A5100690575- Microbial Natural Products and Biosynthesis
- Fungal Biology and Applications
- Andrographolide Research and Applications
- Toxin Mechanisms and Immunotoxins
- Plant biochemistry and biosynthesis
- Peanut Plant Research Studies
- Carbohydrate Chemistry and Synthesis
- Bone health and osteoporosis research
- Epilepsy research and treatment
- Drug Transport and Resistance Mechanisms
- Climate variability and models
- Galectins and Cancer Biology
- Probiotics and Fermented Foods
- Antibiotics Pharmacokinetics and Efficacy
- Biomarkers in Disease Mechanisms
- Transgenic Plants and Applications
- Plant Water Relations and Carbon Dynamics
- Adenosine and Purinergic Signaling
- Antibiotic Resistance in Bacteria
- Bone health and treatments
- Biochemical and biochemical processes
- Polysaccharides and Plant Cell Walls
- Genetic and Kidney Cyst Diseases
- DNA and Nucleic Acid Chemistry
- Ectopic Pregnancy Diagnosis and Management
China West Normal University
2025
Ministry of Agriculture and Rural Affairs
2022-2025
China Agricultural University
2022-2025
Beijing University of Chinese Medicine
2024
Guiyang Medical University
2024
Jiangsu University
2024
Wuhan Children's Hospital
2018-2023
Huazhong University of Science and Technology
2018-2023
Wuhan National Laboratory for Optoelectronics
2023
Center for Excellence in Molecular Plant Sciences
2022-2023
Abstract Allergic contact dermatitis (ACD) and atopic (AD) are the most common human skin disorders. Although corticosteroids have been widely used to treat ACD AD, side effects of encourage researchers explore new immunoregulatory treatments. Here, an immunomodulatory approach based on lipid nanoparticles carrying α ‐helical configurational melittin ( ‐melittin‐NP) is developed overcome T cell‐mediated inflammatory reactions in oxazolone (OXA)‐induced hypersensitivity mouse model...
Epilepsy is a neurological disease and approximately 30% of patients have failed to respond current anti-epilepsy drugs. The neuroinflammation mechanism has raised increasing concerns been regarded as the novel treatment strategy in epilepsy, but target molecules require further research. Pyruvate kinase isoform 2 (PKM2) well studied peripheral inflammation, its role epilepsy remains unclear. We knocked down microglia PKM2 hippocampus using stereotaxic adeno-associated virus (AAV)...
Accumulating evidence strongly support the key role of NLRP3-mediated pyroptosis in pathogenesis and progression vascular endothelial dysfunction associated with diabetes mellitus. Various studies have demonstrated that activation or upregulation Silent Information Regulation 2 homolog (SIRT2) exerts inhibitory effect on expression NLRP3. Although 1,8-cineole has been found to protect against cardiovascular diseases, its mechanism diabetic angiopathy remain unknown. Therefore, aim this study...
Objective This study aims to investigate the relationship between exposure air pollution and adverse meteorological factors, risk of osteoporosis. Methods We diagnosed osteoporosis by assessing bone mineral density through Dual-Energy X-ray absorptiometry in 2,361 participants from Jiangsu, China. Additionally, we conducted physical examinations, blood tests, questionnaires. evaluated levels using grid data, considering various lag periods (ranging one five years) based on participants’...
Chemically synthesized DNA fragments are increasingly recognized as highly valuable tracers for investigating environmental pollution due to their inherent high specificity, sequence diversity, friendliness, stable migration, and detection sensitivity, outperforming traditional ion dye tracers. Despite advantages, a systematic approach generating suitable sequences, which is critical requirement preparing tracers, remains not fully developed. This study introduces an optimization generator...
Abstract Background Bone mineral density (BMD) and prevalence of osteoporosis may differ between urban rural populations. This study aimed to investigate the differences in BMD characteristics populations Jiangsu, China. Methods A total 2,711 participants aged 20 years older were included cross-sectional study. Multistage stratified cluster random sampling was used as strategy. measured by method dual-energy x-ray absorptiometry (DXA). Data collected through questionnaires/interview. values...
Alpha-fetoprotein (AFP)-producing adenocarcinoma from the gastrointestinal tract (APA-GI) is a rare type of highly malignant tumor with poor prognosis. It may originate any site along GI similar clinicopathological characteristics. As limited research had ever described characteristics APA-GI, present article intends to systemically investigate APA-GI single center's retrospective study deepen understanding disease. A total 177 patients pathologically diagnosed between 2010 and 2017 at...
