A5031611907- Tryptophan and brain disorders
- Diet and metabolism studies
- Gut microbiota and health
- Stress Responses and Cortisol
- Autophagy in Disease and Therapy
- Antibiotic Resistance in Bacteria
- Diet, Metabolism, and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tuberculosis Research and Epidemiology
- Eicosanoids and Hypertension Pharmacology
- Regulation of Appetite and Obesity
- Advanced Neuroimaging Techniques and Applications
- Escherichia coli research studies
- Circadian rhythm and melatonin
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- RNA modifications and cancer
- Cardiovascular Function and Risk Factors
- Mycobacterium research and diagnosis
- Antibiotics Pharmacokinetics and Efficacy
- Neuroendocrine regulation and behavior
- Immune cells in cancer
- Schizophrenia research and treatment
- Rabies epidemiology and control
- Immune Cell Function and Interaction
Radboud University Medical Center
2018-2021
Radboud University Nijmegen
2018-2021
University Medical Center
2019
Allen Institute for Brain Science
2019
Weizmann Institute of Science
2014-2018
Leiden University
2014
Leiden University Medical Center
2013
Metabolic syndrome, leaky guts, and infection syndrome often accompanies obesity hyperglycemia is associated with a breakdown in the integrity of intestinal barrier increased risk systemic infection. Thaiss et al. found that mice Salmonella analog, Citrobacter rodentium , also exhibited hyperglycemia. Deletion glucose transporter GLUT2 altered sensitivity to chemically induced epithelial permeability protected from pathogen invasion. The authors correlation humans between glycated hemoglobin...
Abstract Background The impact of the gut microbiota on host physiology and behavior has been relatively well established. Whether changes in microbial composition affect brain structure function is largely elusive, however. This important as altered have implicated various neurodevelopmental disorders, like attention-deficit/hyperactivity disorder (ADHD). We hypothesized that persons with without ADHD, when transplanted into mice, would differentially modify and/or structure. investigated...
The obesity epidemic increases the interest to elucidate impact of short-chain fatty acids on metabolism, obesity, and brain. We investigated effects propionic acid (PA) caproic (CA) metabolic risk factors, liver adipose tissue pathology, brain function, structure (by MRI), gene expression, during development in Ldlr−/−.Leiden mice. mice received 16 weeks either a high-fat diet (HFD) induce or chow as reference group. Next, obese HFD-fed were treated 12 with (a) HFD + CA (CA), (b) PA (PA),...
Resistance to ciprofloxacin in Escherichia coli is increasing parallel increased use of fluoroquinolones both The Netherlands and other European countries. objective was investigate the contribution active efflux expression outer membrane proteins (OMPs) a collection clinical E. isolates collected at microbiology department Dutch hospital. Forty-seven wide range minimum inhibitory concentrations known mutations quinolone resistance determining region were included. A fluorometric...
Abstract Exposure to antibiotic treatment has been associated with increased vulnerability various psychiatric disorders. However, a research gap exists in understanding how adolescent therapy affects behavior and cognition. Many antibiotics that target bacterial translation may also affect mitochondrial resulting impaired function. The brain is one of the most metabolically active organs, hence vulnerable We hypothesized exposure during early adolescence would directly function, result...
Abstract Introduction: There is an increasing interest to elucidate the health effects of short-chain fatty acids (SCFAs) on metabolism, obesity and brain function. Obesity often associated with development non-alcoholic steatohepatitis (NASH) cognitive impairment. We herein investigated potential SCFA propionic acid (PA) NASH function including cognition behavior readouts. Materials Methods: During 17 weeks run-in, LDLR-/-.Leiden mice received either high-fat diet (HFD) establish or chow as...