A5066383724- Dementia and Cognitive Impairment Research
- Geriatric Care and Nursing Homes
- Genetic Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Health disparities and outcomes
- Intergenerational Family Dynamics and Caregiving
- Palliative Care and End-of-Life Issues
- Interpreting and Communication in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
- Diet and metabolism studies
- Mental Health and Psychiatry
- Mental Health and Patient Involvement
- Physical Activity and Health
- Mitochondrial Function and Pathology
- Neurological disorders and treatments
- Psychiatric care and mental health services
- Schizophrenia research and treatment
- Aging and Gerontology Research
- Amyotrophic Lateral Sclerosis Research
- Frailty in Older Adults
- Health, Environment, Cognitive Aging
- Health Policy Implementation Science
- Interprofessional Education and Collaboration
- Stroke Rehabilitation and Recovery
- Telemedicine and Telehealth Implementation
The University of Melbourne
2015-2024
National Ageing Research Institute
2017-2024
The Royal Melbourne Hospital
2013-2024
Melbourne Health
2017-2024
Edith Cowan University
2024
Australian e-Health Research Centre
2022
Florey Institute of Neuroscience and Mental Health
2020-2022
Emory University
2021
Mayo Clinic
2021
WinnMed
2021
Currently, over 300 languages are spoken in Australian homes. People without proficient English from non-English speaking countries may not receive equitable care if their health workers do speak primary language. Use of professional interpreters is considered the gold standard; however, for a variety reasons, it often limited to key aspects such as diagnosis and consent. With emergence mobile technologies, increasingly using digital translation tools fill this gap. However, many these...
Abstract Introduction Many patients with cognitive and neuropsychiatric symptoms face diagnostic delay misdiagnosis. We investigated whether cerebrospinal fluid (CSF) neurofilament light (NfL) total‐tau (t‐tau) could assist in the clinical scenario of differentiating neurodegenerative (ND) from psychiatric disorders (PSY), rapidly progressive disorders. Methods Biomarkers were examined specialist services (ND PSY) a national Creutzfeldt‐Jakob registry (Creutzfeldt‐Jakob disease [CJD]...
Importance Interventions that substantially slow neurodegeneration are needed to address the growing burden of Alzheimer disease (AD) societies worldwide. Elevated brain iron observed in AD has been associated with accelerated cognitive decline and may be a tractable drug target. Objective To investigate whether brain-permeable chelator deferiprone slows people AD. Design, Setting, Participants This phase 2, double-masked, placebo-controlled randomized clinical trial 12-month duration was...
ABSTRACT Objectives: While early diagnosis of younger-onset dementia (YOD) is crucial in terms accessing appropriate services and future planning, diagnostic delays are common. This study aims to identify predictors delay a large sample people with YOD investigate the impact specialist service on this time diagnosis. Design: A retrospective cross-sectional study. Setting: The inpatient unit tertiary neuropsychiatry metropolitan Victoria, Australia. Participants: People diagnosed YOD....
Global population ageing has meant a rapid increase in the numbers of older people with dementia, most whom live their own homes. Staying at home is an important determinant health and well-being. As care needs increase, quality community support which receive directly influences capacity to remain While many are supported informally by family carers, formal provided workers often enables them for longer period. However, providing community-based dementia can be challenging. Workers lack...
To understand the attitudes and perceptions of older people with limited English proficiency (LEP) healthcare workers to using mobile translation technology for overcoming language barriers in setting.Australia's cohort aged 65 over has a sizeable population LEP. In settings, difficulties communication may potentially result inadequate care. Mobile applications have been identified as potential way improve between patients staff when used an adjunct professional interpreters low-risk...
Abstract Objectives Younger‐onset dementia (YOD) refers to a where symptom onset occurs when the patient is less than 65 years of age. YOD far common late‐onset (occurring patients are over old) and more challenging diagnose due its heterogeneous presentation. There have been relatively few studies describing demographic diagnostic characteristics with in community, particularly follow‐up information. Methods A retrospective cohort study was performed inpatients admitted tertiary...
Tau deposition in the mesial temporal lobe (MTL) absence of amyloid-β (Aβ-) occurs with aging. The tau PET tracer 18F-MK6240 has low non-specific background binding so is well suited to exploration early-stage deposition. aim this study was investigate associations between MTL tau, age, hippocampal volume (HV), cognition, and neocortical Aβ- cognitively unimpaired (CU) individuals.One hundred ninety-nine participants (Centiloid < 25) who were CU underwent at age 75 ± 5.2 years. standardized...
Abstract Background Our objective was to explore what people receiving and providing care consider be ‘good’ in-home for living with dementia. Methods We conducted 36 in-depth interviews two focus groups key stakeholders in Australia the first quarter of 2018. Participants included those (4 dementia, 15 family carers) or (9 case managers, 5 service 10 home workers). Qualitative thematic analysis guided by Braun Clarke’s six-step approach. Results Consensus reached across all on five themes...
Undertaking co-design with the end users of services has rapidly evolved as best-practice approach to program design, development and implementation. Increased interest in using participatory dementia care drawn attention need for evidence-informed methods facilitating meaningful involvement people their family carers activities. The aim this paper is describe framework used a specialist training home workers. Promoting Independence Through quality Care at Home successful example methodology...
Background There are limited longitudinal studies on the effects of COVID-19 pandemic mental health and well-being, including imposed restrictions lockdowns. Aims This study investigates how living in a pandemic, related lockdowns restrictions, affected people Australia during first year pandemic. Method A total 875 participated survey from 27 May to 14 December 2020. time period includes dates that span pre-, post-wave 2 Australia, with strict sustained public measures. Linear mixed models...
ABSTRACT Background: Older Chinese people are one of the largest and fastest growing immigrant groups in Western countries. The Geriatric Depression Scale (GDS) Anxiety Inventory (GAI) screening tools that have been specifically designed for older people. This study explored their validity, concurrent reliability, cultural appropriateness detecting depression anxiety symptoms among immigrants living Melbourne, Australia. Methods: A total 87 were recruited from senior groups. Five used,...
Touchscreen technology (TT) is a resource that can improve the quality of life residents with dementia, and care staff, in residential aged facilities (RACF) through person-centered approach. To enable use TTs to engage benefit people dementia RACFs, education needed explore how these devices may be used, what facilitates use, address barriers. We sought provide RACF staff views barriers on using TT their dementia. An educational session was given from three long-term RACFs Melbourne,...
Abstract Aims and objectives To trial three mobile translation apps in the healthcare setting to address language barriers everyday care between staff older people with limited English proficiency (LEP). Design A mixed‐methods exploratory study. Methods two‐month of was conducted across four aged‐care hospital wards. Observed interactions during use were recorded, surveys regarding collected at end trial. Data analysed using descriptive statistics thematic content analysis open‐ended...
Background: In Alzheimer’s disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. Visualizing topography vivo may facilitate clinical trials and practice. Objective: This study aimed to investigate whether patterns that are limited mesial temporal lobe (MTL)/limbic regions, those spare MTL can be visually identified using 18 F-MK6240, these associated with different demographic cognitive profiles. Methods: Tau F-MK6240 PET images 151 amyloid-β...
Aims: This study examines elements of genetic discrimination among an at-risk, clinically undiagnosed Huntington's disease (HD) population. Methods: Sixty at-risk individuals, either positive or negative for the HD mutation, completed a survey regarding their experiences discrimination, adverse and unfair treatment, knowledge about existing laws policies surrounding discrimination. Results: eight percent participants reported feeling "Great benefit" from knowing test results. Reported...