A5002652395- Fluoride Effects and Removal
- Nanoparticles: synthesis and applications
- Heavy Metal Exposure and Toxicity
- Vitamin C and Antioxidants Research
- Cancer Mechanisms and Therapy
- Genomics, phytochemicals, and oxidative stress
- FOXO transcription factor regulation
- Cytokine Signaling Pathways and Interactions
- Mercury impact and mitigation studies
- Glutathione Transferases and Polymorphisms
- Bone and Dental Protein Studies
- Folate and B Vitamins Research
- Heat shock proteins research
- Cell death mechanisms and regulation
- Anesthesia and Neurotoxicity Research
- Phytochemistry and Biological Activities
- Advanced Nanomaterials in Catalysis
- Phytochemistry and biological activity of medicinal plants
- Flavonoids in Medical Research
- Zebrafish Biomedical Research Applications
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Computational Drug Discovery Methods
- PI3K/AKT/mTOR signaling in cancer
- Ferroptosis and cancer prognosis
Bharathiar University
2016-2025
Defence Research and Development Organisation
2018-2023
Karger Publishers (Switzerland)
2015
University of Madras
2005-2011
Aberrant activation of STAT3 is frequently encountered and promotes proliferation, survival, metastasis angiogenesis in hepatocellular carcinoma (HCC). Here, we have investigated whether emodin mediates its effect through interference with the pathway HCC.The on activation, associated protein kinases apoptosis was using various HCC cell lines. Additionally, also used a predictive tumour technology to analyse effects . The vivo were assessed an orthotopic mouse model HCC.Emodin suppressed...
Nano-copper oxides are a versatile inorganic material. As result of their versatility, the immense applications and usage end up in environment causing concern for lifespan various beings. The ambiguities surround globally on toxic effects copper oxide nanoparticles (CuO-NPs). Hence, present study endeavored to sub-lethal acute exposure developing zebrafish embryos. 48 hpf LC50 value was about 64 ppm. Therefore, we have chosen dose 40 60 ppm study. Accumulation CuO-NPs evidenced from SEM-EDS...
ABSTRACT The aim of this study was to determine whether repeated exposure iron oxide nanoparticles (Fe 2 O 3 ‐NPs) could be toxic mice testis. Fe ‐NPs (25 and 50 mg/kg) were intraperitoneally administered into once a week for 4 weeks. Our showed that have the ability cross blood‐testis barrier get findings resulted in accumulation which evidenced from content Furthermore, 25 mg/kg administration increased reactive oxygen species, lipid peroxidation, protein carbonyl content, glutathione...
Accumulating evidence(s) indicate that CXCL12-CXCR4 signaling cascade plays an important role in the process of invasion and metastasis accounts for more than 80% deaths hepatocellular carcinoma (HCC) patients. Thus, identification novel agents can downregulate CXCR4 expression its associated functions have a great potential treatment metastatic HCC. In present report, we investigated anthraquinone derivative, emodin ability to affect as well function HCC cells. We observed downregulated...
The effect of fisetin on autophagy in hepatocellular carcinoma remains uncovered. HepG2 cells were exposed to different concentrations (25, 50, and 100 µM) for 24 h. also treated with rapamycin chloroquine alone or combination fisetin. Autophagic flux formation ATP levels determined. changes autophagic markers AMPK signaling proteins analyzed using qRT-PCR Western blotting. Cyto-ID staining followed by flow cytometry showed that decreased a dose-dependent manner. In gene expression analysis,...
Abstract Fluoride induced hepatotoxicity has been extensively studied in both humans and animals. However, the mechanism underlying of experimental fluorosis remains obscure. The severity fluoride toxicity was reduced by oral administration certain plant derived antioxidants. Caffeic acid (CA) a polyphenolic compound diverse range pharmacological activity biological system. Therefore, present study aimed to investigate protective CA, against rats. rats were treated with 300 ppm NaF via...