A5040168987- Genomics, phytochemicals, and oxidative stress
- Cytokine Signaling Pathways and Interactions
- Mangiferin and Mango Extracts
- Phytochemicals and Antioxidant Activities
- Bioactive Compounds and Antitumor Agents
- Natural product bioactivities and synthesis
- Cancer Mechanisms and Therapy
- Medicinal Plant Pharmacodynamics Research
- MicroRNA in disease regulation
- Natural Antidiabetic Agents Studies
- Medicinal Plants and Bioactive Compounds
- Ginger and Zingiberaceae research
- Natural Compounds in Disease Treatment
- Cancer Cells and Metastasis
- Cancer-related molecular mechanisms research
- Natural Compound Pharmacology Studies
- Free Radicals and Antioxidants
- Phytochemistry and Bioactive Compounds
- Protein Tyrosine Phosphatases
- Flavonoids in Medical Research
- COVID-19 Clinical Research Studies
- Antioxidants, Aging, Portulaca oleracea
- Saffron Plant Research Studies
- Antioxidant Activity and Oxidative Stress
- Cell death mechanisms and regulation
King Faisal University
2019-2025
Saveetha University
2022-2024
Tunghai University
2019
Central University of Tamil Nadu
2019
Molecular Oncology (United States)
2019
University of California, Los Angeles
2019
The University of Texas Southwestern Medical Center
2019
China Medical University
2017-2018
National University of Singapore
2010-2016
Sri Ramachandra Institute of Higher Education and Research
2016
Polycyclic aromatic hydrocarbons (PAHs) are a group of compounds consisting two or more fused rings. Most them formed during incomplete combustion organic materials such as wood and fossil fuels, petroleum products, coal. The composition PAH mixtures varies with the source is also affected by selective weathering effects in environment. PAHs ubiquitous pollutants frequently found variety environments fresh water marine sediments, atmosphere, ice. Due to their widespread distribution,...
BACKGROUND AND PURPOSE Constitutive activation of the signal transducer and activator transcription 3 (STAT3) pathway is frequently encountered in several human cancers including multiple myeloma (MM). Thus, agents that suppress STAT3 phosphorylation have a potential for treatment MM. In present report, we investigated whether thymoquinone (TQ), main component isolated from medicinal plant Nigella sativa , modulated signalling MM cells. EXPERIMENTAL APPROACH The effect TQ on both...
Constitutive activation of signal transducer and activator transcription 3 (STAT3) has been linked with proliferation, survival, invasion angiogenesis a variety human cancer cells, including hepatocellular carcinoma (HCC). Thus, novel agents that can suppress STAT3 have potential for both prevention treatment HCC. Here we report, garcinol, polyisoprenylated benzophenone, could in HCC cell lines xenografted tumor nude mice model.Different treated garcinol the inhibition activation,...
Abstract Cumulative evidences(s) have established that the constitutive activation of STAT3 plays a pivotal role in proliferation, survival, metastasis, and angiogenesis thus can contribute directly to pathogenesis hepatocellular carcinoma (HCC). Thus, novel agents inhibit potential for both prevention treatment HCCs. The effect celastrol on activation, associated protein kinases, STAT3-regulated gene products, cellular apoptosis was investigated. vivo growth human HCC xenograft tumors...
The activation of signal transducers and activators transcription 3 (STAT3) has been closely linked with the proliferation, survival, invasion, angiogenesis hepatocellular carcinoma (HCC) represents an attractive target for therapy. In present report, we investigated whether honokiol mediates its effect through interference STAT3 pathway. on activation, associated protein kinases, phosphatase, STAT3-regulated gene products apoptosis was using both functional proteomics tumor pathway...
The activation of signal transducer and activator transcription 3 (STAT3) has been linked with the proliferation, survival, invasion, angiogenesis a variety human cancer cells, including hepatocellular carcinoma (HCC). Agents that can suppress STAT3 have potential for prevention treatment HCC. In this study, we tested an agent, β-escin, its ability to activation. We found pentacyclic triterpenoid, inhibited both constitutive interleukin-6-inducible in dose- time-dependent manner HCC cells....
Abstract Purpose: Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide and third cause of global cancer mortality. Increasing evidence suggest that STAT3 a critical mediator oncogenic signaling in HCC controls expression several genes involved proliferation, survival, metastasis, angiogenesis. Thus, novel agents can suppress activation have potential for both prevention treatment HCC. Experimental Design: The effect butein on activation, associated protein kinases,...
BACKGROUND AND PURPOSE Activation of signal transducer and activator transcription 3 (STAT3) play a critical role in the survival, proliferation, angiogenesis chemoresistance tumour cells. Thus, agents that suppress STAT3 phosphorylation have potential as cancer therapies. In present study, we investigated whether apoptotic, antiproliferative chemosensitizing effects γ‐tocotrienol are associated with its ability to activation hepatocellular carcinoma (HCC). EXPERIMENTAL APPROACH The effect...
Activation of pro-inflammatory transcription factors NF-κB and signal transducer activator 3 (STAT3) is one the major contributors to both pathogenesis chemoresistance in multiple myeloma (MM), which results high mortality rate. Thus, present study, we investigated whether celastrol could suppress proliferation induce chemosensitization MM cells by interfering with STAT3 activation pathways.The effects were using a virtual predictive tumour cell system different lines resistant doxorubicin,...
Abstract Background Increasing evidence indicates that the interaction between CXC chemokine receptor-4 (CXCR4) and its ligand CXCL12 is critical in process of metastasis accounts for more than 90% cancer-related deaths. Thus, novel agents can downregulate CXCR4/CXCL12 axis have therapeutic potential inhibiting cancer metastasis. Methods In this report, we investigated an agent, plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone), ability to modulate CXCR4 expression function various tumor...
In this study, kaempferol (KFL) shows hepatoprotective activity against zearalenone (ZEA)-induced oxidative stress and its underlying mechanisms in vitro vivo models were investigated. Oxidative plays a critical role the pathophysiology of various hepatic ailments is normally regulated by reactive oxygen species (ROS). ZEA mycotoxin known to exert toxicity via inflammation ROS accumulation. This study aims explore protective KFL ZEA-triggered injury PI3K/Akt-regulated Nrf2 pathway. augmented...