A5021003825- Natural product bioactivities and synthesis
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Phytochemicals and Medicinal Plants
- NF-κB Signaling Pathways
- Essential Oils and Antimicrobial Activity
- Bioactive Compounds and Antitumor Agents
- Medicinal plant effects and applications
- Curcumin's Biomedical Applications
- Cancer Mechanisms and Therapy
- Cell death mechanisms and regulation
- Chemokine receptors and signaling
- Phytochemistry and biological activity of medicinal plants
- Nanoparticle-Based Drug Delivery
- Natural Compounds in Disease Treatment
- Cancer therapeutics and mechanisms
- Cancer, Hypoxia, and Metabolism
- RNA Interference and Gene Delivery
- Toxin Mechanisms and Immunotoxins
- Phytochemical and Pharmacological Studies
- Cytokine Signaling Pathways and Interactions
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Synthesis and pharmacology of benzodiazepine derivatives
- Gastric Cancer Management and Outcomes
Amala Institute of Medical Sciences
2007-2025
Duke-NUS Medical School
2012-2020
National University of Singapore
2010-2018
The University of Western Australia
2012
Genome Institute of Singapore
2012
Because of poor prognosis and development resistance against chemotherapeutic drugs, the existing treatment modalities for gastric cancer are ineffective. Hence, novel agents that safe effective urgently needed. Whether γ-tocotrienol can sensitize to capecitabine in vitro a xenograft mouse model was investigated.The effect on proliferation cell lines examined by mitochondrial dye uptake assay, apoptosis esterase staining, NF-κB activation DNA-binding gene expression Western blotting. The...
Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis accounts for more than 90% prostate cancer related deaths patients. Thus, novel drugs can downregulate axis have great potential treatment metastatic cancer. In this report, we tested an agent, ursolic acid (UA) its ability to modulate CXCR4 expression cell lines and inhibit vivo transgenic adenocarcinoma mouse (TRAMP) model. We observed UA downregulated cells...
BACKGROUND AND PURPOSE Activation of signal transducer and activator transcription 3 (STAT3) play a critical role in the survival, proliferation, angiogenesis chemoresistance tumour cells. Thus, agents that suppress STAT3 phosphorylation have potential as cancer therapies. In present study, we investigated whether apoptotic, antiproliferative chemosensitizing effects γ‐tocotrienol are associated with its ability to activation hepatocellular carcinoma (HCC). EXPERIMENTAL APPROACH The effect...
Abstract Background Increasing evidence indicates that the interaction between CXC chemokine receptor-4 (CXCR4) and its ligand CXCL12 is critical in process of metastasis accounts for more than 90% cancer-related deaths. Thus, novel agents can downregulate CXCR4/CXCL12 axis have therapeutic potential inhibiting cancer metastasis. Methods In this report, we investigated an agent, plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone), ability to modulate CXCR4 expression function various tumor...
Accumulating evidence(s) indicate that CXCL12-CXCR4 signaling cascade plays an important role in the process of invasion and metastasis accounts for more than 80% deaths hepatocellular carcinoma (HCC) patients. Thus, identification novel agents can downregulate CXCR4 expression its associated functions have a great potential treatment metastatic HCC. In present report, we investigated anthraquinone derivative, emodin ability to affect as well function HCC cells. We observed downregulated...
Several lines of evidence have demonstrated that deregulated activation NF-κB plays a pivotal role in the initiation and progression variety cancers including multiple myeloma (MM). Therefore, novel molecules can effectively suppress upregulation potentially reduce MM growth. In this study, effect celastrol (CSL) on patient derived CD138+ cell proliferation, apoptosis, invasion, migration was investigated. addition, we studied whether CSL potentiate apoptotic bortezomib, proteasome inhibitor...
The effect of Punarnavine on the immune system was studied using Balb/c mice. Intraperitoneal administration (40 mg/kg body weight) found to enhance total WBC count 6th day. Bone marrow cellularity and number α-esterase positive cells were also increased by Punarnavine. Treatment along with antigen, sheep red blood (SRBC), produced an enhancement in circulating antibody titer plaque forming (PFC) spleen. Maximum PFC obtained showed enhanced proliferation splenocytes, thymocytes bone both...
Angiogenesis, the formation of new capillaries from preexisting vessels, is essential for tumor progression. Ursolic acid inhibited tumor-associated capillary in C57BL/6 mice induced by highly metastatic B16F-10 melanoma cells. The levels serum vascular endothelial growth factor (VEGF), NO, and proinflammatory cytokines were significantly reduced ursolic acid—treated animals compared with those control animals. diminished expressions VEGF iNOS genes cells treated nontoxic concentrations...
Pancreatic cancer remains one of the most difficult to treat human cancers despite recent advances in targeted therapy. Inhibition isoprenylcysteine carboxylmethyltransferase (ICMT), an enzyme that posttranslationally modifies a group proteins including several small GTPases, suppresses proliferation some cells. However, efficacy ICMT inhibition on pancreatic has not been evaluated. In this study, we have evaluated panel cell lines and identified those are sensitive inhibition. these cells,...
Abstract STAT3 is a key oncogenic transcription factor, often overactivated in several human cancers including hepatocellular carcinoma (HCC). modulates the expression of genes that are connected with cell proliferation, antiapoptosis, metastasis, angiogenesis, and immune evasion tumor cells. In this study, we investigated effect crocetin on growth HCC cells dissected its underlying molecular mechanism imparting cytotoxic effect. Crocetin suppressed promoted apoptosis, counteracted invasive...
Abstract Background Dibenzoazepine (DB) derivatives are important and valuable compounds in medicinal chemistry. The synthesis chemotherapeutic properties of naturally occurring DBs different heterocyclic moiety tethered reported. Herein, we report the DB-fused hybrid structure that containing isoxazolines (DBIs) their anti-cancer activity, which could throw light on structural functional features new molecules. Results Conclusion characterization novel ring DB isoxazoline were carried out....
Despite advances in modern medicine, cancer is still the major cause of mortality both developing and developed countries. Search for safer more effective chemoprevention treatment strategy a need improvement patient care field. Prevention may be less costly because largely preventable disease which could attributed to greater extent lifestyle. Dietary phytochemicals have been used throughout history due their safety, low toxicity, general availability. Population based studies suggest that...
Effect of Punarnavine on the cell-mediated immune (CMI) response in metastatic condition was studied using C57BL/6 mice model. Administration enhanced Natural Killer (NK) cell activity, antibody-dependent cellular cytotoxicity (ADCC) and complement mediated (ACC) activity observed treated group much earlier compared to tumor-bearing control. Production cytokines such as IL-2 IFN-gamma were significantly by administration untreated Peaks pro-inflammatory IL-1beta, IL-6 TNF-alpha lowered The...
The radioprotective effect of the hydro-alcoholic extract Boerhaavia diffusa was studied using in vivo mice model. sublethally irradiated (600 rads, single dose) were treated intraperitoneally with 20 mg/kg extract. animals sacrificed at different time periods after whole-body radiation. most affected tissues--bone marrow and intestine--were considerably protected by intraperitoneal administration B. as estimated bone cellularity, maturing monocytes, intestinal glutathione. Total white blood...
Abstract Cancer stem cells possess the capacity for self-renewal and resistance to chemotherapy. It is therefore crucial understand molecular regulators of stemness in quest develop effective cancer therapies. TAZ a transcription activator that promotes cell functions post-development mammalian cells; suppression activity reduces or eliminates select cancers. Isoprenylcysteine carboxylmethyltransferase (ICMT) unique enzyme last step posttranslational prenylation processing pathway modifies...