A5001768641- Muscle metabolism and nutrition
- Muscle Physiology and Disorders
- Diet and metabolism studies
- Nutrition and Health in Aging
- Sports Performance and Training
- Exercise and Physiological Responses
- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Agriculture Sustainability and Environmental Impact
- Metabolism and Genetic Disorders
- Consumer Attitudes and Food Labeling
- Muscle activation and electromyography studies
- Nutritional Studies and Diet
- Nutrition, Genetics, and Disease
- Mitochondrial Function and Pathology
- Obesity, Physical Activity, Diet
- Spaceflight effects on biology
- Clinical Nutrition and Gastroenterology
- Biochemical effects in animals
- Gout, Hyperuricemia, Uric Acid
- Body Composition Measurement Techniques
- Liver Disease Diagnosis and Treatment
- Regulation of Appetite and Obesity
- Metabolism, Diabetes, and Cancer
- Thermoregulation and physiological responses
University of Exeter
2015-2025
Fremantle Hospital
2025
Fiona Stanley Hospital
2025
Advisory Board Company (United States)
2024
Heavitree Hospital
2023-2024
In-Q-Tel
2024
Health & Life (Taiwan)
2024
Charles University
2023
Thomayer University Hospital
2023
Quorn (United Kingdom)
2022
Short (<10 days) periods of muscle disuse, often necessary for recovery from illness or injury, lead to various negative health consequences. The current study investigated mechanisms underlying disuse-induced insulin resistance, taking into account atrophy. Ten healthy, young males (age: 23 ± 1 years; BMI: 23.0 0.9 kg · m(-2)) were subjected week strict bed rest. Prior and after rest, lean body mass (dual-energy X-ray absorptiometry) quadriceps cross-sectional area (CSA; computed...
Progressive loss of skeletal muscle mass with aging (sarcopenia) forms a global health concern. It has been suggested that an impaired capacity to increase protein synthesis rates in response intake is key contributor sarcopenia. We assessed whether differences post-absorptive and/or post-prandial exist between large cohorts healthy young and older men.We performed cross-sectional, retrospective study comparing vivo determined stable isotope methodologies 34 (22±1 y) 72 (75±1 men, 35 40...
The impact of disuse on the loss skeletal muscle mass and strength has been well documented. Given that most studies have investigated atrophy after more than 2 weeks disuse, few data are available shorter periods disuse. We assessed 5 14 days mass, associated intramuscular molecular signalling responses.Twenty-four healthy, young (23 ± 1 year) males were subjected to either (n = 12) or one-legged knee immobilization using a full leg cast. Before immediately period, quadriceps...
Abstract Aim Short periods of muscle disuse, due to illness or injury, result in substantial skeletal atrophy. Recently, we have shown that a single session neuromuscular electrical stimulation ( NMES ) increases protein synthesis rates. The aim was investigate the capacity for daily attenuate atrophy during short‐term disuse. Methods Twenty‐four healthy, young (23 ± 1 year) males participated present study. Volunteers were subjected 5 days one‐legged knee immobilization with ; n = 12)...
Football is a global game which constantly evolving, showing substantial increases in physical and technical demands. Nutrition plays valuable integrated role optimising performance of elite players during training match-play, maintaining their overall health throughout the season. An evidence-based approach to nutrition emphasising, 'food first' philosophy (ie, food over supplements), fundamental ensure effective player support. This requires relevant scientific evidence be applied...
ABSTRACT Purpose Musculoskeletal injuries necessitate periods of disuse (i.e., limb immobilization) during which rapid skeletal muscle atrophy occurs. The relative susceptibility different muscles the thigh to remains uninvestigated. We assessed individual throughout 1 wk unilateral knee immobilization. Methods Thirteen healthy, young (20.2 ± 0.6 yr) men underwent 7 d leg immobilization via bracing. Magnetic resonance imaging scans were performed bilaterally prior to, and following 2...
It remains unclear whether non–animal-derived dietary protein sources (and therefore vegan diets) can support resistance training-induced skeletal muscle remodeling to the same extent as animal-derived sources. In Phase 1, 16 healthy young adults (m = 8, f 8; age: 23 ± 1 y; BMI: kg/m2) completed a 3-d intervention (high protein, 1.8 g·kg bm−1·d−1) where was derived from omnivorous (OMNI1; n 8) or exclusively non-animal (VEG1; sources, alongside daily unilateral leg exercise. Resting and...
The ability to maintain skeletal muscle mass appears be impaired in insulin-resistant conditions, such as type 2 diabetes, that are characterized by lipid accumulation. current study investigated the effect of acutely increasing availability on protein synthesis. Seven healthy young male volunteers underwent a 7-h intravenous infusion l-[ring-2H5]phenylalanine two randomized occasions combined with 0.9% saline or 10% Intralipid at 100 mL/h. After 4-h “basal” period, 21-g bolus amino acids...
Abstract The anabolic potential of a dietary protein is determined by its ability to elicit postprandial rises in circulating essential amino acids and insulin. Minimal data exist regarding the bioavailability insulinotropic effects non-animal-derived sources. Mycoprotein sustainable rich source protein. We investigated impact mycoprotein ingestion, dose–response manner, on acute hyperaminoacidaemia hyperinsulinaemia. In all, twelve healthy young men completed five experimental trials...
Short-term muscle disuse has been reported to lower both postabsorptive and postprandial myofibrillar protein synthesis rates. This study assessed the impact of on daily rates following short-term (2 7 days) under free living conditions. Thirteen healthy young men (age: 20 ± 1 yr; BMI: 23 kg/m −2 ) underwent days unilateral leg immobilization via a knee brace, with nonimmobilized acting as control. Four before participants ingested 400 mL 70% deuterated water, 50-mL doses consumed...
Abstract Background Creatine supplementation has been proposed to alleviate muscle loss in various populations, but not investigated hemodialysis (HD) patients. Thus, our objective was evaluate whether creatine could attenuate the of lean body mass (LBM) and malnutrition‐inflammation score (MIS) HD Methods A randomized, placebo‐controlled, double blind, parallel‐design study included patients, both sexes, aged 18–59 years. The patients were allocated a Placebo Group (PG; n = 15; received...
Substituting dietary meat and fish for mycoprotein, a fungal-derived food source rich in protein fibre, decreases circulating cholesterol concentrations laboratory-controlled studies. However, whether these findings can be translated to home-based setting, decrease overweight hypercholesterolemic individuals, remains established.