A5016499063- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Diversity and Career in Medicine
- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Impairment Studies
- Neuroscience and Neuropharmacology Research
- Ophthalmology and Eye Disorders
- Corneal surgery and disorders
- Surgical Simulation and Training
- Innovations in Medical Education
- Dental Education, Practice, Research
- Retinal Diseases and Treatments
- Visual perception and processing mechanisms
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Cerebral Venous Sinus Thrombosis
- Ophthalmology and Visual Health Research
- Retinal Imaging and Analysis
- Cellular transport and secretion
- Inflammasome and immune disorders
- Ocular Surface and Contact Lens
- Metabolism and Genetic Disorders
- Axon Guidance and Neuronal Signaling
- Ubiquitin and proteasome pathways
University of Minnesota
2021-2024
University of Minnesota Medical Center
2021-2023
Washington University in St. Louis
2002-2021
Twin Cities Orthopedics
2021
Jewish Hospital
2019
Barnes-Jewish Hospital
2019
King Abdulaziz University
2018
Christie's
2015
Solvay (Belgium)
2015
Research to Prevent Blindness
2015
Quantitative fluorescence imaging was used to study the regulation of acetylcholine receptor (AChR) number and density at neuromuscular junctions in living adult mice. At fully functional synapses, AChRs have a half-life about 14 days. However, 2 hours after neurotransmission blocked, now less than day; rate 25 times faster before. Most lost receptors were not quickly replaced. Direct muscle stimulation or restoration synaptic transmission inhibited this process. that removed from...
Although almost equal numbers of male and female medical students enter into ophthalmology residency programs, whether they have similar surgical experiences during training is unclear.To determine differences for cataract surgery total procedural volume between residents residency.This retrospective, longitudinal analysis resident case logs from 24 US programs spanned July 2005 to June 2017. A 1271 were included. Data analyzed August 12, 2017, through April 4, 2018.Variables included mean...
Spontaneous activity is thought to regulate synaptogenesis in many parts of the developing nervous system. In vivo evidence for this regulation, however, scarce and comes almost exclusively from experiments which normal was reduced or blocked completely. Thus, whether spontaneous itself promotes plays a purely permissive role remains uncertain. addition, how influences synapse dynamics shape connectivity its effects among neurons are uniform cell-type-dependent unclear. mice lacking cone–rod...
Inherited cataract is a clinically important and genetically heterogeneous cause of visual impairment. Typically, it presents at an early age with or without other ocular/systemic signs lacks clear phenotype-genotype correlation rendering both clinical classification molecular diagnosis challenging. Here we have utilized trio-based whole exome sequencing to discover mutations in candidate genes underlying autosomal dominant segregating three nuclear families. In family A, identified...
Nerve terminal withdrawal is accompanied by a loss of acetylcholine receptors (AChRs) at corresponding postsynaptic sites during the process synapse elimination developing () and reinnervated adult neuromuscular junctions. Aside from AChR nerve loss, however, molecular cellular alterations that occur are unknown. To gain better understanding cascade events leads to disassembly synaptic process, we surveyed distribution elements specialization, basal lamina, supporting Schwann cells occurs...
Abstract As the field of ophthalmology has evolved in last several decades, so gender distribution ophthalmologists. We conducted a narrative review to further characterise status women realm publication, presentations, editorial positions, grants, academic promotion, and financial compensation. While proportion publishing, presenting, filling roles increased over time, it still does not match that men. Women are more likely be first authors instead senior authors, have lower average...
Purpose: Among the options for surgical management of pediatric glaucoma, destruction ciliary body reduces aqueous production and, consequently, intraocular pressure (IOP). Compared to more invasive filtering and shunt procedures, cyclodestruction is an attractive option control IOP in glaucomas. Methods: The relative reduction IOP, duration effect, comparable safety efficacy transscleral cyclophotocoagulation (TSCP) endoscopic (ECP) patients with glaucoma was studied this retrospective...
The treatment of anisometropic or ametropic amblyopia has traditionally enjoyed a high success rate. Early initiation and consistent use spectacle correction can completely resolve in majority patients. For those with that fail to improve glasses wear alone, patching atropine penalisation lead equalisation visual acuity. However, successful requires full-time compliance refractive this be challenge for patient population often one eye good acuity without correction. Other barriers select...
To report a case of recurrent nummular keratitis in pediatric patient with Hyperimmunoglobulinemia D syndrome.A retrospective chart review.A 14-year-old boy syndrome (HIDS) presented photophobia and ocular irritation concomitant disease exacerbation. He was found on exam to have significant keratitis, which responded short course topical steroids. Despite acute response local immunosuppression, the had several attacks eventually developed large corneal scar decreased vision. After initiation...
Biologic agents have dramatically shifted the treatment paradigm for rheumatic disease. Use of these can decrease disease burden, allow patient to be weaned from corticosteroids, and reduce likelihood relapse. Eye associated with conditions may present a wide range signs symptoms. This coexisting pathology should not overlooked considered reason initiation or continuation biologic therapy. Additionally, many ocular manifestations respond preferentially specific targeting molecules. paper...
Brown-Vialetto-Van Laere syndrome (BVVL) is a rare, progressive neurodegenerative disease with fewer than 100 cases reported in the literature. It characterized by pontobulbar palsy and sensorineural hearing loss.1 The age at onset varies from infancy to early adulthood, commonly presenting cranial nerve VII–XII palsies deafness. Other findings include gait ataxia, limb weakness, optic atrophy, epilepsy, respiratory compromise.1 genetic etiology of BVVL has recently been linked mutations...
To test whether crowdsourced lay raters can accurately assess cataract surgical skills. Two-armed study: independent cross-sectional and longitudinal cohorts. Washington University Department of Ophthalmology. Sixteen surgeons with varying experience levels submitted surgery videos to be graded by 5 experts 300+ crowdworkers masked surgeon experience. Cross-sectional 50 from ranging first-year resident attending physician, pooled years training. Longitudinal 28 obtained at regular intervals...
The purpose of this study was to describe two challenging cases septic cavernous sinus thrombosis (CST), which presented with vastly different clinical signs and symptoms.We present CST markedly differing presentations, medical comorbidities, degree impairment. Initial imaging each patient failed show thromboembolic disease.Both patients required multiple procedures arrive at the correct diagnosis. Each child did respond treatment once diagnosis made.CST can have a highly variable...
Abstract Precise targeting of retinal projections is required for the normal development topographic maps in mammalian primary visual system. During development, axons project to and occupy topographically appropriate positions dorsal lateral geniculate nucleus (dLGN) superior colliculus (SC). Phr1 mutant mice, which display mislocalization ipsilateral retinogeniculate projection independent activity ephrin-A signaling, were found have a more global disruption specificity retinofugal inputs....
To compare visual acuity outcomes and loss to follow-up after initiation of treatment for unilateral amblyopia in children from different socioeconomic backgrounds.Medical records diagnosed as having at an initial encounter between 2015 2018 were reviewed. Medicaid private insurance used proxies status (SES). Data points collected the patients' initial, follow-up, final visits. Visual improvement was primary outcome variable patients with least one appointment. In a separate analysis,...
Abstract: Scleral infantile hemangiomas are rare. We describe a patient who presented at 3 months of age with an enlarging hemangioma on the sclera left eye. He had two other eyebrow and chest. Treatment propranolol resulted in marked improvement all his hemangiomas. did not develop any ocular complications.