A5047916703- RNA modifications and cancer
- Bone Tumor Diagnosis and Treatments
- Ferroptosis and cancer prognosis
- Soft tissue tumor case studies
- Oral and Maxillofacial Pathology
- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Esophageal Cancer Research and Treatment
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- High Altitude and Hypoxia
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Nanoplatforms for cancer theranostics
- Hippo pathway signaling and YAP/TAZ
- Fibroblast Growth Factor Research
- RNA Research and Splicing
- Peptidase Inhibition and Analysis
- AI in cancer detection
- Helicobacter pylori-related gastroenterology studies
- Wnt/β-catenin signaling in development and cancer
- Image Retrieval and Classification Techniques
- Medical Image Segmentation Techniques
- Histiocytic Disorders and Treatments
- Data Quality and Management
Air Force Medical University
2020-2024
State Council of the People's Republic of China
2022-2023
Xijing Hospital
2022
Nanchang University
2022
Tang Du Hospital
2022
Czech Academy of Sciences, Institute of Biotechnology
2022
Abstract Although haemoglobin is a known carrier of oxygen in erythrocytes that functions to transport over long range, its physiological roles outside are largely elusive 1,2 . Here we found chondrocytes produced massive amounts form eosin-positive bodies their cytoplasm. The body (Hedy) membraneless condensate characterized by phase separation. Production controlled hypoxia and dependent on KLF1 rather than the HIF1/2α pathway. Deletion leads Hedy loss along with severe hypoxia, enhanced...
Esophageal carcinoma (ESCA) is a common type of cancer with high mortality. Cuproptosis new cell death and characterized by the dependence on mitochondrial respiration protein lipoylation. However, potential roles cuproptosis-related genes (CRGs) in ESCA remain elusive. Here, we systematically assessed transcriptional genetic alterations CRGs ESCA. We identified signature for patients. A 6-CRGs was constructed least absolute shrinkage selection operator (LASSO) regression analysis along...
Heat stress is fundamental to esophageal carcinoma (ESCA) oncogenesis and progression. damages epithelial structure, causing aberrant 'cell death-repair' patterns of esophagus cells thereby driving tumor occurrence However, due the distinctive functions crosstalk regulatory cell death (RCD) patterns, specific deaths in ESCA malignancy are still unclear.We analyzed key genes involved heat progression by using The Cancer Genome Atlas-ESCA database. least absolute shrinkage selection operator...
Cuproptosis or copper-dependent cell death is a newly identified non-apoptotic pathway which plays critical role in the development of multiple cancers. Long non-coding RNAs (lncRNAs) are increasingly recognized as crucial regulators programmed and lung adenocarcinoma (LUAD) development, comprehensive understanding cuproptosis-related lncRNAs may improve prognosis prediction LUAD. However, few studies have explored association with LUAD.The RNA sequencing data corresponding clinical...
Abstract Immunotherapy is a promising cancer therapeutic strategy. However, the “cold” tumor immune microenvironment (TIME), characterized by insufficient cell infiltration and immunosuppressive status, limits efficacy of immunotherapy. Tumor vascular abnormalities due to defective pericyte coverage are gradually recognized as profound determinant in TIME establishment hindering trafficking. Recently, several normalization strategies improving have been reported, whereas unsatisfactory high...
Tumor Immunotherapy vascular abnormalities is a profound determinant in the "cold" tumor immune microenvironment establishment by hindering immunotherapy efficacy. PDGFB@ZIF8-RGD effectively induced normalization, reprogramming TIME to "hot" and facilitated robust antitumor immunity. More article number 2308638, Yongquan Qu, Jie Lei, Junlong Zhao, Tao Jiang, co-workers.
