A5058712943- Cancer-related gene regulation
- RNA modifications and cancer
- Congenital heart defects research
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Chinese history and philosophy
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Generational Differences and Trends
- CRISPR and Genetic Engineering
- Circular RNAs in diseases
- Heat shock proteins research
- Cultural Differences and Values
- Hemophilia Treatment and Research
- Genetic Associations and Epidemiology
- International Student and Expatriate Challenges
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiomyopathy and Myosin Studies
- Blood Coagulation and Thrombosis Mechanisms
- Ferroptosis and cancer prognosis
- Yersinia bacterium, plague, ectoparasites research
- Connexins and lens biology
- Cancer-related Molecular Pathways
- China's Ethnic Minorities and Relations
- Educational Reforms and Innovations
Shaoguan University
2022
Zhongnan Hospital of Wuhan University
2016-2019
Wuhan University
2014-2019
Alterations in DNA methylation are demonstrated atherosclerosis pathogenesis. However, changing rules of global and hydroxymethylation peripheral blood leukocytes (PBLs) different cell subtypes coronary artery disease (CAD) patients still inconclusive, much less is known about mechanisms underlying. We recruited 265 CAD 270 healthy controls with genomic from PBLs, which 50 were randomly chosen isolated neutrophils, lymphocytes monocytes, RNA PBLs. Genomic 5-methylcytosine (5-mC)...
Apolipoprotein E (ApoE) plays an important role in lipid metabolism and clearance. Statins are the most common drugs used to modulate profile clinic therapy; associations between ApoE polymorphisms statin response lipids were inconsistent previous studies among different ethnicities. Our study aimed demonstrate relationships statins gene lifestyle risk factors Chinese arteriosclerotic cardiovascular disease (ASCVD) patients with dyslipidemia.A total of 1002 dyslipidemia ASCVD recruited this...
Protein phosphatase 2 regulatory subunit B, alpha (PPP2R3A), a of protein 2A (PP2A), is major serine/threonine that regulates crucial function in development and growth. Previous research has implied PPP2R3A was involved heart failure, PR130, the largest transcription PPP2R3A, functioning calcium release sarcoplasmic reticulum (SR), plays an important role excitation-contraction (EC) coupling. To obtain better understanding PR130 functions myocardium cardiac development, two pr130-deletion...
The alpha regulator subunit B'' of protein phosphatase 2 (PPP2R3A), a regulatory 2A (PP2A), was reported to present special subcellular localization in cardiomyocytes and elevate non-ischemia failing hearts. PPP2R3A has two transcriptions PR72 PR130. acts as negative the Wnt signaling cascade, while cascade plays pivotal role cardiac development. And PR130 found be involved development zebrafish our previous study. Thus, investigate function heart, stable pr72 knockout (KO) lines were...
Recently, a significant epigenetic component in the pathogenesis of Coronary Artery Disease (CAD) has been realized. Here, we evaluated possible association candidate Single Nucleotide Polymorphisms (SNPs) epigenetic-regulatory gene, DNA methyltransferase 1 (DNMT1), with CAD Chinese Han population. Five tag SNPs (rs16999593, rs2336691, rs2228611, rs4804494, rs7253062) were analyzed by High Resolution Melt (HRM) method 476 patients and 478 controls. Overall, there differences genotype allele...
Hemophilia A (HA) is the most common inherited X‑linked recessive bleeding disorder caused by heterogeneous mutations in factor VIII gene (FVIII). Diagnosis of carrier critical for preventing birth children affected this coagulation disorder, which ultimately facilitates its management. Due to nature mutations, large inversions and complexity FVIII gene, direct recognition disease‑associated mutation HA complex. Indirect linkage analysis using highly informative heterozygous polymorphic...
Background: Atorvastatin belongs to the group of statins and is leading drug for hypercholesterolemia treatment. Although, its anticancer effects are highly appreciated, properties still unclear. The aim this study was explore underlying mechanisms induced by atorvastatin enlarge potential target in non-small cell lung cancer. Methods: arget genes were collected DrugBank database. Prediction interaction between primary targets secondary performed, protein-protein network constructed though...
Culture has largely benefited from the invention and use of Internet. With change society lifestyle, culture with its characteristics created by Chinese peoples, especially traditional some ethnic groups, gradually disappeared, emergence Internet Things exacerbated phenomenon cultural disappearance. This study investigates inheritance concepts Yao junior high school students in context through a questionnaire survey Han six dimensions: quality, family environment, history, activities,...