A5101778699- Advanced Photocatalysis Techniques
- Supercapacitor Materials and Fabrication
- Nanoplatforms for cancer theranostics
- Advancements in Battery Materials
- X-ray Diffraction in Crystallography
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Crystallization and Solubility Studies
- Advanced Nanomaterials in Catalysis
- Advanced Sensor and Energy Harvesting Materials
- Corneal Surgery and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Cholinesterase and Neurodegenerative Diseases
- Conducting polymers and applications
- Nanoparticles: synthesis and applications
- MXene and MAX Phase Materials
- Catalytic Cross-Coupling Reactions
- Catalytic C–H Functionalization Methods
- Microencapsulation and Drying Processes
- Protein Degradation and Inhibitors
- Synthesis and Catalytic Reactions
- Advanced battery technologies research
- Cancer-related gene regulation
- Yersinia bacterium, plague, ectoparasites research
- Oxidative Organic Chemistry Reactions
Sun Yat-sen University Cancer Center
2020-2024
Sun Yat-sen University
2020-2024
Zhengzhou University
2020-2023
Northwest A&F University
2019-2021
Beijing Chest Hospital
2017
Capital Medical University
2017
Synergistic therapeutic strategies for bacterial infection have attracted extensive attentions owing to their enhanced effects and less adverse compared with monotherapy. Herein, we report a novel synergistic antibacterial platform that integrates the nanocatalytic therapy photothermal (PTT) by hemoglobin-functionalized copper ferrite nanoparticles (Hb-CFNPs). In presence of low concentration hydrogen peroxide (H2O2), excellent Fenton Fenton-like reaction activity Hb-CFNPs can effectively...
EZH2 inhibitors that prevent trimethylation of histone lysine 27 (H3K27) are often limited to the treatment a subset hematological malignancies. In most solid tumors, induce reciprocal H3K27 acetylation subsequently results in acquired drug resistance. The combination and BRD4 resensitize cancer cells has proven be effective, underlying significance developing dual inhibitors. Herein, we present design, synthesis, biological evaluation first-in-class EZH2/BRD4 Our promising compound, YM458,...
This work constructed a multifunctional nanoplatform based on positively charged copper manganate nanoflakes (CuMnO<sub>2</sub> NFs) for combined catalysis and photothermal sterilization.
As histone modification enzymes, EZH2 mediates H3K27 trimethylation (H3K27me3), whereas LSD1 removes methyl groups from H3K4me1/2 and H3K9me1/2. Synergistic anticancer effects of combining inhibitors these two enzymes are observed in leukemia prostate cancer. Thus, a series EZH2/LSD1 dual designed synthesized to evaluate their activity. After the structure–activity study, one best compounds, ML234, displayed excellent antiproliferative capacity against cancer cell lines LNCAP, PC3, 22RV1....
Cross-coupling reactions between aryl iodide and nucleophiles have been well developed. Iodoniums equipped with a reactive C-I(III) bond accelerate cross-coupling of iodide. Among them, cyclic diaryliodoniums are more atom economical; however; they often in the trap metal reliance encounter regioselectivity issues. Now, we developed series highly monoaryl-vinyl iodoniums that can be tuned to construct C-N, C-O, C-C bonds without catalysis. Under promotion triethylamine, coupling aniline,...
Background: To identify new bacterial type III secreted effectors is computationally a big challenge. At least dozen machine learning algorithms have been developed, but so far only achieved limited success. Sequence similarity appears important for biologists frequently neglected by algorithm developers effector prediction, although large success was in the field with this strategy decade ago. Objective: The study aimed to develop sequence based prediction tool. Method: In study, we propose...