A5051134401- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Pediatric Hepatobiliary Diseases and Treatments
- Nutrition and Health in Aging
- DNA Repair Mechanisms
- Retinal Development and Disorders
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Retinal Diseases and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Chromatography in Natural Products
- Body Composition Measurement Techniques
- Airway Management and Intubation Techniques
- Endoplasmic Reticulum Stress and Disease
- Traditional Chinese Medicine Analysis
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
- Diabetes Treatment and Management
- interferon and immune responses
- Tracheal and airway disorders
Sichuan University
2014-2025
West China Hospital of Sichuan University
2014-2025
Xiangyang Central Hospital
2024
University of South China
2021-2024
Guangxi Medical University
2013-2024
Shanghai University of Sport
2024
North Sichuan Medical University
2024
China XD Group (China)
2024
Hubei University of Arts and Science
2024
West China Medical Center of Sichuan University
2020-2023
The geometry of retinal layers is an important imaging feature for the diagnosis some ophthalmic diseases. In recent years, layer segmentation methods optical coherence tomography (OCT) images have emerged one after another, and huge progress has been achieved. However, challenges due to interference factors such as noise, blurring, fundus effusion, tissue artifacts remain in existing methods, primarily manifesting intra-layer false positives inter-layer boundary deviation. To solve these...
To evaluate the diagnostic value of ultrasound radiomics in distinguishing between benign and malignant breast nodules women who have undergone silicone augmentation. A retrospective study was conducted 99 detected by 93 had The data were collected 1 January 2006 September 2023. allocated into a training set (n = 69) validation 30). Regions interest (ROIs) manually delineated using 3D Slicer software, radiomic features extracted selected Python programming. Eight machine learning algorithms...
Diabetes-induced visual dysfunction is associated with significant neuroretinal cell death. The current study was designed to investigate the role of Protein Regulated in Development and DNA Damage Response 1 (REDD1) diabetes-induced retinal death dysfunction. We recently demonstrated that REDD1 protein expression elevated response hyperglycemia retina diabetic rodents. an important regulator Akt mammalian target rapamycin as such plays a key neuronal function survival. In R28 cells culture,...
Cullin4B (CUL4B) is a scaffold protein of the CUL4B-Ring E3 ligase (CRL4B) complex. However, role CUL4B in development breast cancer remains poorly understood. Here it shown that CRL4B interacts with multiple histone deacetylase (HDAC)-containing corepressor complexes, including MTA1/NuRD, SIN3A, CoREST, and NcoR/SMRT complexes. It demonstrated CRL4B/NuRD(MTA1) complexes cooccupy E-cadherin AXIN2 promoters, could be recruited by transcription factors Snail ZEB2 to promote cell invasion...
In December 2016, the Union for International Cancer Control (UICC) published 8th edition of Tumor-Node-Metastasis (TNM) classification malignant tumors, including a number vital changes in definitions T2 category, N category and stages gallbladder cancer (GBC). The clinical value this newly updated patients with surgically treated GBC has not been rigorously validated. present study aimed to analyze prognosis high-volume surgical unit, validate prognostic new UICC TNM classification,...
PURPOSE.The translational repressor 4E-BP1 interacts with the mRNA cap-binding protein eIF4E and thereby promotes cap-independent translation of mRNAs encoding proteins that contribute to diabetic retinopathy.Interaction is enhanced in retina rodents, at least part, as a result elevated expression.In present study, we examined role diabetes-induced visual dysfunction, well mechanism whereby hyperglycemia expression.METHODS.Nondiabetic wild-type 4E-BP1/2 knockout mice were evaluated for...
The Clavien‑Dindo (C‑D) classification is a simple and feasible grading system of postoperative complications. aim the present study was to apply this retrospectively classify all types post‑pancreaticoduodenectomy (PD) complications (PPCs) systematically identify associated risk factors. Between January 2009 December 2014, C‑D applied PPCs for 1,056 patients who had undergone PD at West China Hospital. Univariate multivariate analyses were performed link perioperative parameters mortality...
Abstract: This study aimed to determine the protective effects of tetrandrine (Tet) on murine ischemia-injured retinal ganglion cells (RGCs). For this, we used serum deprivation cell model, glutamate and hydrogen peroxide (H 2 O )-induced RGC-5 death models, staurosporine-differentiated neuron-like in vitro. We also investigated survival purified primary-cultured RGCs treated with Tet. An vivo ischemia/reperfusion model was examine RGC after Tet administration 1 day before ischemia. found...
Background: In clinical practice, the species of Atractylodes are difficult to identify based on their morphological and chemical features which often leads confusion. addition, composition volatile components may influence efficacy rhizomes Atractylodes. Materials Methods: this study, a comprehensive two-dimensional gas chromatography with mass spectrometry coupled multivariate data analysis was employed investigate differences in three Atractylodes, namely lancea (Thunb.) DC, japonica...
Background Hippocampal sclerosis (HS) is the most common pathological type of temporal lobe epilepsy (TLE) and one important surgical markers. Currently, HS mainly diagnosed manually by radiologists based on visual inspection MRI, which greatly relies MRI quality physician experience. In clinical practice, non-thin scans are often used due to time efficiency needed for acquisition. However, these can be difficult junior physicians interpret accurately. Thus, rapid accurate diagnosis using...
Warm ischemia/reperfusion (I/R) is a common clinical problem during liver transplantation and resection. ischemia also occurs trauma shock. However, there still no safe promising strategy for protecting the from I/R injury. Signal transducer activator of transcription 3 (STAT3) major immediate response molecule cell survival. In this study, we first confirmed that pharmacological STAT3 inhibitor, (E)-2-cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide (AG490), significantly reduced...