A5043791424- Sirtuins and Resveratrol in Medicine
- Cancer-related molecular mechanisms research
- Nanoparticles: synthesis and applications
- Aquaculture disease management and microbiota
- Neurogenesis and neuroplasticity mechanisms
- TGF-β signaling in diseases
- Hereditary Neurological Disorders
- Insect Pest Control Strategies
- Extracellular vesicles in disease
- Health, Environment, Cognitive Aging
- Bone Metabolism and Diseases
- Metabolomics and Mass Spectrometry Studies
- Diverse Scientific Research Studies
- Cholesterol and Lipid Metabolism
- RNA regulation and disease
- Insect Resistance and Genetics
- Antimicrobial agents and applications
- Neurobiology and Insect Physiology Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Genetics and Neurodevelopmental Disorders
- Spectroscopy Techniques in Biomedical and Chemical Research
- Aquatic life and conservation
- Virus-based gene therapy research
- Adipose Tissue and Metabolism
University of Saskatchewan
2015-2021
Myelination is controlled by timely expression of genes involved in the differentiation oligodendrocyte precursor cells (OPCs) into myelinating oligodendrocytes (OLs). Sirtuin 2 (SIRT2), a NAD+-dependent deacetylase, plays critical role OL promoting both arborization and downstream myelin-specific genes. However, mechanisms regulating SIRT2 during development are largely unknown. The RNA-binding protein quaking (QKI) an important myelination post-transcriptionally several myelin specific In...
Runt-related transcription factor 2 (Runx2) is a master regulator of osteogenic differentiation, but most the direct downstream targets RUNX2 during osteogenesis are unknown. Likewise, High-temperature requirement A1 (HTRA1) serine protease expressed in bone, yet role Htra1 osteoblast differentiation remains elusive. We investigated and transcriptional regulation by primary mouse mesenchymal progenitor cells.Overexpression was carried out cells to evaluate extent differentiation....
We have previously found that Sirt2 enhanced the outgrowth of cellular processes and MBP expression in CG4 cells, where is suppressed by transcription factor Nkx2.2. However, detailed mechanism facilitating oligodendroglial cell differentiation remained unclear. In present study, we observed partially translocated into nuclei when cells were induced to differentiate. was detected at CpG island PDGFRα promoter via ChIP assay during process rather than state growth. deacetylated protein(s)...
The biodegradable nanoparticles of chitosan have received a significance attention as potential drug delivery vehicles in the recent decades. present study was carried out to extract from shrimp shell waste and characterized followed by its antibacterial activity. Pure (CNP) tetracycline coated (TCNP) were prepared ionotropic gelation process. characterised UV visible spectrophotometer, SEM, XRD, FTIR, NMR, Nano size - Zeta analysis. Antibacterial activity assessed using CNP TCNP against 7...