A5007234754- Plant-Microbe Interactions and Immunity
- Plant Pathogenic Bacteria Studies
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Tryptophan and brain disorders
- Immune cells in cancer
- MicroRNA in disease regulation
- Plant Molecular Biology Research
- Genetic Mapping and Diversity in Plants and Animals
- Stress Responses and Cortisol
- Plant Virus Research Studies
- Plant Gene Expression Analysis
- Epigenetics and DNA Methylation
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Genetics, Aging, and Longevity in Model Organisms
- Circular RNAs in diseases
- GABA and Rice Research
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Heavy Metals in Plants
- 14-3-3 protein interactions
- Nanocluster Synthesis and Applications
- Signaling Pathways in Disease
- Nuclear Receptors and Signaling
South China Agricultural University
2020-2025
First Affiliated Hospital of Anhui Medical University
2025
Anhui Medical University
2025
University of Macau
2024
Xinjiang Normal University
2024
Nanjing Drum Tower Hospital
2018-2023
Yunnan Academy of Agricultural Sciences
2009-2022
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2020-2022
Yunnan University
2020-2021
Second Affiliated Hospital of Xi'an Jiaotong University
2016
Neurotransmitters have been well documented to determine immune cell fates; however, whether and how γ-amino butyric acid (GABA) shapes the function of innate cells is still obscure. Here, we demonstrate that GABA orchestrates macrophage maturation inflammation. treatment during inhibits interleukin (IL)-1β production from inflammatory macrophages. Mechanistically, enhances succinate-flavin adenine dinucleotide (FAD)-lysine specific demethylase1 (LSD1) signaling regulate histone...
Intracellular metabolic programs tightly regulate the functions of macrophages, and previous studies have shown that serine mainly shapes macrophage function via one-carbon metabolism. However, it is unknown whether modulates independent Here, we find deprivation lowers interleukin (IL)-1β production inflammasome activation, as well reprograms transcriptomic profile in M1 macrophages. Intriguingly, supplementation formate, glycine, dNTPs, glucose cannot rescue IL-1β from serine-deprived...
Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism caused by loss-of-function mutations in ATP7B, which encodes a copper-transporting protein. It characterized excessive deposition tissues, predominantly the liver and brain. We sought to investigate whether gene-corrected patient-specific induced pluripotent stem cell (iPSC)-derived hepatocytes (iHeps) could serve as autologous source for cellular transplantation therapy WD.We first compared vitro phenotype...
Rice bacterial blight (BB), caused by Xanthomonas oryzae pv. (Xoo), is one of the devastating diseases rice. It well established that wild rice Oryza meyeriana immune to BB. In this study, transcriptomic analysis was carried out RNA sequencing O. leaves, inoculated with Xoo understand transcriptional responses and interaction between host pathogen. Totally, 57,313 unitranscripts were de novo assembled from 58.7 Gb clean reads 14,143 identified after inoculation. The significant metabolic...
Although various factors may contribute to its initiation and progression, the etiology prognosis of endometrial carcinoma (EC) remains not fully understood. We sought understand role changes in transcriptome during progress EC by exploring public datasets. The aberrant expression characteristics based on RNA-Seq miRNA-seq data from Cancer Genome Atlas ( TCGA ) were analyzed. Kaplan-Meier analysis was performed assess relationship between differently expressed genes DEGs patient survival. As...
Gut microbiota plays a vital role in host metabolism; however, the influence of gut microbes on polyamine metabolism is unknown. Here, we found germ-free models possess elevated levels colon. Mechanistically, intestinal
Intestinal microbes are closely associated with host health, depending on metabolic crosstalk between the microbiota and host. Tryptophan metabolism is one of best examples intestinal host; however, our understanding about influence tryptophan limited. Thus, we established germ-free (GF) pig models to systemically explore metabolism. Five GF pigs were kept in conditions throughout experiment (GF group). Six transplanted fecal from donor sows act as control pigs. Compared pigs, had remarkable...
Endometrial cancer (EC) is the most common gynecological tumor all over world, and advanced/metastatic EC remains a malignancy with poor survival outcome due to highly resistant conventional chemotherapeutic treatment. Here, we report that Aurora-A, serine-threonine kinase, plays vital role in chemoresistance of EC. Aurora-A overexpressed tissues, compared normal endometrium expression associated decreased overall survival. Overexpression cell lines (Ishikawa HEC-1B cells) promotes...
Oryza officinalis Wall ex Watt is one of the most important wild relatives cultivated rice and exhibits high resistance to many diseases. It has been used as a source genes for introgression into rice. However, there are limited genomic resources little genetic information publicly reported this species. To better understand pathways factors involved in disease accelerating process breeding, we carried out de novo transcriptome sequencing O. officinalis. In research, 137,229 contigs were...
Oryza officinalis Wall ex Watt, a very important and special wild rice species, shows abundant genetic diversity disease resistance features, especially high to bacterial blight. The molecular mechanisms of blight in O. have not yet been elucidated. WRKY transcription factor family is one the largest gene families involved plant growth, development stress response. However, little known about numbers, structure, phylogenetics, expression genes under Xanthomonas oryzae pv. (Xoo) due lacking...
Abstract Background Bacterial blight (BB) caused by Xanthomonas oryzae Pv. ( Xoo ) is one of the most serious diseases rice worldwide. Oryza officinalis Wall ex Watt, harboring abundant genetic diversity and disease resistance features, are important resources exploring genes with broad-spectrum to BB. However, molecular mechanisms BB in O. have been rarely explored. Results Here, four different origin populations Yunnan were identified seven representative hypervirulent races, which...
Abstract Bacterial blight (BB), a serious bacterial disease caused by pathogen Xanthomonas oryzae pv. ( Xoo ) affects rice growth and yield. Yunnan Province is regarded as center of diversity in China indeed the world, has abundant landrace resources, which may offer prospective candidate donors improvement breeding. In this study, set 200 landraces were evaluated to determine their resistance 10 pathogenic strains leaf-clipping method. The results indicated that tested had different levels...
With 2 tables and 6 figures Abstract Oryza meyeriana Baill was found immune to Xanthomonas oryzae pv. (Xoo). However, the genes responsible for strong resistance are unknown. In this study, suppression subtractive hybridization (SSH) utilized identify differentially expressed in O. after Xoo infection. plants inoculated with high pathogenicity races were used as ‘tester’ non-inoculated ‘driver’. Analysis of SSH library revealed cell wall lignifications, which may function block pathogen...
Dilated cardiomyopathy (DCM) is characterized by ventricular dilatation, and it a common cause of heart failure cardiac transplantation. This study aimed to explore potential DCM-related genes their underlying regulatory mechanism using methods bioinformatics. The gene expression profiles GSE3586 were downloaded from Gene Expression Omnibus database, including 15 normal samples 13 DCM samples. differentially expressed (DEGs) identified between Limma package in R language. Pathway enrichment...