A5100349256- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Cancer-related molecular mechanisms research
- Eosinophilic Esophagitis
- Chronic Lymphocytic Leukemia Research
- Neonatal and Maternal Infections
- Mosquito-borne diseases and control
- Gastrointestinal disorders and treatments
- Cerebrovascular and Carotid Artery Diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- Nutritional Studies and Diet
- Neurological Disease Mechanisms and Treatments
- Streptococcal Infections and Treatments
- Aquaculture disease management and microbiota
- Dementia and Cognitive Impairment Research
- Cutaneous lymphoproliferative disorders research
- Vibrio bacteria research studies
- Respiratory Support and Mechanisms
- Cardiovascular Disease and Adiposity
- Immune cells in cancer
- Microscopic Colitis
- Studies on Chitinases and Chitosanases
- Cancer, Stress, Anesthesia, and Immune Response
- Autophagy in Disease and Therapy
First People’s Hospital of Zunyi
2021-2025
Zunyi Medical University
2016-2025
Hunan Cancer Hospital
2018-2024
Affiliated Hospital of North Sichuan Medical College
2022-2023
Central South University
2014-2023
Nanjing University of Chinese Medicine
2023
Zhengzhou University
2022
First Affiliated Hospital of Zhengzhou University
2022
Wuhan University
2022
Ningxia Medical University
2019-2022
Background and Aims: Cholesterol ester (CE) biosynthesis homeostasis play critical roles in many cancers, including HCC, but their exact mechanistic contributions to HCC disease development require further study. Approach Results: Here, we report on a proposed role of tumor suppressor P53 its repressing ubiquitin‐specific peptidase 19 (USP19) sterol O‐acyltransferase (SOAT) 1, which maintains CE homeostasis. USP19 enhances cholesterol esterification contributes hepatocarcinogenesis (HCG) by...
In previous studies, we confirmed that the overexpression of lncRNA NORAD was associated with occurrence and development gastric cancer (GC). The aim present study to explore molecular mechanism on GC cell proliferation apoptosis in vitro vivo.
Increased evidence reveals that glycolysis is one of the key metabolic hallmarks cancer cells. However, roles lncRNA FTX in energy metabolism and progression remain unclear. In this study we aim to show was significantly upregulated tissues serum CRC patients cell lines. Function indicated it could promote aerobic glycolysis, proliferation, migration invasion colorectal Further mechanistic studies showed, found function as a sponge for miR-215-3p, which reduced ability miR-215-3p repress...
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease of unknown etiology. The emerging evidence demonstrates that metabolic homeostatic imbalance caused by repetitive injuries the alveolar epithelium potential pathogenesis IPF. Proteomic analysis identified Acetyl-CoA synthetase short chain family member 3 (ACSS3) expression was decreased in IPF patients mice with bleomycin-induced fibrosis. ACSS3 participated lipid carbohydrate metabolism. Increased...
Mosquito-borne diseases affect over half of the human population globally. Multiple studies have shown that chemical insecticides are ineffective because resistance. Therefore, environmentally safe mosquito control tools need to be developed. Ribonucleic acid interference (RNAi) is a reverse genetic mechanism recently introduced as new pest tool. This technique represents class biorational technology could combat increased global incidence insecticide The has potential becoming critical...
New biocontrol strategies are urgently needed to combat vector-borne infectious diseases. This study presents a low-cost method produce potential mosquito insecticide that utilizes the microalgae released into suburban water sources control populations. Chlorella ubiquitous in local waters, which were chosen as host for genetic transfection. species facilitated recombinant algae adapt prevailing environmental conditions with rapid growth and high relative abundance. The procedure involved...
Systemic Epstein-Barr virus-positive T-cell lymphoproliferative childhood disease (EBV+T-LPD) is extremely rare. Primary acute or chronic active virus infection triggers EBV+T-LPD's onset and the involves clonal proliferation of infected T-cells with activated cytotoxic phenotype. The adult-onset EBV+T-LPD (ASEBV+T-LPD) even rarer needs to be extensively studied. Further, according literature review, it a challenge find patients who are immunocompetent diagnosed ASEBV+T-LPD involving...
