A5089989449- Tryptophan and brain disorders
- Gut microbiota and health
- Diet and metabolism studies
- Mental Health Research Topics
- Schizophrenia research and treatment
- Stress Responses and Cortisol
- Functional Brain Connectivity Studies
- Clostridium difficile and Clostridium perfringens research
- Gastrointestinal motility and disorders
- Folate and B Vitamins Research
- Pharmacological Effects and Toxicity Studies
- Treatment of Major Depression
- Macrophage Migration Inhibitory Factor
- Advanced Technology in Applications
- Bipolar Disorder and Treatment
- Digital Media and Visual Art
- Family Dynamics and Relationships
- Neuroendocrine regulation and behavior
- Flavonoids in Medical Research
- Cholesterol and Lipid Metabolism
- Health, psychology, and well-being
- Fatty Acid Research and Health
- Transcranial Magnetic Stimulation Studies
- Genetic Associations and Epidemiology
- Mental Health Treatment and Access
First Affiliated Hospital of Zhengzhou University
2016-2025
Zhengzhou University
2018-2024
Henan Province Water Conservancy Survey and Design Research
2024
China Building Materials Academy
2019
Beijing HuiLongGuan Hospital
2017
Preclinical studies have shown that the gut microbiota can play a role in schizophrenia (SCH) pathogenesis via gut-brain axis. However, its antipsychotic treatment response is unclear. Here, we present 24-week follow-up study to identify microbial biomarkers for SCH diagnosis and response, using sample of 107 first-episode, drug-naïve patients, healthy controls (HCs). We collected biological samples at baseline (all participants) time points after risperidone (SCH patients). Treatment was...
Abstract Background and Hypothesis Schizophrenia (SCZ) is associated with complex crosstalk between the gut microbiota host metabolism, but underlying mechanism remains elusive. Investigating aberrant neurotransmitter processes reflected by alterations identified using multiomics analysis valuable to fully explain pathogenesis of SCZ. Study Design We conducted an integrative data, including serum metabolome, fecal metagenome, single nucleotide polymorphism neuroimaging data obtained from a...
Depression and anxiety were not only common but also with serious consequence in infertility patients. The current study endeavors to define distinct depression profiles of patients identify central symptoms within different facilitate targeted interventions. research employed K-means Clustering delineate the profiles, followed by a repetition analysis using Latent Class Analysis (LCA). Furthermore, network was utilized various profiles. K‑means identified Cluster 1 (16.15%), 2 (37.08%) 3...
Background: Butyric acid, a major short-chain fatty acid (SCFA), has an important role in the microbiota–gut–brain axis and brain function. This study investigated of butyric treatment response drug-naïve first episode schizophrenia. Methods: The recruited 56 Chinese Han schizophrenia inpatients with normal body weight 35 healthy controls. Serum levels were measured using Gas Chromatography-Mass Spectrometer (GC-MS) analysis at baseline (for all participants) 24 weeks after risperidone...
The aim of the present study was to explore influencing factors cognitive impairments and their interrelationships in drug-naïve, first-episode schizophrenia (SCZ).Patients with drug naïve, first episode SCZ healthy controls (HCs) were enrolled. Cognitive function assessed by MATRICS Consensus Battery (MCCB). Serum levels oxidative stress indices, including folate, superoxide dismutase (SOD), uric acid (UA) homocysteine (Hcy), determined after an overnight fast. Hippocampal subfield volumes...
Background Schizophrenia (SCZ) is a heritable disorder with polygenic architecture, and the gut microbiota seems to be involved in its development outcome. In this study, we investigate interplay between genetic risk microbial markers. Methods We included 159 first-episode, drug-naïve SCZ patients 86 healthy controls. The composition of feces was characterized using 16S rRNA sequencing platform, five α-diversity indices were estimated [Shannon, Simpson, Chao1, Abundance-based Eoverage...
Objective: The present study aimed to examine whether insulin resistance and oxidative stress are associated with cognitive impairment in first-episode drug-free schizophrenia (SZ) patients. Methods: Ninety SZ patients 70 healthy controls were enrolled. Fasting (FINS) markers of [oxidized glutathione (GSSG), superoxide dismutase (SOD), nitric oxide (NO) uric acid (UA) levels] measured serum before pharmacological treatment was initiated. Psychiatric symptoms function assessed the Positive...
Objective: In this study, alterations in oxidative stress-related indicators were evaluated drug-naïve, first-episode schizophrenia (SCZ) patients, and the effectiveness of blood serum glucose, superoxide dismutase (SOD), bilirubin objective assistive diagnosis was explored. Materials methods: We recruited 148 SCZ patients 97 healthy controls (HCs). Blood biochemical indexes including SOD, homocysteine (HCY) participants measured, compared between with HCs. The diagnostic model for...
Abstract Various psychosocial and psychological interventions have been developed to reduce schizophrenia relapse prevention. A better understanding of these active is important for clinical practice meaningful allocation resources. However, no bibliometric analysis this area has conducted. Studies were retrieved from the Web Science Core Collection database. The publication outputs cooperation institutions visualized with Origin 2021. Global was using ArcGIS Pro3.0. VOSviewer used generate...
This study has employed network analysis while investigating the interrelationships among stress and stigma symptoms their associations with quality of life Chinese female infertility patients. In this cross-sectional study, 428 patients who visited Department Reproductive Center Dalian Women Children's Medical Group chief complaints were recruited using convenience sampling from November 2022 to December 2023. Fertility-related status examined by Fertility Problem Inventory (FPI)...
To explore hormone such as follicle-stimulating (FSH), luteinizing (LH), prolactin (PRL), estradiol (E2), progesterone (PROG) and testosterone (TESTO) levels in first-episode drug-free schizophrenics, the relationship between clinical symptoms sex hormones, order to further study pathogenesis of schizophrenia.Eighty-one schizophrenics including thirty-nine male forty-two female from First Affiliated Hospital Zhengzhou University seventy healthy subjects (thirty forty female) were...
Recent studies have proved that dynamic regional measures extracted from the resting-state functional magnetic resonance imaging, such as fractional amplitude of low-frequency fluctuation (d-fALFF), could provide a great insight into brain characteristics schizophrenia. However, unimodal feature is limited for delineating complex patterns deficits. Thus, and structural imaging data are usually analyzed together uncovering neural mechanism Investigation function-structure coupling enables to...
Objective: To observe the relationship between serum oxidative stress as well brain-derived neurotrophic factor (BDNF) and cognitive function in first-episode drug-free schizophrenics, to explore possible effect of impairment schizophrenia. Methods: A total 125 schizophrenics (schizophrenia group) from First Affiliated Hospital Zhengzhou University 80 healthy individuals (control were enrolled. The concentration oxidized glutathione (GSSG) was measured by Microenzyme method nitric oxide (NO)...