A5063766440- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Pancreatitis Pathology and Treatment
- Glycosylation and Glycoproteins Research
- Cancer-related molecular mechanisms research
- Mycobacterium research and diagnosis
- Calpain Protease Function and Regulation
- Cancer Genomics and Diagnostics
- Immunotherapy and Immune Responses
- Cancer-related Molecular Pathways
- Liver Disease and Transplantation
- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cancer Cells and Metastasis
- Cancer Mechanisms and Therapy
- Drug-Induced Hepatotoxicity and Protection
- Galectins and Cancer Biology
- Colorectal Cancer Surgical Treatments
- Heat shock proteins research
- Viral-associated cancers and disorders
- Hereditary Neurological Disorders
- RNA Interference and Gene Delivery
- Inflammation biomarkers and pathways
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2014-2024
Wenzhou Medical University
2014-2024
Wenzhou Central Hospital
2016
University Gastroenterology
2016
Andrographolide (ADH), a diterpenoid lactone extracted from Andrographis paniculata, has been found to have anti-inflammatory and anti-oxidative effects. However, its protective effects mechanisms on liver injury not investigated clearly. This study takes an attempt reveal the mechanism of ADH lipopolysaccharide (LPS) D-galactosamine (D-GalN)-induced acute in mice. The mice model was induced by LPS (60 mg/kg) D-GalN (800 mg/kg), given 1 h after treatment. Hepatic tissue histology measured...
Abstract Background The non-HDL-cholesterol to HDL-cholesterol (NHDLC/HDLC) ratio is closely related a variety of dyslipidemia-related diseases. This study examined the relationship between NHDLC/HDLC and non-alcoholic fatty liver (NAFLD) in children adolescents. Methods cross-sectional survey included total 7759 eligible Chinese adolescents (5692 boys 2067 girls) who received routine medical examinations. anthropometric laboratory data subjects were collected. NAFLD was diagnosed by...
Aim: miRNAs have been recognized for their potential in cancer therapeutics, and multiple were suggested to affect target genes expression. To overcome limitations of free synthetic miRNAs, such as easily degraded biofluids limited cellular uptake, novel delivery systems need be developed. Materials & methods: Using surface-functionalizing technique, poly(D,L-lactide-co-glycolide)/poly(L-lactide)-block-poly(ethylene glycol)-folate polymer nanoparticle (PLGA/PLA-PEG-FA) loaded with miR-204-5p...
BACKGROUND Lymph node metastasis and tumor progression depend on lymphovascular invasion (LVI). This study aimed to investigate the prognostic role of LVI in patients with stage III colorectal cancer (CRC) develop a nomogram. MATERIAL AND METHODS A retrospective included 437 CRC. The impact overall survival (OS) was analyzed Kaplan-Meier method Cox regression model. nomogram constructed, its predictive accuracy evaluated using concordance index (C-index) calibration plot. RESULTS found 19.7%...
Neoantigens play a crucial role in cancer immunotherapy. However, the effectiveness and safety of neoantigen-based immunotherapies patients with colorectal (CRC), particularly Chinese population, have not been well studied. This study explored feasibility neoantigens treatment CRC. Whole-exome sequencing (WES) transcriptome were used to identify somatic mutations, RNA expression, human leukocyte antigen (HLA) alleles. Neoantigen candidates predicted, immunogenicity was assessed. The...
Background and Aims: Acute liver injury (ALI) is a clinical syndrome characterized by rapid loss of function, which may progress to life-threatening failure. We conducted this meta-analysis examine the evidence on effects probiotics or prebiotics ALI. Methods Results: Several databases, including PubMed, EMBASE, Cochrane Library, were scrutinized from inception through February 2021 combining key search terms, yielding 26 eligible studies, concluded that modulation gut microbiota...
AIM:To assess human cytomegalovirus-encoded US28 gene function in colorectal cancer (CRC) pathogenesis.METHODS: Immunohistochemical analysis was performed to determine expression 103 CRC patient samples and 98 corresponding adjacent noncancerous samples.Patient data were compared by age, sex, tumor location, histological grade, Dukes' stage, overall mean survival time.In addition, the
Some studies have demonstrated that Rab11-family interacting proteins (Rab11-FIPs) are connected with the tumorigenesis, and they may act as tumor promoters in some cancers. The clinicopathological significance of protein 4 (Rab11-FIP4 ) expression its possible effects on pancreatic cancer (PC) still undiscovered. In this study, Rab11-FIP4 level 60 PC specimens pair-matched non-cancerous samples were detected by immunohistochemistry analysis. results analysed compared each patients' clinical...
