A5031903364- Burn Injury Management and Outcomes
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Injury Epidemiology and Prevention
- Mitochondrial Function and Pathology
- Wound Healing and Treatments
- Folate and B Vitamins Research
- Thermal Regulation in Medicine
- Exercise and Physiological Responses
- Cardiac Arrest and Resuscitation
- Thermoregulation and physiological responses
- Metabolism and Genetic Disorders
- Muscle Physiology and Disorders
- Diet and metabolism studies
- Coronary Interventions and Diagnostics
- Peripheral Artery Disease Management
- Cardiac Imaging and Diagnostics
- Metabolomics and Mass Spectrometry Studies
- Digestive system and related health
- Cardiovascular and exercise physiology
- Cardiovascular Disease and Adiposity
- Adipokines, Inflammation, and Metabolic Diseases
- Amino Acid Enzymes and Metabolism
- Fibroblast Growth Factor Research
- Cancer Research and Treatments
Arkansas Children's Hospital
2021-2025
University of Arkansas for Medical Sciences
2019-2025
Arkansas Children's Nutrition Center
2020-2024
St. Francis Hospital
2019-2024
The University of Texas Medical Branch at Galveston
2013-2023
Charles University
2023
University of Exeter
2023
Thomayer University Hospital
2023
Cardiovascular Research Foundation
2019-2021
University of Oklahoma Health Sciences Center
2021
Brown adipose tissue (BAT) has attracted scientific interest as an antidiabetic owing to its ability dissipate energy heat. Despite a plethora of data concerning the role BAT in glucose metabolism rodents, (if any) humans remains unclear. To investigate whether activation alters whole-body homeostasis and insulin sensitivity humans, we studied seven BAT-positive (BAT+) men five BAT-negative (BAT−) under thermoneutral conditions after prolonged (5–8 h) cold exposure (CE). The two groups were...
Loss of mitochondrial competency is associated with several chronic illnesses. Therefore, strategies that maintain or increase function will likely be benefit in numerous clinical settings. Endurance exercise has long been known to the skeletal muscle. Comparatively little regarding effect resistance training (RET) on muscle respiratory function.The purpose current study was determine capacity and function.Here, we studied a 12-wk RET program 11 young healthy men. Muscle biopsies were...
Mitochondrial health is critical to physiological function, particularly in tissues with high ATP turnover, such as striated muscle. It has been postulated that derangements skeletal muscle mitochondrial function contribute impaired physical older adults. Here, we determined respiratory capacity and coupling control biopsies obtained from young Twenty-four (28 ± 7 yr) thirty-one (62 8 adults were studied. respiration was permeabilized myofibers the vastus lateralis after addition of...
Abstract The trans-sulfuration enzyme cystathionine-β-synthase (CBS) and its product hydrogen sulfide (H2S) are aberrantly upregulated in colorectal cancers, where they contribute to tumor growth progression by both autocrine paracrine mechanisms. However, it is unknown whether the CBS/H2S axis plays a role carcinogenesis. Here, we report upregulation of CBS human biopsies precancerous adenomatous polyps show that forced an adenoma-like colonic epithelial cell line sufficient induce...
Obesity is associated with insulin resistance (IR) development, a risk factor for type 2 diabetes (T2D). How mitochondrial bioenergetics, in adipose tissue (AT), differs according to distinct metabolic profiles (i.e. sensitive (IS), IR normoglycaemic (IR-NG), pre-diabetes (PD) and T2D) still poorly understood. The purpose of this study was evaluate compare bioenergetics energy substrate preference by omental AT (OAT) subcutaneous (SAT) from subjects obesity (OB, n = 40) at stages....
Severe thermal injury induces a pathophysiological response that affects most of the organs within body; liver, heart, lung, skeletal muscle among others, with inflammation and hyper-metabolism as hallmark post-burn damage. Oxidative stress has been implicated key component in development inflammatory metabolic responses induced by burn. The goal current study was to evaluate several critical mitochondrial functions mouse model severe burn injury. Mitochondrial bioenergetics, measured...
The purpose of this study was to determine the effects early outpatient exercise on muscle mass, function, and fractional synthetic rate in severely burned children.Forty-seven children with ≥40% total body surface area burn performed a 12-wk standard care rehabilitation (SOC, n = 23) or rehabilitative training (RET, 24) immediately after hospital discharge. Dual-energy x-ray absorptiometry used assess lean mass (LBM) at discharge, posttreatment, 12 months post-burn. Muscle function...
Elevated metabolic rate is a hallmark of the stress response to severe burn injury. This mediated in part by adrenergic and responsive changes ambient temperature. We hypothesize that uncoupling oxidative phosphorylation skeletal muscle mitochondria contributes increased survivors. Here, we determined mitochondrial function healthy severely burned adults. Indirect calorimetry was used estimate patients. Quadriceps biopsies were collected on two separate occasions (11 ± 5 21 8 days...
Acute alterations in skeletal muscle protein metabolism are a well-established event associated with the stress response to burns. Nevertheless, long-lasting effects of burn injury on turnover incompletely understood. This study was undertaken investigate fractional synthesis (FSR) and breakdown (FBR) rates pediatric patients (n = 42, >30% total body surface area burns) for up 1 year after injury. Skeletal kinetics were measured post-prandial state following bolus injections 13C6 15N...
Burn trauma results in prolonged hypermetabolism and skeletal muscle wasting. How contributes to wasting burn patients remains unknown. We hypothesized that oxidative stress, cytosolic protein degradation, mitochondrial stress as a result of contribute cachexia postburn. Patients ( n = 14) with burns covering >30% their total body surface area were studied. Controls 13) young healthy adults. found profoundly hypermetabolic at both the systemic levels, indicating increased oxygen...
Brown adipose tissue (BAT) plays an important role in thermoregulation rodents. Its temperature homeostasis people is less studied. To this end, we recruited 18 men [8 individuals with no/minimal BAT activity (BAT-) and 10 pronounced (BAT+)]. Each volunteer participated a 6 h, individualized, non-shivering cold exposure protocol. was quantified using positron emission tomography/computed tomography. Body core skin temperatures were measured telemetric pill wireless thermistors, respectively....
• Nephropathlc cystinosis causes renal death by approximately age 10 years. With increased life span due to kidney transplantation, ten 25 years of cystine accumulation has resulted in pancreatic complications individuals with cystinosis. We noted severe hyperglycemia five posttransplant patients, three whom remained insulin-dependent diabetics several after transPlant. The clinical findings were not consistent steroid-dependent or insulin-resistant diabetes. Pancreatic deposition was...
The long-term impact of burn trauma on skeletal muscle bioenergetics remains unknown. Here, the authors determined respiratory capacity and function mitochondria in healthy individuals victims for up to 2 years postinjury. Biopsies were collected from m. vastus lateralis 16 men (26 ± 4 years) 69 children (8 5 with burns encompassing ≥30% their total BSA. Seventy-nine biopsies cohorts at weeks (n = 18), 6 months 12 25), 24 18) postburn. Hypermetabolism was by difference predicted measured...