A5035676413- Estrogen and related hormone effects
- Effects and risks of endocrine disrupting chemicals
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Hypothalamic control of reproductive hormones
- Regulation of Appetite and Obesity
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Animal testing and alternatives
- Menopause: Health Impacts and Treatments
- Neonatal Respiratory Health Research
- Electrolyte and hormonal disorders
- Hormonal Regulation and Hypertension
- Cholesterol and Lipid Metabolism
University of Illinois Chicago
2019-2024
Baton Rouge Clinic
2020
University of Iowa
2017
Estrogens promote binge alcohol drinking and contribute to sex differences in use disorder. However, the mechanisms are largely unknown. This study aims test if estrogens act on 5-hydroxytryptamine neurons dorsal raphe nucleus (5-HT
Oxysterols are metabolites of cholesterol that regulate homeostasis. Among these, the most abundant oxysterol is 27-hydroxycholesterol (27HC), which can cross blood-brain barrier. Because 27HC functions as an endogenous selective estrogen receptor modulator, we hypothesize binds to α (ERα) in brain energy balance. Supporting this view, found delivering reduced food intake and activated proopiomelanocortin (POMC) neurons arcuate nucleus hypothalamus (POMC
Abstract Bisphenol F (BPF) is increasingly substituting bisphenol A in manufacturing polycarbonates and consumer products. The cardiometabolic effects of BPF either humans or model organisms are not clear, no studies to date have investigated the role genetic background on susceptibility BPF-induced traits. primary goal this project was determine if exposure influences growth adiposity male N:NIH heterogeneous stock (HS) rats, a genetically population. Littermate pairs HS rats were randomly...
Summary The ovarian hormone estrogens promote binge alcohol drinking and contribute to sex differences in use disorder. However, the mechanisms for estrogen-induced are largely unknown. This study aims test if act on 5-hydroxytryptamine neurons dorsal raphe nucleus (5-HT DRN ) drinking. We used dark (DID) behavioral mice mimic humans. found that female drank more than male chronic DID tests. difference was associated with distinct alterations mRNA expression of estrogen receptor α (ERα)...
Though mid‐ and late‐gestational mechanisms of the late‐pregnancy cardiovascular disorder preeclampsia (PreE) are relatively well characterized, genetic risk factors driving early gestational pathogenesis PreE remain largely unclear. Various hormone activators Gαq second‐messenger signaling pathways (eg ‐ vasopressin, endothelin, angiotensin) have been implicated in preeclampsia. Regulator G‐protein Signaling 2 (RGS2) acts as an endogenous terminator signaling, previous association studies...
Previously we demonstrated that preeclampsia, a hypertensive disorder of pregnancy, is associated with elevated secretion arginine vasopressin (AVP) as early the sixth week gestation. In addition, chronic low‐dose infusion AVP into pregnant wildtype C57BL/6J sufficient to initiate all cardinal phenotypes preeclampsia including gestational‐dependent de novo hypertension, renal glomerular endotheliosis, placental hypoxia and intrauterine growth restriction. We hypothesize acts directly upon...
Bisphenol F (BPF) is marketed as a ‘safe’ substitute for bisphenol A (BPA), an endocrine disruptor associated with obesity and heart disease (i.e. cardiometabolic disease), in manufacturing polycarbonates common consumer products (e.g. food packaging). BPF's environmental presence growing rapidly detected over 85% of U.S. adults children. There evidence individual variation levels, suggesting that genetic or gene x environment (GxE) interactions influence risk due to exposure. Characterizing...
Compelling evidence has demonstrated that estradiol and estrogen receptor α/β (ERα/β) play key roles in the central regulation of energy balance glucose homeostasis. Our previous research showed ERα medial amygdala (ERαMeA) mediates estrogenic actions to stimulate physical activity, therefore promotes expenditure prevents diet-induced obesity (DIO). Interestingly, another receptor, ERβ, is also highly expressed MeA. To test metabolic functions ERβMeA, we generated a mouse model with ERβ...