A5101547034- HIV/AIDS drug development and treatment
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Biochemical and Molecular Research
- Liver Disease and Transplantation
- Pancreatitis Pathology and Treatment
- Long-Term Effects of COVID-19
- Tuberculosis Research and Epidemiology
- Glioma Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Chemical Synthesis and Analysis
- Brain Metastases and Treatment
- Computational Drug Discovery Methods
- Helicobacter pylori-related gastroenterology studies
- Infectious Aortic and Vascular Conditions
- Ureteral procedures and complications
- Kidney Stones and Urolithiasis Treatments
- Food composition and properties
- COVID-19 and healthcare impacts
- Phytoestrogen effects and research
- Cancer Treatment and Pharmacology
- Immune Response and Inflammation
Tongji University
2025
Tongji Hospital
2025
Southern Medical University
2024
Nanfang Hospital
2024
Shandong University
2020-2022
Shanghai Jiao Tong University
2020-2021
Shantou Central Hospital
2020-2021
LMU Klinikum
2021
München Klinik
2021
Beijing Tian Tan Hospital
2021
Heart failure, especially in the elderly, is a growing global issue. This research explores safety of human albumin infusion treating heart failure patients with hypoalbuminemia, despite limited clinical data on its use diuretic therapy. Data were collected from Medical Information Mart for Intensive Care III (MIMIC-III) database, which included cohort 6094 diagnosed failure. Propensity score matching, logistic regression, Kaplan-Meier curves, and Locally Weighted Scatterplot Smoothing...
Abstract Objectives The aim of the study was to analyze incidence COVID-19 with early renal injury, and explore value multi-index combined detection in diagnosis injury COVID-19. Design an observational, descriptive study. Setting This carried out a tertiary hospital Guangdong, China. Participants 12 patients diagnosed from January 20, 2020 February 2020. Primary secondary outcome measures primary evaluate In this study, estimated glomerular filtration rate (eGFR), endogenous creatinine...
Objective The aim of the study was to analyze characteristics renal function in patients diagnosed with COVID-19. Methods In this retrospective, single-center study, we included all confirmed cases COVID-19 a tertiary hospital Guangdong, China from January 20, 2020 March 2020. Blood and urine laboratory findings related functionwere summarized, estimated glomerular filtration rate (eGFR) endogenous creatinine clearance (Ccr) were also calculated assess function. Results A total 12 admitted...
Here, we report the design, synthesis, structure–activity relationship studies, antiviral activity, enzyme inhibition, and druggability evaluation of dihydrofuro[3,4-d]pyrimidine derivatives as a potent class HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs). Compounds 14b (EC50 = 5.79–28.3 nM) 16c 2.85–18.0 exhibited superior potency against panel HIV-1-resistant strains. Especially, for changeling mutations F227L/V106A K103N/Y181C, both compounds remarkably improved activity...
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent an indispensable part of anti-HIV-1 therapy. To discover novel HIV-1 NNRTIs with increased drug resistance profiles and improved pharmacokinetic (PK) properties, a series diarylpyrimidine derivatives were generated via the cocrystal structure-based design strategy. Among them, 36a exhibited outstanding antiviral activity against IIIB panel mutant strains (L100I, K103N, Y181C, Y188L, E138K, F227L + V106A, RES056), EC50 ranging...
Bacterial infections are prevalent and the major cause of morbidity mortality in cirrhosis. Activation human Kupffer cells (HKCs) from livers is essential for innate immunity. Cytosolic phospholipase A2 (cPLA2) plays a crucial role control balance immune inflammatory reactions. Uncharacterized cPLA2 HKC activation by bacterial infection. This work aimed to determine function mechanism gram-negative bacteria (GNB)-induced activation. In this study, we found that Escherichia coli (E....
Chronic liver diseases (CLDs) are complex that cause long-term inflammation and infection, which in turn accelerate their development. The usage of albumin patients with CLDs has been debated for years. Human serum (HSA) plays a key role immunomodulation during the process CLDs. correlation between C-reactive protein (CRP) CLD was analyzed by linear regression Pearson statistic. damage THP-1 primary cells evaluated measuring lactate dehydrogenase (LDH) supernatant. Immunofluorescence...
COVID-19 is an infectious disease caused by SARS-CoV-2. The life cycle of SARS-CoV-2 includes the entry into target cells, replicase translation, replicating and transcribing genomes, translating structural proteins, assembling releasing new virions. Entering host cells a crucial stage in early virus, blocking this can effectively prevent virus infection. SARS enters mediated interaction between viral S protein cell surface receptor angiotensin- converting enzyme 2 (ACE2), as well cleavage...
The emergence of the novel human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to pandemic coronavirus disease 2019 (COVID-19), which markedly affected global health and economy. Both uncontrolled viral replication a proinflammatory cytokine storm can cause tissue damage in patients with COVID-19. SARS-CoV-2 utilizes angiotensin-converting enzyme 2 (ACE2) as its entry receptor. In this study, we generated ACE2 extracellular domain-Fc single-chain variable...
In this study, privileged boronic acid ester was introduced into the right wing of etravirine (ETR) to obtain a series novel boronate-containing derivatives. These newly synthesized derivatives were evaluated for their anti-HIV potency in MT-4 cells using MTT method, and inhibitory activity HIV-1 reverse transcriptase (RT) assayed by ELISA method. Most compounds displayed promising antiviral against wild-type wide range mutant strains. particular, 4a exhibited most potent panel single...
Thromboxane (TX) A2 has been identified as an important intrahepatic vasoconstrictor upon Kupffer cell (KC) activation during infections such spontaneous bacterial peritonitis (SBP). The study aimed to investigate the role of TLRs in TXA2 increase liver nonparenchymal cells and their related mechanisms. Here, we TLR-2 a common pathway for different microbials: microbial lysates including Gram-positive bacteria, Gram-negative fungi all increased secretion via human KCs, accompanied by...
BACKGROUND Some patients with the novel 2019 coronavirus disease (COVID-19) display elevated liver enzymes antiviral drugs that can be used against COVID-19 are associated a risk of hepatotoxicity AIM To analyze clinical significance dynamic monitoring function METHODS This was retrospective study diagnosed in January and February 2020 at Department Infection, Shantou Central Hospital The exclusion criteria for all were: (1) History chronic disease;(2) kidney disease;(3) coronary heart...
Abstract Background/Objectives : The aim of this study is to explore the relationship between length hospital stay and mean corpuscular hemoglobin (MCH) in acute pancreatitis (AP) patients. Methods included 273 AP patients without coronary heart disease, diabetes, hypertension, tumor, psychosis anemia. clinical data was collected from electronic medical records. Results We separated all into three groups according stay. observed that gender (P=0.017) severity classification (P=0.000) were...
Abstract The emergence of the novel human coronavirus SARS-CoV-2 has caused a worldwide epidemic disease 2019 (COVID-19), which markedly affected global health and economy. Both uncontrolled viral replication proinflammatory cytokine storm can cause severe tissue damage in COVID-19 patients. utilizes angiotensin-converting enzyme 2 (ACE2) as its entry receptor. In this study, we generated ACE2 extracellular domain-Fc scFv-IL6R-Fc fusion protein to differentially neutralize virus temper...
Abstract Purpose Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor with a bad outcome. Leptomeningeal disease (LMD) severe complication of GBM, worse outcome have no effective treatment. A combination chemotherapy was conducted to evaluated GBM patients LMD. Methods retrospective analysis diagnosed LMD between January 2012 December 2019 in our institution. All these accepted at least one cycle therapy intrathecal methotrexate(MTX) systemic chemotherapy....