A5100630224- Acute Myeloid Leukemia Research
- Acute Lymphoblastic Leukemia research
- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Hematological disorders and diagnostics
- Retinoids in leukemia and cellular processes
- Viral-associated cancers and disorders
- Eosinophilic Disorders and Syndromes
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- Traditional Chinese Medicine Analysis
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Apelin-related biomedical research
- Effects and risks of endocrine disrupting chemicals
- CAR-T cell therapy research
- RNA modifications and cancer
- Eosinophilic Esophagitis
- Nail Diseases and Treatments
- Methemoglobinemia and Tumor Lysis Syndrome
- Insects and Parasite Interactions
- Cytomegalovirus and herpesvirus research
- Clinical Laboratory Practices and Quality Control
Fred Hutch Cancer Center
2015-2025
University of Washington
2016-2025
ShenZhen People’s Hospital
2019-2025
Third Affiliated Hospital of Sun Yat-sen University
2021-2023
Sun Yat-sen University
2021-2023
Liuzhou General Hospital
2023
University of Washington Medical Center
2014-2022
Seattle Cancer Care Alliance
2014-2021
Southwest University
2021
Second Affiliated Hospital of Zhejiang University
2020
Purpose Both presence of minimal residual disease (MRD) and achievement complete remission (CR) with incomplete platelet recovery (CRp) rather than CR after induction therapy predict relapse in acute myeloid leukemia (AML). These results suggest a correlation between response (peripheral count recovery) MRD at the time morphologic remission. Here we examine this hypothesis whether provide independent prognostic information accounting for other relevant covariates. Patients Methods We...
Eosinophilia is rare in pediatric acute lymphoblastic leukemia. In this report, we present a case of leukemia with marked eosinophilia, whose diagnosis was delayed because clonorchiasis.
The fifth edition of the WHO classification haematolymphoid tumours (WHO-HEM5) introduces significant advancements in understanding and diagnosis myeloid neoplasms, emphasising molecular genetic insights. This review highlights key updates from revised fourth (WHO-HEM4R), particularly integration criteria for disease classification. Many entities are now defined by specific abnormalities, enhancing diagnostic precision prognostic assessment. Notably, elimination 20% blast threshold acute...
To review clinical data, cytogenetic findings, and flow cytometric analysis in 20 patients with T-cell prolymphocytic leukemia (T-PLL), a rare, aggressive, mature poor prognosis short survival.Using multiparameter cytometry large combination of antibodies, we summarize the immunophenotypic features T-PLL, including unusual variants, illustrate clues that may help distinguish this entity from other malignancies.By cytometry, T-PLL is characterized by postthymic immunophenotype variety...
Many studies have shown that natural dietary agents, in combination with chemical can improve the therapeutic response of cancers to chemotherapy and reduce associated side-effects. In present study, we investigated potential mechanisms anticancer effects for 5-fluorouracil (5-FU) resveratrol (Res). these studies, employed cancer cell lines TE-1 A431 an animal model skin cancer. The presented results provide first evidence Res enhance anti-tumor potency 5-FU by inducing S-phase arrest....
Secondary acute myeloid leukemia (sAML) is biologically and clinically distinct from de novo AML shares specific genetic mutations with myelodysplastic syndromes (MDS). We retrospectively analyzed data 295 adults MDS or mutational analysis by next-generation sequencing (NGS), examined differences in functional grouping of relation between morphologic blast count variant allele frequency (VAF) mutations. Our showed the distribution differed AML. However, these largely disappeared when we...
The presence of measurable residual disease after therapy is a significant risk factor relapse in patients with acute myeloid leukemia (AML). By detecting cells leukemia-associated immunophenotype (LAIP), multiparameter flow cytometry (MFC) can detect at level significantly lower than that detected by morphology. However, changes LAIPs during or may pose challenge to MRD testing. AML mutated NPM1 represents the largest subtype sharing common leukemogenic mechanism and similar LAIPs. Here, we...
Purpose The promise of precision oncology is that identification genomic alterations will direct the rational use molecularly targeted therapy. This approach particularly applicable to neoplasms are resistant standard cytotoxic chemotherapy, like T-cell leukemias and lymphomas. In this study, we tested feasibility next-generation sequencing in profiles diverse focused on therapeutic utility targeting activated JAK1 JAK3 an index case. Patients Methods Using Foundation One Heme assays,...
Detection of minimal residual disease (MRD) by flow cytometry (FCM) in B lymphoblastic leukemia (B ALL) is important for guiding patient-specific clinical management. We describe apparent expression CD19 natural killer cells as a potential confounder the detection ALL MRD FCM. This finding was noted seven different patient samples analyzed on days part routine care our laboratory, with analysis anti-CD19 antibody clones and fluorochrome conjugates five samples. Although etiology this not...
Abstract This study reports the pharmacologic effects of isatuximab, a CD38 mAb, on T- and B-cell acute lymphoblastic leukemia (ALL). We analyzed expression in 50-T-ALL 50 B-ALL clinical samples, 16 T-ALL 11 cell lines. primarily focused vitro assessments isatuximab-mediated antibody-dependent cellular cytotoxicity (ADCC) phagocytosis (ADCP). In vivo assessment isatuximab activity was performed several ALL xenograft models, including disseminated subcutaneous tumor models female C.B-17...
A 14-year-old boy presented with chronic myelogenous leukemia (CML) in blast phase segregated extramedullary (nodal) myeloid sarcoma and T-lymphoblastic lymphoma. Immunohistochemical stains performed on the lymphadenectomy sample demonstrated T lymphoblasts lymph nodes myeloblasts adjacent soft tissue. Fluorescence situ hybridization paraffin sections confirmed that both T-lymphoblast myeloblast populations were positive for t(9;22) BCR/ABL1 translocation. Subsequent flow cytometry analysis...
Abnormalities involving chromosome 7 are one of the most frequent chromosomal aberrations in myeloid neoplasms including myelodysplastic syndromes (MDS) and acute leukemia (AML) associated with an adverse prognosis. Immunophenotyping by flow cytometry provides data that can assist diagnosis classification neoplasms. The immunophenotypic features monosomy or del(7q) have not been previously described a comprehensive fashion.We retrospectively analyzed cytometric summarized features.Myeloid...
In solid tumors, decreased absolute lymphocyte count (ALC) at diagnosis was found to be associated with poorer outcome, but there is only limited data on the impact of ALC in acute myeloid leukemia (AML). this study we evaluated prognostic value outcome 259 adult patients AML who responded induction therapy. Higher than normal shorter remission (HR 4.06; p < 0.001), and relapse free overall survival 3.47; 0.001 HR 3.85; respectively). Flow cytometry showed low frequency natural killer (NK)...