A5015327454- Renal Diseases and Glomerulopathies
- Chemotherapy-induced organ toxicity mitigation
- Acute Kidney Injury Research
- Dialysis and Renal Disease Management
- Adolescent and Pediatric Healthcare
- Pediatric Urology and Nephrology Studies
- Ion Transport and Channel Regulation
- Kidney Stones and Urolithiasis Treatments
- Electrolyte and hormonal disorders
- Renal and related cancers
- Pharmaceutical studies and practices
- Renal Transplantation Outcomes and Treatments
- Health Systems, Economic Evaluations, Quality of Life
- Pregnancy and Medication Impact
- Innovations in Medical Education
- Childhood Cancer Survivors' Quality of Life
- Autoimmune Bullous Skin Diseases
- Chronic Kidney Disease and Diabetes
- Neurological Complications and Syndromes
- Clinical Reasoning and Diagnostic Skills
- Growth Hormone and Insulin-like Growth Factors
- Pancreatitis Pathology and Treatment
- Health Sciences Research and Education
- Nausea and vomiting management
- Parvovirus B19 Infection Studies
University of Manitoba
1996-2024
Square Hospitals
2023
Royal Darwin Hospital
2023
Texas Children's Hospital
2023
Baylor College of Medicine
2023
Newcastle upon Tyne Hospitals NHS Foundation Trust
2023
Great North Children's Hospital
2023
Royal Victoria Infirmary
2023
Wake Forest University
2023
Emory University
2023
<h3>Importance</h3> Few multicenter pediatric studies have comprehensively described the epidemiologic characteristics of cisplatin-associated acute kidney injury using standardized definitions. <h3>Objective</h3> To examine rate and risk factors associated with among children receiving cisplatin infusions. <h3>Design, Setting, Participants</h3> This prospective cohort study examined (aged <18 years) recruited from May 23, 2013, to March 31, 2017, at 12 Canadian academic health centers...
<h3>Background</h3> The contribution of copy-number variation (CNV) to disease has been highlighted with the widespread adoption array-based comparative genomic hybridisation (aCGH) and microarray technology. Contiguous gene deletions involving <i>ANKRD11</i> in 16q24.3 are associated autism spectrum disorder (ASD) intellectual disability (ID), while 16q24.1 affecting <i>FOXF1</i> congenital renal malformations, alveolar capillary dysplasia, various other abnormalities. associations...
De novo DSA (dnDSA) after renal transplantation has been shown to correlate with antibody-mediated rejection and allograft loss. However, the lack of proven interventions time cost associated annual screening for dnDSA are difficult justify all recipients. We studied a well-characterized consecutive cohort (n=949) over fifteen years prospective surveillance identify risk factors that would help institute resource-responsible strategy. Younger recipient age HLA-DR/DQ molecular mismatch were...
The lack of adequate randomized clinical trials (RCT) has hindered identification new therapies that are safe and effective for patients with primary focal segmental glomerulosclerosis (FSGS), especially in who fail to respond corticosteroids immunosuppressive therapies. Recent basic science advances have led development alternative treatments specifically target aberrant pathways fibrosis which relevant disease progression FSGS. There is a need flexible Phase II study design will test such...
Background. Steroid-dependent, steroid-resistant or frequently relapsing nephrotic syndrome carries a poor prognosis, including progression to renal failure. There are number of studies confirming the efficacy FK506 in steroid-dependent syndrome. Although use this medication is becoming more common, we know very little about potential nephrotoxicity when used Method. We retrospectively reviewed characteristics and biopsy findings 11 children with treated FK506. Two sequential biopsies were...
The greatest risk factor for kidney stones is hypercalciuria, the etiology of which largely unknown. A recent genome-wide association study (GWAS) linked hypercalciuria and to a claudin-14 (CLDN14) haplotype. However, underlying molecular mechanism was not delineated. Recently, renal CLDN14 expression found increase in response increased plasma calcium, thereby inducing calciuria. We hypothesized therefore that some children with harbor variant inappropriately increases gene expression. To...
Glycogen storage disease 1b (GSD 1b) is caused by a deficiency of glucose-6-phosphate translocase and the intracellular accumulation glycogen. The presents with failure to thrive, hepatomegaly, hypoglycemia, lactic acidosis, as well neutropenia causing increased susceptibility pyogenic infections. We present case young woman GSD who developed acute myelogenous leukemia while on long-term granulocyte colony-stimulating factor therapy. presence two rare diseases in single patient raises...
(1) To provide commentary on the 2017 update to Kidney Disease Improving Global Outcomes (KDIGO) Clinical Practice Guideline Update for Diagnosis, Evaluation, Prevention, and Treatment of Chronic Disease-Mineral Bone Disorder (CKD-MBD); (2) apply evidence-based guideline implementation within Canadian health care system; (3) comment children with chronic kidney disease (CKD); (4) identify research priorities patients.The KDIGO CKD-MBD.The committee co-chairs selected potential members based...
Nephrotic syndrome is a commonly acquired kidney disease in children that causes significant morbidity due to recurrent episodes of heavy proteinuria. The management childhood nephrotic known be highly variable among physicians and care centres.The primary objective the study determine centre-, physician-, patient-level characteristics associated with steroid exposure length treatment. We will also association dose duration treatment time first relapse as secondary aim. An embedded...
Background: Childhood cancer survivors experience adverse drug events leading to lifelong health issues. The Applying Biomarkers Minimize Long-Term Effects of Childhood/Adolescent Cancer Treatment (ABLE) team was established validate and apply biomarkers treatment effects, with a goal identifying children at high risk developing complications associated thrombosis, graft-versus-host disease, hearing loss, kidney damage. Cisplatin is chemotherapy well known cause acute chronic nephrotoxicity....
The Royal College of Physicians and Surgeons Canada, with its Competence by Design initiative, is adopting the principles competency-based medical education for residency training continuing professional development. This initiative being undertaken to meet new standards in which include social accountability performance-based outcomes training. Nephrology poised implement into July 2018 initiate a continuous quality improvement cycle periodically renew update requirements be socially...
Abstract We describe the experience of focal segmental glomerulosclerosis clinical trial (FSGS CT) in identification and recruitment participants into study. This National Institutes Health funded study, a multicenter, open‐label, randomized comparison cyclosporine versus oral dexamethasone pulses plus mycophenolate mofetil, experienced difficulty delays meeting enrollment goals. These problems occurred despite support patient advocacy groups aggressive strategies. Multiple barriers were...
Purpose of program: Integrated knowledge translation (IKT) is a collaborative approach whereby created through health research utilized in ways that are relevant to the needs all stakeholders. However, teams have limited capacity and know-how for achieving IKT, resulting disconnect between generation application knowledge. The goal this report describe how IKT was achieved across large-scale, patient-oriented network, Canadians Seeking Solutions Innovations Overcome Chronic Kidney Disease...
Epstein-Barr virus (EBV) chronic high viral load (CHVL) may be defined by >16 000 copies/mL whole blood or >200 copies/105 peripheral mononuclear cells in >50% samples exceeding 6 mo. EBV CHVL has only been characterized a few small pediatric studies, with heterogeneous results and unclear clinical significance. This single-center observational study evaluated adult kidney transplant recipients transplanted between 2010 2021 on tacrolimus/mycophenolate-based/prednisone immunosuppression. The...