A5078146785- Alzheimer's disease research and treatments
- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Cholinesterase and Neurodegenerative Diseases
- Photoreceptor and optogenetics research
- Neurological disorders and treatments
- Synthesis and Characterization of Pyrroles
- Moyamoya disease diagnosis and treatment
- Blind Source Separation Techniques
- Retinal Imaging and Analysis
- Neural dynamics and brain function
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neural Engineering
- Multicomponent Synthesis of Heterocycles
- Synthesis and biological activity
- Energy Load and Power Forecasting
- 14-3-3 protein interactions
- Pituitary Gland Disorders and Treatments
- Prion Diseases and Protein Misfolding
- Artificial Intelligence in Healthcare
- Gastric Cancer Management and Outcomes
- Vehicle License Plate Recognition
- Nicotinic Acetylcholine Receptors Study
- Genetics and Neurodevelopmental Disorders
Yangon Technological University
2019-2024
Iraqi University
2024
Saveetha University
2024
Royal Adelaide Hospital
2012
University of California, San Francisco
2005-2010
Gladstone Institutes
2006-2010
Striatal GABAergic microcircuits are critical for motor function, yet their properties remain enigmatic due to difficulties in targeting striatal interneurons electrophysiological analysis. Here, we use Lhx6-GFP transgenic mice identify and investigate regulation of direct- indirect-pathway medium spiny neurons (MSNs). We find that the two major interneuron populations, persistent low-threshold spiking (PLTS) fast (FS) interneurons, differ substantially excitatory inputs inhibitory outputs....
Long-term memory relies on modulation of synaptic connections in response to experience. This plasticity involves trafficking AMPA receptors (AMPAR) and alteration spine morphology. Arc, a gene induced by activity, mediates the endocytosis is required for both long-term homeostatic plasticity. We found that Arc increases density regulates morphology increasing proportion thin spines. Furthermore, specifically reduces surface GluR1 internalization at spines, mutants fail facilitate AMPAR do...
Reelin regulates nervous system development and modulates synaptic plasticity in the adult brain. Several findings suggest that alterations signaling may contribute to neuronal dysfunction associated with Alzheimer's disease (AD). Cell surface receptors for Reelin, including integrins very-low-density lipoprotein receptor/apolipoprotein E2 receptor, be targets of amyloid-β (Aβ) peptides presumed play key roles pathogenesis AD. also extent tau phosphorylation. Finally, increased amounts...
Most gamma-aminobutyric acidergic interneurons in the neocortex and hippocampus are derived from subpallial progenitors medial ganglionic eminence migrate tangentially to pallium, where they differentiate into a diverse set of neuronal subtypes. Toward elucidating mechanisms underlying generation interneuron diversity, we have studied mice expression patterns differentiating mature neocortical 8 transcription factors, including 6 homeobox (Dlx1, Dlx2, Dlx5, Arx, Lhx6, Cux2), 1 basic...
Previous studies suggested that cleavage of the amyloid precursor protein (APP) at aspartate residue 664 by caspases may play a key role in pathogenesis Alzheimer's disease. Mutation this site (D664A) prevents caspase and generation C-terminal APP fragments C31 Jcasp, which have been proposed to mediate amyloid-beta (Abeta) neurotoxicity. Here we compared human transgenic mice with (B254) without (J20) D664A mutation battery tests. Before Abeta deposition, hAPP-B254 hAPP-J20 had comparable...
An effective process for the green and rapid synthesis of biologically active polysubstituted pyrroles 1,2,4,5-tetrasubstituted imidazoles derivatives using Cu@imine/Fe3O4 MNPs catalyst under solvent-free conditions is explained. This showed high reactivity a set different imidazole appropriate reaction short times. Moreover, was also recycled reused six runs with no considerable reduction in yields. Compared to reported procedures, this method consistently demonstrates advantages low...
Electric load forecasting is a vital task for energy management and policy-making. However, it also challenging problem due to the complex dynamic nature of electric data. In this paper, novel technique, called LSV/MOPA, has been proposed forecasting. The technique hybrid model that combines advantages Long Short-Term Memory (LSTM) Support Vector Regression (SVR), two powerful artificial intelligence algorithms. further optimized by newly Modified Orca Predation Algorithm (MOPA), which...
This paper presents an innovative framework for the automated diagnosis of gastric cancer using artificial intelligence. The proposed approach utilizes a customized deep learning model called MobileNetV2, which is optimized Dynamic variant Pelican Optimization Algorithm (DPOA). By combining these advanced techniques, it feasible to achieve highly accurate results when applied dataset endoscopic images. To evaluate performance based on benchmark, its data divided into training (80 %) and...
Aberrant excitatory neuronal activity and compensatory inhibitory mechanisms may play an important role in Alzheimer's disease (AD). Human amyloid precursor protein (hAPP) transgenic mice with high levels of amyloid-β peptides the brain develop AD-like abnormalities, including cognitive deficits depletions synaptic activity-related proteins dentate gyrus, a region critically involved learning memory. We previously demonstrated that hAPP have spontaneous non-convulsive seizure cortical...
Previous studies have suggested that cleavage of APP at aspartate residue 664 by caspase(s) may play a role in the pathogenesis AD. Mutation this site (D664A) prevents caspase and generation C-terminal fragment C31. Recently, D664A-mutant hAPP transgenic mice were reported to lack behavioral, electrophysiological, biochemical abnormalities typically seen lacking mutation. Objective: To compare side-by-side line J20 [Nat Neurosci 11: 1311] with B254 [PNAS 103: 7130] number pertinent assays....
Why distinct neurodegenerative disorders affect specific neuronal populations is largely unknown. Granule cells of the dentate gyrus are particularly vulnerable to Aβ-induced molecular and functional impairments. Aβ may exert these effects within granule cells, in their immediate extracellular milieu after being released from or synaptic contacts, by affecting neurons distant regions that provide afferent input cells. To identify where first acts entorhinal-hippocampal network ultimately...
Cognitive deficits in human amyloid precursor protein (hAPP) transgenic mice are tightly linked to the depletion of calcium–dependent proteins granule cells dentate gyrus, and similar molecular alterations have been found cases with Alzheimer's disease (AD) [PNAS 100: 9572; J. Neurosci. 25: 9686]. Several lines evidence suggest that these may involve an attenuation NMDA–dependent signaling pathways regulate synaptic activity–dependent genes, such as Arc Fos. Calcium–dependent also decreased...
Reelin plays key roles in nervous system development and also modulates synaptic plasticity the adult brain. Several lines of evidence suggest that alterations signaling may contribute to neuronal dysfunction associated with Alzheimer's disease (AD). extent tau phosphorylation. Cell surface receptors for Reelin, including integrins VLDLR/ApoE2R, be targets amyloid–β (Aβ), peptide widely believed cause AD. Signaling molecules linked e.g. Fyn kinase, modulate severity AD–related deficits...