Fungal secondary metabolites with antibiotic activities can promote fungal adaptation to diverse environments. Besides the global regulator, individual biosynthetic gene clusters (BGCs) usually contain a pathway-specific transcription factor for tight regulation of metabolism. Here, we report chemical biology mediated by supercluster containing three BGCs in entomopathogenic fungus Metarhizium robertsii. These are jointly controlled an embedded that orchestrates collective production four...
Problem The aim of this research was to investigate the effects intrauterine perfusion hCG before a frozen‐thawed embryo transfer ( FET ) in women with different implantation failure numbers. Method Study This retrospective analysis patients undergoing who received an injection 1000 IU transfer. groups included their first (A group, n = 26), second (B 122), and three or more failures (C 77). Corresponding control (no infusion) were also included. pregnancy rates compared among these groups....
ApUGT, a diterpene glycosyltransferase from Andrographis paniculata, could transfer glucose to the C-19 hydroxyl moiety of andrograpanin form neoandrographolide. This has broad substrate scope, and it can glycosylate 26 natural unnatural compounds different structural types. study provides basis for exploring glycosylation mechanism ent-labdane-type diterpenes plays an important role in diversifying structures used drug discovery.
This study was aimed at identifying genetic and non-genetic risk factors for valproic acid (VPA)-induced hyperammonaemia in Chinese paediatric patients with epilepsy. A total of 210 epileptic patients, treated VPA as monotherapy, were enrolled classified into control groups according to their blood ammonia level (cut-off value 50 μmol/L). Serum concentrations its major metabolites simultaneously determined by ultrahigh-performance liquid chromatography-tandem mass spectrometry. Six single...
Diverse β-carboline (βC) alkaloids are produced by microbes, plants, and animals with myriad bioactivities drug potentials. However, the biosynthetic mechanism of βCs remains largely elusive, especially regarding hydroxyl glucosyl modifications βCs. Here, we report presence bacterial-like Pictet–Spenglerase gene Fcs1 in entomopathogenic Beauveria fungi that can catalyze biosynthesis βC skeleton. The overexpression bassiana led to identification six methyl glycosides, termed bassicarbosides...
Andrographis paniculata is an important traditional medicinal herb in South and Southeast Asian countries with diverse pharmacological activities that contains various flavonoids flavonoid glycosides. Glycosylation can transform aglycones into more stable, biologically active structurally Here, we report three glycosyltransferases from the leaves of A. (ApUFGTs) presented wide substrate spectra for glycosylation exhibited multi-site on molecules. They acted 7-OH position A ring were able to...
Abstract Background Laparoscopic surgery, fast-track perioperative treatment and XELOX chemotherapy are effective strategies for shortening the duration of hospital stay cancer patients. This trial aimed to clarify safety efficacy multidisciplinary (FTMDT) model compared conventional surgery combined with in Chinese colorectal Methods was a prospective randomized controlled study 2 × balanced factorial design conducted at six hospitals. Patients group 1 received adjuvant chemotherapy....
Abstract Detailed analysis of the regulatory mechanism spermatogonia stem cell (SSCs) genesis can provide a novel strategy for application SSCs in fields transgenic animal production and regenerative medicine. Previous studies this study showed that WNT signaling positively regulate formation SSCs, but exact is not clear. Here, we predicted target gene Wnt/TCF7L2 pathway, namely TDRD1, by bioinformatics analysis. Functional revealed overexpression TDRD1 during RA‐induced vitro significantly...
The present study aimed to establish population pharmacokinetic models of latamoxef, as well its R- and S-epimers, generate findings guide the individualized administration latamoxef in pediatric patients. A total 145 in-hospital children aged 0.08–10.58 years old were included this study. Three S-epimers established. stability predictive ability final evaluated by utilizing goodness-of-fit plots, nonparametric bootstrapping, normalized prediction distribution errors. model was considered a...
Abstract AFP-producing gastrointestinal adenocarcinoma (APA-GI) is a rare type of cancer, typically with hepatoid differentiation, chemotherapy resistance and poor prognosis. As the mechanisms its AFP production differentiation remain unclear, present study aims to reveal pathogenesis APA-GI through genomic transcriptomic profile analysis. We firstly performed 200 × whole exome sequencing 29 8 non-APA-GI cases from our hospital, but found no significant difference in single nucleotide...