Alternative splicing (AS) is a critical mechanism of post-transcriptional regulation and has been widely reported to be associated with the tumor progression microenvironment (TME) formation. However, role AS in lung adenocarcinoma (LUAD) not clearly elucidated. This study presents comprehensive analysis exploring impact on prognosis TME LUAD.The gene expression transcriptome profiles survival data were obtained from The Cancer Genome Atlas (TCGA) database, TCGA SpliceSeq database. Base...
3D medical image segmentation is a challenging task with crucial implications for disease diagnosis and treatment planning. Recent advances in deep learning have significantly enhanced fully supervised segmentation. However, this approach heavily relies on labor-intensive time-consuming annotated ground-truth labels, particularly volumes. To overcome limitation, we propose novel probabilistic-aware weakly pipeline, specifically designed imaging. Our pipeline integrates three innovative...
ABSTRACT Bizarre parosteal osteochondromatous proliferation (BPOP), or Nora's lesion, is a rare benign lesion. At present, the molecular etiology of BPOP remains unclear. JMJD3(KDM6B) an H3K27me3 demethylase and counteracts polycomb-mediated transcription repression. Previously, Jmjd3 was shown to be critical for bone development osteoarthritis. Here, we report that conditional deletion in chondrogenic cells unexpectedly resulted BPOP-like lesion mice. Biochemical investigations revealed...
Background: The non-negligible role of epigenetic modifications in cancer development and tumor microenvironment (TME) has been demonstrated recent studies. Nonetheless, the potential regulatory N7-methylguanosine (m7G) modification shaping impacting TME remains unclear. Methods: A comprehensive analysis was performed to explore m7G patterns based on 24 regulators 817 lung adenocarcinoma (LUAD) patients, landscape distinct were evaluated. score established principal component (PCA) quantify...
At present more than 9 million people die of cancer every year. Simple and broad-spectrum drugs are still an urgent need for patients. Recently, we proposed a new hypothesis that intracellular osmotic pressure (IOP) is the driving force cell division, abnormal tumor proliferation result uncontrolled IOP in cells. On one hand, aneuploidy function Na+/K+ pump lead to faster rise normal cells, on other abnormality cytoskeleton assembly leads decrease tolerance limit membrane (TLCM) cells...
Background: Metachondromatosis (MC) is a rare hereditary disease with multiple osteochondromatous exostoses at the hands or feet. PTPN11/SHP2 inactivating mutations were essential for development of MC.However, epigenetic target MC remains unknown.Methods: Microcomputed tomography, chondrocyte differentiation assay, RNA-Seq and Chip-Seq analysis applied to achieve better understanding in development.Findings: Here, we unexpectedly detected that heterozygous homozygous Ezh2 inactivation...
Background: The invasive potential is regarded as a pivotal determinant in the prognosis of lung adenocarcinoma (LUAD). However, cell ecology and spatial niche implicated dynamic sequential process LUAD from situ (AIS) to microinvasive carcinoma (MIA) subsequent (IAC) are not elucidated yet.Methods: Droplet-based single-cell RNA sequencing (scRNA-seq) was performed map cellular cancer cells tumour microenvironment (TME) three stages LUAD, paired tissues were simultaneously examined by...
Abstract Esophageal carcinoma (ESCA) is a common type of cancer with high mortality. Cuproptosis new cell death and characterized by the dependence on mitochondrial respiration protein lipoylation. However, potential roles cuproptosis-related genes (CRGs) in ESCA remains elusive. Here, we systematically assessed transcriptional genetic alterations ESCA. We identified signature for patients. A 6-CRGs was constructed Least absolute shrinkage selection operator (LASSO) regression analysis along...
Body axial patterning develops via a rostral-to-caudal sequence and relies on the temporal colinear activation of Hox genes. However, underlying mechanism gene remains largely elusive. Here, with small-molecule inhibitors conditional knockout mice, we identified Jmjd3, subunit TrxG, as an essential regulator genes its H3K27me3 demethylase activity. We demonstrated that Jmjd3 not only initiates but also maintains collinear expression detected no antagonistic roles between Ezh2, core PcG...