A5018569553- Anesthesia and Pain Management
- Pain Mechanisms and Treatments
- Inflammasome and immune disorders
- Sirtuins and Resveratrol in Medicine
- Hormonal Regulation and Hypertension
- Ferroptosis and cancer prognosis
- Airway Management and Intubation Techniques
- Liver Disease and Transplantation
- Heme Oxygenase-1 and Carbon Monoxide
- Trace Elements in Health
- Intraoperative Neuromonitoring and Anesthetic Effects
- Spinal Hematomas and Complications
- Inflammatory mediators and NSAID effects
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Caveolin-1 and cellular processes
- Calcium signaling and nucleotide metabolism
- interferon and immune responses
- Botulinum Toxin and Related Neurological Disorders
- Sphingolipid Metabolism and Signaling
- Organ Transplantation Techniques and Outcomes
- Acute Kidney Injury Research
- Iron Metabolism and Disorders
- PARP inhibition in cancer therapy
Guangxi Medical University
2015-2024
First Affiliated Hospital of GuangXi Medical University
2015-2024
Hong Kong Shue Yan University
2013
Bupivacaine (BUP) may cause neurotoxic effects after spinal anesthesia. Resveratrol (RSV), a natural agonist of Silent information regulator 1 (SIRT1), protects various tissues and organs from damage by regulating endoplasmic reticulum (ER) stress. The aim this study is to explore whether RSV could alleviate the neurotoxicity induced bupivacaine via ER We established model bupivacaine-induced in rats using intrathecal injection 5% bupivacaine. protective effect was evaluated injecting...
Endoplasmic reticulum (ER) stress and apoptosis play significant roles in the development of neurotoxicity caused by bupivacaine (BUP). By activating sirtuin 1 (SIRT1), resveratrol (RSV) can regulate various cellular processes associated with anti‑oxidative stress, anti‑apoptosis anti‑inflammatory responses, thereby exerting neuroprotective effects. However, it remains unknown whether activation SIRT1 RSV is able to attenuate BUP‑induced ER apoptosis. Therefore, present study aimed explore...
Abstract Background Postoperative acute kidney injury (AKI) and chronic disease (CKD) following pediatric liver transplantation (PLT) have not been comprehensively studied. This study aimed to evaluate the correlation between AKI both 1‐year CKD mortality. Methods retrospective included 132 children aged 3 months 12 years who underwent PLT 2017 2021. after 1 year were assessed according KDIGO criteria. was classified as mild, moderate, or severe based on severity well transient (≤2 days)...
Objectives The molecular mechanism underlying the protective effects of DEX against sepsis-induced acute kidney injury (SAKI) remains to be elucidated.