As a therapeutic target for cancer treatment, HSP90 has been explored extensively. However, the significant side effects of inhibitor 17AAG have limited its clinical use.In this study, we used hyaluronic acid (HA)-decorated DOTAP-PLGA hybrid nanoparticles (HA-DOTAP-PLGA NPs) as 17AAG-delivery carriers targeted colon therapy.Different methods were to characterize successful fabrication these PLGA NPs. Our results demonstrated that internalization HA-NPs in cells was governed by...
Recent studies suggest that latexin (Lxn) expression is involved in stem cell regulation and it plays significant roles tumor migration invasion. The clinicopathological significance of Lxn its possible correlation with CD133 pancreatic ductal adenocarcinoma (PDAC) currently unknown. In the present study, immunohistochemical analysis was performed to determine 43 PDAC patient samples 32 corresponding adjacent non-cancerous samples. results were analyzed compared age, gender, site size,...
An increasing number of evidence suggests that pancreatic cancer contains stem cells (CSCs), which may be relevant to the resistance chemotherapy. Latexin (Lxn) is a negative regulator cell proliferation and we investigate effects Lxn on CD133+ stem-like cells. miapaca-2 cells, human carcinoma line, were isolated sorted by magnetic activated sorting flow cytometry. The capacity for self-renewal, proliferation, tumorigenicity was determined floating spheres test tumor xenograft assays....
Abstract Dietary n -3 PUFA may have potential benefits in preventing peptic ulcer disease (PUD). However, data from observational epidemiological studies are limited. Thus, we conducted a Mendelian randomisation analysis to reveal the causal impact of on PUD. Genetic variants strongly associated with plasma levels total or individual including plant-derived α-linolenic acid and marine-derived EPA, DPA DHA were enrolled as instrumental variables. Effect size estimates PUFA-associated genetic...
Abstract Background : The non-HDL cholesterol to HDL (NHDLC/HDLC) ratio is closely related a variety of dyslipidemia-related disease. This study aimed inspect the relationship between NHDLC/HDLC and non-alcoholic fatty liver (NAFLD) in childhood adolescence. Methods In this cross-sectional survey, total 7,759 eligible Chinese children adolescents (5,692 boys 2,067 girls) were received routine medical examinations. anthropometric laboratory data subjects collected. NAFLD was diagnosed by...
Objective To investigate the relationship between gene polymorphisms of T cell immunoglobulin domain and mucin protein-3 (Tim-3) ulcerative colitis (UC) in Han nationality Zhejiang. Methods A total 391 UC patients 573 healthy controls were recruited. Two single nucleotide (SPNs) Tim-3 (rs1036199 rs10515746) examined by improved multiple ligase detection reaction technique. Chi-square test or Fisher′s exact was performed to analyze differences distribution its influence on location...
Abstract Background : The non-HDL-cholesterol to HDL-cholesterol (NHDLC/HDLC) ratio is closely related a variety of dyslipidemia-related diseases. This study aimed inspect the relationship between NHDLC/HDLC and non-alcoholic fatty liver (NAFLD) in children adolescents. Methods In this cross-sectional survey, total 7,759 eligible Chinese adolescents (5,692 boys 2,067 girls) received routine medical examinations. anthropometric laboratory data subjects were collected. NAFLD was diagnosed by...
Gastric cancer (GC) remains the fourth-leading malignancy worldwide and has a high mortality rate. Accumulating evidence reveals that long noncoding RNAs (lncRNAs) play essential roles in tumorigenesis metastasis can be used as potential biomarkers for diagnosis prognosis.We downloaded gene expression profiles from National Center of Biotechnology Information Gene Expression Omnibus (GEO), screened lncRNAs differentially expressed gastric tissues adjacent tissues, then constructed...
Objective To observe the effect of Latexin treatment on chemoresistance in gemcitabine-resistant pancreatic cancer cell line SW1990, and explore potential mechanism. Methods Gemcitabine-resistant SWl990/GZ was induced established by increasing gemcitabine dosage intermittently. IC50 SW1990 cells pre post at 10, 20 40 ng/μl for 48 h evaluated using CCK-8 assay. The mRNA protein expression gene SW1990/GZ were qRT-PCR Western blot, Shh Gli1 treated h. Results A obtained...