A5054668602- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Signaling Pathways in Disease
- Cancer-related molecular mechanisms research
- Peroxisome Proliferator-Activated Receptors
- Sirtuins and Resveratrol in Medicine
- Lipid metabolism and disorders
- PARP inhibition in cancer therapy
- Ginseng Biological Effects and Applications
- Adipose Tissue and Metabolism
- Cell death mechanisms and regulation
- Atherosclerosis and Cardiovascular Diseases
- Metabolism, Diabetes, and Cancer
- Calcium signaling and nucleotide metabolism
- Bioactive natural compounds
- GDF15 and Related Biomarkers
- RNA modifications and cancer
Huazhong University of Science and Technology
2021-2024
Union Hospital
2021-2024
Union Hospital
2022-2024
Wuhan Union Hospital
2021
Abstract Macrophage inflammation plays a central role during the development and progression of sepsis, while regulation macrophages by parthanatos has been recently identified as novel strategy for anti‐inflammatory therapies. This study was designed to investigate therapeutic potential mechanism pimpinellin against LPS‐induced sepsis. PARP1 PAR activation were detected western blot or immunohistochemistry. Cell death assessed flow cytometry blot. metabolism measured with Seahorse XFe24...
The major clinical consequences of atherosclerosis such as myocardial infarction or stroke are because thrombotic events associated with acute rupture erosion an unstable plaque. Here, we identify lncRNA Noncoding Repressor NFAT (Nron) a critical regulator atherosclerotic plaque stability. Nron overexpression (OE) in vascular smooth muscle cells (VSMC) induces highly characteristic architecture more-vulnerable plaques, while knockdown (KD) suppresses the development and favors...
Deciphering the molecular and cellular processes involved in foam cell formation is critical for us to understand pathogenesis of atherosclerosis. Nuclear factor activated T cells (NFAT) a transcription originally identified as key player differentiation maturation immune system. Nowadays it has been brought into attention that NFAT also regulates multiple pathophysiological targeted intervention may be effective treatment some cardiovascular diseases. However, whether remains elusive. human...
Abstract Objective This study explores the role of ZHX2 in vascular remodeling, specifically focusing on its effects VSMC proliferation, migration, and neointima formation following injury. Methods Results: Data from both human atherosclerotic samples a mouse carotid injury model indicated decrease levels. In vivo , overexpression reduced mice subjected to artery ligation. vitro inhibited proliferation migration primary VSMCs. Conversely, specific knockout SMCs or knockdown VSMCs had...