Purpose: Adiposity is one of the important determinants blood pressure. The aim this study to evaluate association between pressure and body composition indices throughout whole lifespan healthy adults. Patients methods: This was from an ongoing cross-sectional survey Chinese health wherein data included basic physiological parameters. Partial Pearson correlation analysis used assess indices. Multiple linear regression mass index, lean percent visceral fat rating against in each age group....
Patients with subcortical ischemic vascular disease (SIVD) suffer from memory disorders that are thought to be associated the hippocampus. We aimed explore changes in hippocampal subfields and relationship between different subfield volumes types of dysfunction SIVD patients.A total 77 patients cognitive impairment (SIVD-CI, n = 39) or normal cognition (HC-SIVD, 38) 41 matched healthy controls (HCs) were included this study. Memory function was measured all subjects, structural magnetic...
Background Cadonilimab (AK104) is a bispecific IgG-single-chain Fv fragment (ScFv) antibody that binds to PD-1 and CTLA-4. has shown encouraging anti-tumour activity favourable safety profile in several tumour types. In second-line treatment, there no defined standard of care for patients with extensive-stage small-cell lung cancer (ES-SCLC). expected show substantial clinical efficacy. Objective To assess the antitumor cadonilimab monotherapy or combination conventional therapy ES-SCLC who...
Abstract Aim To investigate the value of ultrasonography ( US ) for diagnosing synovitis associated with rheumatoid arthritis RA ). Method Bilateral metacarpophalangeal MCP ), proximal interphalangeal PIP II – V and wrist joints 46 patients 35 healthy controls were evaluated by quantitative semiquantitative . Wrists on more severely affected sides 20 also underwent magnetic resonance imaging MRI The results compared. cutoff to distinguish pathology was calculated. two methods compared...
Periprosthetic osteolysis (PPO), caused by wear particles, has become a major cause of joint replacement failure. Secondary surgery after poses serious threat to public health worldwide. Therefore, determining how effectively inhibit particle-induced PPO an urgent issue. Recently, the interaction between osteogenic inhibition and particles at biological interface implant been found be important factor in pathological process. Previous studies have that central nervous system plays role...
This study is aimed to investigate the mechanisms of radiation-induced mouse models premature ovarian insufficiency (POI). Wistar female rats were grouped into control, 3.2 Gy, 4.0 and 4.8 Gy groups. Overall functions assessed with H&E staining ELISA. Proinflammatory cytokine secretion was analyzed ELISA, reactive oxygen species (ROS) levels immunohistochemistry. Protein expressions by Western blot analysis. The groups had significantly lower weight coefficients than control (after only one...
The study aimed to explore the independent association between expanded normal weight obesity categories and blood pressure among adults aged 20-80 years in China. By cross-sectional design, a total of 4279 living Shaanxi Province, China, were selected from communities via multi-stage stratified cluster sampling 2014. Information on anthropometric, body composition was collected analysed. Expanded (ENWO) used identify level bodyweight based combination mass index (BMI) fat percentage (BFP)...
Gastric cancer (GC) is a common type of digestive with high morbidity and mortality rates worldwide. Considerable effort has been expended in understanding the mechanism GC development metastasis. The current study therefore explores involvement microRNAs regulation progression.To explore expression function miR-30e-3p development.MiR-30e-3p was found to be downregulated GC, low levels thereof predicting poor outcomes among patients GC. Functionally, we revealed that suppressed cell growth...
Previous studies have focused on the changes of dynamic and static functional connections in cerebral small vessel disease (CSVD). However, characteristics local brain activity are poorly understood. The purpose this study was to investigate patients with CSVD using amplitude low-frequency fluctuation (d-ALFF).A total 104 cognitive impairment (CSVD-CI, n = 52) or normal cognition (CSVD-NC, 63 matched healthy controls (HCs) were included study. Every participant underwent magnetic resonance...
BACKGROUND:This study compared clinical outcomes and adverse events between L-asparaginase/pegaspargase-based short-course long-course chemoradiotherapy in newly diagnosed stage IE–IIE extranodal natural killer/T cell lymphoma, nasal type (ENKTL). MATERIAL AND METHODS:Patients were categorized into a (2–4 chemotherapy cycles, median: 4, n=153) group (5–6 6, n=83). The regimens included GELOX, SMILE, VLP. radiotherapy dose was 40–63 Gy (median: 55 Gy). Adverse events, treatment responses,...