A5101991043- Tea Polyphenols and Effects
- melanin and skin pigmentation
- Phytochemicals and Antioxidant Activities
- Biochemical Analysis and Sensing Techniques
- Adipose Tissue and Metabolism
- Distributed and Parallel Computing Systems
- Food Quality and Safety Studies
- Demographic Trends and Gender Preferences
- Nicotinic Acetylcholine Receptors Study
- Cancer-related Molecular Pathways
- Enzyme-mediated dye degradation
- Diabetes and associated disorders
- Environmental and Agricultural Sciences
- Innovative Educational Techniques
- GDF15 and Related Biomarkers
- Synthesis and Properties of Aromatic Compounds
- Porphyrin and Phthalocyanine Chemistry
- Cell death mechanisms and regulation
- bioluminescence and chemiluminescence research
- Cardiac Fibrosis and Remodeling
- Melanoma and MAPK Pathways
- Microbial Metabolites in Food Biotechnology
- Advanced Sensor and Control Systems
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Exercise and Physiological Responses
Xiamen University
2007-2024
Xiangtan University
2014
Beijing Health Vocational College
2012
Sun Yat-sen University
2011
Feng Chia University
2003
Tianshui Normal University
2002
Tyrosinase (EC 1.14.18.1) is a key enzyme in pigment biosynthesis of organisms. trans-Cinnamaldehyde thiosemicarbazone, derivative benzaldehyde was synthesized as an inhibitor tyrosinase. The inhibitory effects this compound on the activity mushroom tyrosinase were investigated. results showed that trans-cinnamaldehyde thiosemicarbazone could potently inhibit both monophenolase and diphenolase For activity, not only lengthen lag time but also decrease steady-state rate. IC50 value determined...
In the process of longan production and processing, a large amount remnants is produced, such as dried pericarps seeds, which have been reported to be rich in polyphenols but not effectively utilized. this paper, total phenolic contents seeds were found 39.58 ± 3.54 69.53 1.99 mg/g (DW), respectively, accounting for 60–80% those fresh samples. The extractable condensed tannins (ECTs) 19.25 6.71 (DW) 44.59 2.05 60–70% These data indicate that sampled retained. antioxidant capacity ECTs from...
Abnormal melanogenesis can lead to hyperpigmentation. Tyrosinase (TYR), a key rate-limiting enzyme in melanin production, is an important therapeutic target for these disorders. We investigated the TYR inhibitory activity of hydrolysates extracted from muscle tissue Takifugu flavidus (TFMH). used computer-aided virtual screening identify novel peptide that potently inhibited synthesis, simulated its binding mode TYR, and evaluated functional efficacy vitro vivo. TFMH diphenolase activities...
The dramatic increase in obesity is putting people under increasing pressure. Lipase inhibitors, as a kind of effective anti-obesity drug, have attracted more and researchers' attention recent years because their advantages acting on the intestinal tract having no side effects central nervous system. In this study, lipase inhibitor Fu Brick Theophylline (FBT) was screened based enzyme molecular dynamics, inhibition mechanism inhibitors analyzed discussed at cellular level animal model level....
Melanoma, one of the most lethal forms skin cancer, has potential to develop in any area where melanocytes are present. Currently, postoperative recurrence due emergence systemic drug resistance represents a significant challenge treatment melanoma. In this study, terphenyllin (TER), distinctive inhibitory impact on melanoma cells was identified from natural p-terphenyl metabolite. This study aimed elucidate intrinsic mechanism effect, which may facilitate discovery novel chemotherapeutic...
Rigor mortis occurs when muscle extension vanishes through the irresistible coupling of actin and myosin by consumption adenosine triphosphate as energy. To clarify cause differences in progression rigor mortis, seven fish species were used samples. The superprecipitation reaction Mg2+ -ATPase activity actomyosin dorsal ordinary measured, slope regression line between these two variables was calculated for each specimen. fiber types sample discriminated stability ATPase at acid alkaline...
<title>Abstract</title> Melanoma, the deadliest form of skin cancer, can develop in any area where melanocytes are present. Currently, platinum-based chemotherapeutic drugs such as cisplatin commonly used for anti-tumor treatment. However, these often result significant cytotoxicity, highlighting need more effective and less toxic alternatives. Terphenyllin (TER) is a natural compound derived from coral fungus <italic>Aspergillus candidus</italic>. Our results demonstrated that TER notably...
Melanin overproduction leads to pigmented skin diseases. Brown algae polyphenols, non-toxic secondary metabolites, exhibit potential bioactivities.
Cholangiocarcinoma is a malignant tumor that emerges in the intrahepatic or extrahepatic bile ducts. Doramectin (DOR), third-generation derivative of avermectins (AVMs), renowned for its low toxicity and high efficiency. However, no research has hitherto focused on anti-cholangiocarcinoma effects these drugs. In this study, we undertook preliminary exploration mechanism through which DOR inhibits viability human cholangiocarcinoma cells (Mz-ChA-1) via transcriptome analysis molecular...
This paper describes systemically a theoretical research on the interaction of alkali-metal cations ( Li + , Na K and Rb ) with five different crown ether derivatized thiophenes using density functional theory (DFT). The fully optimized geometries have been performed real frequencies which indicate minima states. structures electronic properties, such as HOMO LUMO energies, bandgaps free ligands L (L 1 -L 5 ), complexes L/M at B3LYP/6-31+G(d,p) Lanl2DZ level. Natural bond orbital (NBO)...
Pufferfish is increasingly regarded by many as a delicacy. However, the tetrodotoxin (TTX) that accumulates in its body can be lethal upon consumption humans. TTX known to mainly accumulate pufferfish skin, but accumulation mechanisms are poorly understood. In this study, we aimed explore possible mechanism of skin Takifugu flavidus following treatment with TTX. Through liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis, detected 37.3% toxin accumulated at end rearing period...