A5072491192- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ovarian function and disorders
- Systemic Lupus Erythematosus Research
- Endometriosis Research and Treatment
- Immunotherapy and Immune Responses
- Glioma Diagnosis and Treatment
- Eosinophilic Esophagitis
- Neonatal Respiratory Health Research
- Reproductive Health and Technologies
- Air Quality and Health Impacts
- Medical Imaging and Pathology Studies
- Metabolomics and Mass Spectrometry Studies
- Lung Cancer Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Lung Cancer Treatments and Mutations
- Sperm and Testicular Function
- Pediatric health and respiratory diseases
- Prenatal Screening and Diagnostics
- Climate Change and Health Impacts
- Occupational and environmental lung diseases
Shanghai Chest Hospital
2023-2025
Shanghai Jiao Tong University
2023-2025
Zhongshan Hospital
2018-2024
Fudan University
2018-2024
Tongji Hospital
2023-2024
Huazhong University of Science and Technology
2020-2024
Transient receptor potential (TRP) ankyrin 1 (TRPA1) could mediate ozone-induced lung injury. Optic Atrophy (OPA1) is one of the significant mitochondrial fusion proteins. Impaired fusion, resulting in dysfunction and ferroptosis, may drive onset progression In this study, we examined whether TRPA1 mediated bronchial epithelial cell injury by activating PI3K/Akt with involvement OPA1, leading to ferroptosis. Wild-type, TRPA1-knockout (KO) mice (C57BL/6 J background) ferrostatin-1...
Chronic obstructive pulmonary disease (COPD) is a highly heterogeneous disease, and metabolomics plays hub role in predictive, preventive, personalized medicine (PPPM) related to COPD. This study thus aimed reveal the of induced sputum predicting COPD severity. In this pilot study, total 20 patients were included. The metabolites assayed using liquid chromatography-mass spectrometry (LC-MS/MS) system. Five oxidative stress products (myeloperoxidase (MPO), superoxide dismutase (SOD),...
Objective Multiple morphological abnormalities of the sperm flagella (MMAF) is characterized by abnormal flagellar phenotypes, which a particular kind asthenoteratozoospermia. Previous studies have reported comparable intracytoplasmic injection (ICSI) outcome in terms fertilization rate and clinical pregnancy patients with MMAF compared those no MMAF; however, others conflicting opinions. Assisted reproductive technology (ART) outcomes individuals are still controversial open to debate....
Asthma is a highly heterogeneous disease. Metabolomics plays pivotal role in the pathogenesis and development of asthma. The main aims our study were to explore underlying mechanism asthma identify novel biomarkers through metabolomics approach.
Glucocorticoid (GC) insensitivity is an important feature of severe and fatal asthma. Oxidative stress can induce phosphoinositide-3-kinase (PI3K) activation, contributing to the development GC in chronic airway diseases. However, underlying molecular mechanism PI3K pathogenesis asthma remains unknown.We isolated peripheral blood mononuclear cells (PBMCs) from 34 participants (12 patients with mild/moderate asthma, 10 12 control subjects). H2O2 was used stimulate human macrophage line U937...
It is known that small airway disease present across all asthma severities; however, its prevalence and clinical characteristics in cough variant (CVA) have not been fully illuminated.A total of 77 CVA patients with preserved proximal function (FEV1/FVC > 70%) were enrolled this study. The correlation between forced expiratory flow at 50% (FEF50%) FEF25-75% the population was first evaluated. FEF50% determined to be an easy feasible parameter for identifying disease. defined as < 70%,...
Background Systemic lupus erythematosus (SLE) is often associated with adverse reproductive outcomes. But it’s currently unclear regarding the role of SLE in oocyte and embryonic development. Also, controversial whether has an effect on fertility. There a lack comprehensive understanding assessment fertility patients SLE. Objective This study was aim to investigate development as well ovarian reserve, clinical outcomes during vitro fertilization (IVF) treatment. By combining data gamete...
Abstract Background: Interleukin‐27 (IL‐27) modulates CD4+ T‐cell differentiation and function. The aim of this study is to investigate the effect molecular mechanisms IL‐27 on development asthma. Methods: was intranasally administered in an ovalbumin‐induced asthma model, lung mononuclear cells different Th cell classes were detected by fluorescence‐activated sorting. human bronchial epithelial (HBE) investigated measuring changes chemotactic factors, cytokines, transcription signaling...
