James B. Johnston

ORCID: 0000-0001-6005-2142
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About
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Research Areas
  • Cancer therapeutics and mechanisms
  • Chemotherapy-induced cardiotoxicity and mitigation
  • DNA Repair Mechanisms
  • Biochemical and Molecular Research
  • Cancer Diagnosis and Treatment
  • Tracheal and airway disorders
  • Chronic Lymphocytic Leukemia Research
  • Cytomegalovirus and herpesvirus research
  • Bioactive Compounds and Antitumor Agents
  • Metal complexes synthesis and properties
  • Antioxidant Activity and Oxidative Stress
  • Healthcare Systems and Challenges
  • Central Venous Catheters and Hemodialysis
  • Chronic Myeloid Leukemia Treatments
  • Ear Surgery and Otitis Media
  • Acute Lymphoblastic Leukemia research
  • Vascular Anomalies and Treatments
  • Healthcare Policy and Management
  • HIV/AIDS drug development and treatment
  • Algal biology and biofuel production
  • vaccines and immunoinformatics approaches
  • Metastasis and carcinoma case studies
  • Bone and Joint Diseases
  • Pancreatic function and diabetes
  • HIV, Drug Use, Sexual Risk

Counties Manukau District Health Board
2024

British Columbia Institute of Technology
2023

University of Manitoba
1986-2021

National Academies of Sciences, Engineering, and Medicine
2014

University of Calgary
2001

Research Manitoba
1992-1993

National Institutes of Health
1983

King's College - North Carolina
1961

King's College Hospital
1961

London Chest Hospital
1959

The experimental immunosuppressive drug FK 506 was given to 36 renal transplant recipients, many of whom were highly sensitized. Ten undergoing kidney retransplantation, 10 also underwent liver transplantation at an earlier time (6 patients) or concomitantly (4 patients), and 2 patients received a third organ (heart pancreas) in addition kidney. With follow-ups 4 13 months, all but the are alive, 29 (81%) dialysis free, most have good function. Twenty dialysis-free receiving no low-dose (2.5...

10.1001/jama.1990.03450010067032 article EN JAMA 1990-07-04

Abstract Human endogenous retroviruses (HERVs) have been implicated as causative agents in diseases characterized by inflammation and macrophage activation, such multiple sclerosis. Because monocyte activation differentiation influence retroviral transcription replication, we investigated the contribution of these processes to expression four HERV families (HERV‐W, HERV‐K, HERV‐E, HERV‐H) human monocytes autopsied brain tissue from patients with associated increased activity. Reverse...

10.1002/ana.1131 article EN Annals of Neurology 2001-08-10

Abstract Bisphosphonates are commonly used in the treatment and prevention of osteoporosis, they also an important therapeutic adjunct multiple myeloma other cancers metastatic to bone. generally well tolerated associated with minimal adverse effects; however, there exists a growing concern that intravenous bisphosphonate use is osteonecrosis jaw (ONJ). We report occurrence pamidronate therapy 12 patients diagnosed myeloma, breast carcinoma, or renal cell all involving At onset...

10.1002/ajh.20481 article EN American Journal of Hematology 2005-12-20

Children with otitis media who are referred to paediatric otorhinolaryngology (ORL) departments often experience significant delays in treatment. Alternate models of care utilising audiologists extended scopes practice can potentially improve outcomes services experiencing difficulties high demand and insufficient ORL capacity. An Advanced Audiology Practitioner (AAP) service was implemented Counties Manukau combat known long wait times for children media. This study aimed retrospectively...

10.1080/03036758.2024.2344773 article EN Journal of the Royal Society of New Zealand 2024-05-01

In animals carotenoids show biological activity unrelated to vitamin A that has been considered arise directly from the behavior of parent compound, particularly as an antioxidant. However, very property confers antioxidant on some in plants also susceptibility oxidative transformation. As alternative, it suggested carotenoid breakdown or metabolic products could be actual agents animals. important and neglected aspect highly unsaturated is their potential undergo addition oxygen form...

10.1371/journal.pone.0111346 article EN cc-by PLoS ONE 2014-10-31

Objectives HIV point-of-care testing (POCT) has been available in Manitoba since 2008. This study evaluated the effectiveness of POCT at identifying individuals with previously unknown status, its effects on clinical outcomes and characteristics populations reached. Methods A retrospective database review was conducted for who received from 2011 to 2014. Time linkage care viral load suppression were compared between tested positive using controls identified as through standard screening....

10.1136/sextrans-2017-053195 article EN Sexually Transmitted Infections 2017-10-07

10.1016/s0022-5223(20)31942-5 article EN publisher-specific-oa Journal of Thoracic and Cardiovascular Surgery 1961-10-01

10.1016/s0140-6736(02)38804-4 article CA ˜The œLancet 1857-08-01

La tuberculose résistante aux médicaments est un problème de santé mondial majeur, en partie parce qu'il y existe moins traitements efficaces et que ces sont prolongés plus toxiques.Les données probantes pour des efficaces, courts normalisés évoluent rapidement.Nous signalons ici le premier cas pulmonaire pré-ultrarésistante traité au moyen d'un nouveau traitement bédaquiline, préomanide linézolide (BPaL) par voie orale d'une durée six mois Canada.Les d'essais cliniques récents à l'appui la...

10.14745/ccdr.v49i01a04f article FR cc-by Relevé des maladies transmissibles au Canada 2023-01-24
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