseases
- Nicotinic Acetylcholine Receptors Study
- Pesticide Exposure and Toxicity
- Marine animal studies overview
- Anesthesia and Neurotoxicity Research
- Chemical synthesis and alkaloids
- Adipose Tissue and Metabolism
- Trace Elements in Health
- Neurogenesis and neuroplasticity mechanisms
- Effects and risks of endocrine disrupting chemicals
- Nerve injury and regeneration
- Insect and Pesticide Research
Cincinnati Children's Hospital Medical Center
2016-2025
University of Cincinnati
2015-2025
University of Cincinnati Medical Center
2015-2025
University of New Mexico
2023
Biogen (United Kingdom)
2020
Williams & Associates
2019
Neurology, Inc
2017
National Oceanic and Atmospheric Administration
2015
NOAA National Marine Fisheries Service
2012-2015
NOAA National Marine Fisheries Service Alaska Regional Office
2012-2015
Abstract d ‐Fenfluramine, a serotonin releaser, was administered to neonatal rats on postnatal days 11–20 (a stage of hippocampal development analogous third trimester human ontogeny). As adults, the ‐fenfluramine‐treated offspring exhibited dose‐related impairments sequential and spatial learning reference memory in absence sensorimotor impairments. Procedures minimize stress control for other performance effects prior testing demonstrated that nonspecific factors did not account selective...
Several disorders have been associated with mutations in Na,K-ATPase α isoforms (rapid-onset dystonia parkinsonism, familial hemiplegic migraine type-2), as well reduction content (depression and Alzheimer's disease), thereby raising the issue of whether haploinsufficiency or altered enzymatic function contribute to disease etiology. Three are expressed brain: α1 isoform is found many cell types, α2 predominantly astrocytes, α3 exclusively neurons. Here we show that mice heterozygous for...
Recent studies suggest that postmitotic neurons can reenter the cell cycle as a prelude to apoptosis after brain injury. However, most dying do not pass G 1 /S-phase checkpoint resume DNA synthesis. The specific factors trigger abortive synthesis are characterized. Here we show combination of hypoxia and ischemia induces adult rodent indicated by incorporation bromodeoxyuridine (BrdU) expression transition markers. After hypoxia-ischemia, majority BrdU- neuronal nuclei (NeuN)-immunoreactive...
Volatile anesthetics, such as isoflurane, are widely used in infants and neonates. Neurodegeneration neurocognitive impairment after exposure to midazolam, nitrous oxide neonatal rats have raised concerns regarding the safety of pediatric anesthesia. In mice, prolonged isoflurane triggers hypoglycemia, which could be responsible for impairment. We examined effects blood glucose on brain cell viability, spontaneous locomotor activity, well spatial learning memory mice.Seven-day-old mice were...
The importance of honey bees to the world economy far surpasses their contribution in terms production; they are responsible for up 30% world's food production through pollination crops. Since fall 2006, U.S. have faced a serious population decline, due part phenomenon called Colony Collapse Disorder (CCD), which is disease syndrome that likely caused by several factors. Data from an initial study investigators compared pathogens affected CCD suggested putative role Israeli Acute Paralysis...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAntineoplastic Agents, 120. Pancratium littoraleGeorge R. Pettit, Venkatswamy Gaddamidi, Delbert L. Herald, Sheo Bux Singh, Gordon M. Cragg, Jean Schmidt, Fred E. Boettner, Williams, and Yoneo SagawaCite this: J. Nat. Prod. 1986, 49, 6, 995–1002Publication Date (Print):November 1, 1986Publication History Published online1 July 2004Published inissue 1 November...
Gaucher disease is caused by defective acid β-glucosidase (GCase) function. Saposin C a lysosomal protein needed for optimal GCase activity. To test the in vivo effects of saposin on GCase, deficient mice (C−/−) were backcrossed to point mutated (V394L/V394L) mice. The resultant (4L;C*) began exhibit CNS abnormalities ∼30 days: first as hindlimb paresis, then progressive tremor and ataxia. Death occurred ∼48 days due neurological deficits. Axonal degeneration was evident brain stem, spinal...
Mutations in the creatine (Cr) transporter (CrT; Slc6a8) gene lead to absence of brain Cr and intellectual disabilities, loss speech, behavioral abnormalities. To date, no mouse model CrT deficiency exists which understand develop treatments for this condition. The purpose study was generate a human deficiency. We created mice with exons 2–4 Slc6a8 flanked by loxP sites crossed these Cre:CMV create line ubiquitous knockout expressing mice. Mice were tested learning memory deficits assayed...
For decades, regulatory guidelines for safety assessment in rodents drugs, chemicals, pesticides, and food additives with developmental neurotoxic potential have recommended a single test of learning memory (L&M). In recent years some agencies requested two such tests. Given the importance higher cognitive function to health, fact that different types L&M are mediated by brain regions assessing functions represents step forward providing better evidence-based protection against adverse...