Previous studies have shown that lipopolysaccharide (LPS)-activated bone marrow-derived dendritic cells (DClps) might induce tolerance in autoimmune and cancer models
The progression of an abnormal inflammatory response plays a crucial role in the lung function decline chronic obstructive pulmonary disease (COPD) patients. Compared to serum biomarkers, biomarkers induced sputum would be more reliable reflection processes airways.A total 102 COPD participants were divided into mild-to-moderate group (FEV1%pred≥ 50%, n=57) and severe-to-very-severe (FEV1%pred<50%, n=45). We measured series analyzed their association with SGRQ To evaluate relationship...
Early diagnosis and proper management of a large number chronic obstructive pulmonary disease (COPD) patients are great challenges for the Chinese health care system. Although tiered medical services have been promoted by government since 2015, they not ideally implemented COPD management.We designed cross-sectional study. Eligible (n = 648) physicians 161) were consecutively recruited from 8 hospitals in different tiers China. characteristics treatments compared among tiers. Multivariate...
The current asthma therapies are inadequate for many patients with severe asthma. Pyrroloquinoline quinone (PQQ) is a naturally-occurring redox cofactor and nutrient that can exert multitude of physiological effects, including anti-inflammatory antioxidative effects. We sought to explore the effects PQQ on allergic airway inflammation reveal underlying mechanisms. In vitro, secretion epithelial-derived cytokines by house dust mite- (HDM-) incubated 16-HBE cells differentiation potential CD4+...
Abstract Purpose To investigate the prognostic value of quantitative analysis CT among patients with idiopathic pulmonary fibrosis (IPF) by quantifying extent and to attempt provide precise medium-long term predictions for individual patients. Methods This was a retrospective cohort study that included 95 IPF in Zhongshan Hospital, Fudan University. 64 firstly diagnosed from 2009 2015 as derivation cohort. Information regarding sex, age, Gender-Age-Physiology (GAP) index, high-resolution...
Abstract Previous studies investigating the relationship between systemic lupus erythematosus (SLE) and primary ovarian failure (POF) generated conflicting results. To data, no mendelian randomization study has been applied to examine this association. In study, genetic instruments for exposure were selected from a GWAS with 5201 cases 9066 noncases. Outcome data POF three reproductive traits (age at menarche, age menopause, first live birth) obtained other eligible GWASs. estimate causal...
Abstract Background Primary Sjögren syndrome (pSS) is often related to adverse neonatal outcomes. But it’s currently controversial whether pSS has an effect on female fertility and clinical pregnancy condition. More importantly, unclear regarding the role of in oocyte embryonic development. There a lack comprehensive understanding evaluation patients. Objective This study aimed investigate development, ovarian reserve, outcomes patients during vitro fertilization (IVF) treatment from...
Recryopreservation (recryo) is occasionally applied in clinical, while the underlying mechanism of impaired clinical outcomes after recryo remains unclear. In this study, frozen embryo transfer (FET) cycles single blastocyst an academic reproductive medicine center were enrolled. According to number times blastocysts experienced cryopreservation, they divided into cryopreservation (Cryo) group and Recryo group. Donated human collected detected for exploration. It was found that procedure...
Abstract Introduction Previous studies have established a link between gut microbiota and polycystic ovary syndrome (PCOS), but little is known about their precise causal relationship. Therefore, this study aims to explore whether there are relationships PCOS. Material Methods We performed bidirectional two‐sample Mendelian randomization (MR) analysis. Datasets were from the largest published meta‐analysis on composition FinnGen cohort of IEU Open Genome‐Wide Association Study Project...
Secondary organizing pneumonia (OP) is associated with other pathological conditions, such as infections, drugs, cancers and radiotherapy. Lung cancer-associated secondary OP has rarely been reported. In this study, we reported on a case of caused by lung cancer. The patient was initially diagnosed community-acquired then cryptogenic CT scan-guided transbronchial biopsy. Poor response to anti-infection or corticosteroid therapy prompted us search for underlying disease. A TBNA biopsy the 4R...
Abstract Airway dendritic cells (DCs) are recognized as important factors in the mechanisms of allergic inflammatory diseases. Suppressor cytokine signaling 3 (SOCS3) is involved regulating functions T and macrophages, but roles SOCS3-expressing DCs pathogeneses diseases still controversial. We compared effects adoptively transferred SOCS3 −/− +/+ bone marrow-derived (BMDCs) on airway inflammation ovalbumin (OVA)-sensitized asthmatic mice. Adoptive transfer mature (lipopolysaccharide...