Polycyclic aromatic hydrocarbons (PAHs) are a group of compounds consisting two or more fused rings. Most them formed during incomplete combustion organic materials such as wood and fossil fuels, petroleum products, coal. The composition PAH mixtures varies with the source is also affected by selective weathering effects in environment. PAHs ubiquitous pollutants frequently found variety environments fresh water marine sediments, atmosphere, ice. Due to their widespread distribution,...

Colorectal cancer (CRC) is a frequently diagnosed that primarily affects the digestive system and an imperative cause of mortalities worldwide. In this work, we formulated Tin oxide-Sodium alginate-Polyethylene glycol-Allyl isothiocyanate nanocomposites (SAP-Ally-NCs) investigated its anticancer role against DMH-provoked CRC in rats. The SAP-Ally-NCs were characterized different techniques. was provoked to rats via injecting 20 mg/kg DMH then administered with for 16 weeks. bodyweight...

Development of drugs from natural products has been undergoing a gradual evoluation. Many plant derived compounds have excellent therapeutic potential against various human ailments. They are important sources especially for anticancer agents. A number promising new agents in clinical development based on their selective molecular targets the field oncology. D-pinitol is naturally occurring compound soy which significant pharmacological activitites. Therefore we selected order to evaluate...

Objective: To evaluate the antioxidant and antidiabetic mechanism(s) of ethyl acetate extract fraction Moringa oleifera (M. oleifera) leaves on streptozotocin-induced diabetes in male Sprague-Dawley rats. Methods: A total 24 adult rats were segregated randomly into four groups (6 each group). Streptozotocin-induced given (oral gavage) M. (200 mg/kg b.w.) for 30 d. The control experimental sacrificed after hours final dose treatment, to blood pancreatic tissue biochemical histopathological...

Aim of the Study: In present study effects mangiferin were tested against lung cancer-bearing mice in both pre-initiation and post-initiation periods. Materials Methods: Healthy male Swiss albino (6-8 weeks old) used throughout study. The animals treated with (100 mg/kg body weight dissolved corn oil) two before (pre-initiation) twelfth week after (post-initiation) establishment B (a) P (50 weight)-induced carcinoma. Results: decreased levels xenobiotic liver marker enzymes markedly...

Diosgenin, a natural steroidal saponin, has been reported to be found predominantly in fenugreek and diverse biological properties. N-Methyl-N-nitrosourea (NMU) is mammary gland−specific carcinogen that closely mimics human breast cancer many aspects. The aim of this study was investigate the anticarcinogenic property diosgenin with reference lipid peroxidation, status antioxidants, activities marker enzymes against NMU-induced experimental carcinogenesis. Breast induced female Sprague...

Colon cancer is considered as the precarious forms of in many developed countries, with few to no symptoms; tumor often diagnosed later stages cancer. Monoterpenes are a major part plant essential oils found largely fruits, vegetables and herbs. The cellular molecular activities show therapeutic progression that may reduce risk developing by modulating factors responsible for colon carcinogenesis. was induced DMH dose (20 mg/Kg/body weight) 15 weeks subcutaneous injection once week. Myrtenal...

Nanotechnology has been materialized as a proficient technology for the development of anticancer nanoparticles all way through an environment-friendly approach. Conventionally, have assembled by dissimilar methods, but regrettably rely on negative impact natural environment. Amalgamation means plant extract is alternate conservative methods. In present study, we equipped gold (AuNPs) from Strychni semen; displayed less toxic and environment-friendly. Integration AuNPs was famed...

To investigate whether D-pinitol efficiently scavenge free radicals using various in vitro models [1, 1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide, superoxide anion and total antioxidant activity] vivo models. Female Sprague-Dawley rats (150-160 g) were divided into four groups each group consisting of six animals. Group I IV vector drug control. The II III animals treated with 7, 12-dimethylbenz(a)anthracene (DMBA) 20 mg/kg body weight to induce mammary carcinoma. Rats received cancer...

Parkinson's disease (PD) is the second most common neurodegenerative worldwide. Tomentosin an active compound isolated from I. viscosa plant that has extensive therapeutic value. In this exploration, neuroprotective actions of tomentosin were investigated against MPTP-stimulated neuroinflammation in mice. PD was stimulated C57/BL6 mice by injecting 20-mg/kg MPTP at 2-h intervals 4 times a day for 15 days simultaneously with treatment. The rota-rod test, grasping and pole climbing test...

Abstract The untreated systemic chronic inflammation leads to autoimmune diseases, hyperglycemia, cardiovascular type 2 diabetes, hypertension, osteoporosis, and so on. Phytochemicals effectively inhibit the inflammation, numerous studies have proved that phytocomponents possess anti‐inflammatory property via inhibiting cyclooxygenase lipoxygenase signaling pathways. Rhaponticin is one such phytochemical obtained from perennial plant Rheum rhaponticum L. belonging Polygonaceae family. We...

Abstract Among cancers, leukemia is a multistep progression that involves genetic modifications of normal hematopoietic progenitor cells to cancerous cells. In recent times, cases and their mortality rate have increased rapidly. Therefore, the immense need for therapeutic approach crucial can control this type cancer. Phyllanthin lignan compound constituent from Phyllanthus species has numerous beneficial effects as dietary component. The present study aims determine impact phyllanthin on...

Abstract: Background: Epilepsy, which affects about 1% of the world's population, is third most common neurological disease after stroke and Alzheimer's disease. It characterized by recurrent spontaneous seizures due to abnormal neuronal excitability hypersynchrony. Objectives: The current work was aimed at discovering neuroprotective properties ruscogenin against Pentylenetetrazole (PTZ)-induced epilepsy in rats. Materials Methods: epileptic episode induced rats injecting 45 mg/kg PTZ. Rats...