A5023684801- Tuberculosis Research and Epidemiology
- Infectious Diseases and Tuberculosis
- Enzyme-mediated dye degradation
- Lignin and Wood Chemistry
- Pneumonia and Respiratory Infections
- DNA and Nucleic Acid Chemistry
- Biochemical and biochemical processes
- Advanced biosensing and bioanalysis techniques
- Diagnosis and treatment of tuberculosis
- Fungal Biology and Applications
- Infectious Disease Case Reports and Treatments
- Actinomycetales infections and treatment
- Biofuel production and bioconversion
- Infective Endocarditis Diagnosis and Management
- Inorganic and Organometallic Chemistry
- HIV/AIDS Research and Interventions
- RNA Interference and Gene Delivery
- Emergency and Acute Care Studies
- Chronic Lymphocytic Leukemia Research
- Chemical Synthesis and Reactions
- Ocular Diseases and Behçet’s Syndrome
- Central Venous Catheters and Hemodialysis
- Urological Disorders and Treatments
- Orthopedic Infections and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
University of British Columbia
2019-2025
BC Centre for Disease Control
2022-2025
St. Paul's Hospital
2025
Vancouver General Hospital
2023
British Columbia Institute of Technology
2023
Providence Health Care
2022
AstraZeneca (United States)
2022
University of Calgary
2012-2019
Lions Gate Hospital
2019
Vancouver Coastal Health
2019
Decomposition of 14 C-labeled lignin to CO 2 by the lignin-decomposing fungi Phanerochaete chrysosporium and Coriolus versicolor required a growth substrate such as cellulose or glucose. Growth with sole carbon addition an otherwise complete medium was negligible.
A definitive assay for microbiological and biochemical research on the biodegradation of lignin was developed using radioactive synthetic lignins specifically labeled in side chains, aromatic rings or methoxyl groups. The [14C]lignins were prepared by oxidative polymerization with peroxidase H2O2 Of coniferyl alcohol (4-hydroxy-3-methyoxycinnamyl alcohol). polymers shown spectroscopic chemical methods to contain same intermonomer linkages found natural lignins. Incubation known...
Lignin biodegradation in a variety of natural materials was examined using specifically labeled synthetic 14 C-lignins. Natural included soils, sediments, silage, steer bedding, and rumen contents. Both aerobic anaerobic incubations were used. No C-labeled lignin to gaseous products under conditions observed. Aerobic mineralization varied with respect type material used, site, soil horizon, temperature. The greatest observed degradation occurred from Yellowstone National Park amounted over...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSecondary Structure and Aggregation in Deoxyguanosine OligonucleotidesR. K. Ralph, W. J. Connors, H. G. KhoranaCite this: Am. Chem. Soc. 1962, 84, 11, 2265–2266Publication Date (Print):June 1, 1962Publication History Published online1 May 2002Published inissue 1 June 1962https://pubs.acs.org/doi/10.1021/ja00870a055https://doi.org/10.1021/ja00870a055research-articleACS PublicationsRequest reuse permissionsArticle Views251Altmetric-Citations63LEARN...
Abstract Background Rifampin-resistant tuberculosis is a leading cause of morbidity worldwide; only one-third persons start treatment, and outcomes are often inadequate. Several trials demonstrate 90% efficacy using an all-oral, 6-month regimen bedaquiline, pretomanid, linezolid (BPaL), but significant toxicity occurred 1200-mg linezolid. After US Food Drug Administration approval in 2019, some clinicians rapidly implemented BPaL initial 600-mg dose adjusted by serum drug concentrations...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on Polynucleotides. XVIII.1Experiments the Polymerization of Mononucleotides. The Synthesis and Characterization Deoxyguanosine Oligonucleotides2R. K. Ralph, W. J. Connors, H. Schaller, G. KhoranaCite this: Am. Chem. Soc. 1963, 85, 13, 1983–1988Publication Date (Print):July 1, 1963Publication History Published online1 May 2002Published inissue 1 July...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew structures from the enzymic dehydrogenation of lignin model p-hydroxy-.alpha.-carbinolsJ. C. Pew and W. J. ConnorsCite this: Org. Chem. 1969, 34, 3, 580–584Publication Date (Print):March 1, 1969Publication History Published online1 May 2002Published inissue 1 March 1969https://pubs.acs.org/doi/10.1021/jo01255a021https://doi.org/10.1021/jo01255a021research-articleACS PublicationsRequest reuse permissionsArticle Views138Altmetric-Citations30LEARN...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymic dehydrogenation of the lignin model coniferaldehydeWilliam J. Connors, Chen-Loung Chen, and John C. PewCite this: Org. Chem. 1970, 35, 6, 1920–1924Publication Date (Print):June 1, 1970Publication History Published online1 May 2002Published inissue 1 June 1970https://pubs.acs.org/doi/10.1021/jo00831a044https://doi.org/10.1021/jo00831a044research-articleACS PublicationsRequest reuse permissionsArticle Views204Altmetric-Citations23LEARN ABOUT...
We report the use of IV dalbavancin in Canadian patients using data captured by national CLEAR registry. The registry uses web-based management program, REDCapTM (online survey https://rcsurvey.radyfhs.umanitoba.ca/surveys/?s=TPMWJX98HL) to facilitate clinicians entering details associated with their clinical experiences dalbavancin. Data were available for 40 patients. most common infections treated acute bacterial skin and structure infection (ABSSSI) (62.5% patients), bone/joint (22.5%),...
Abstract Background Tuberculosis (TB) remains a significant global health threat. Upon diagnosis, patients with pulmonary TB are required to undergo specific isolation precautions prevent further disease transmission. Current practice typically mandates for at least two weeks post-diagnosis, extended periods those found have positive sputum acid fast bacilli (AFB) smear results. The most recent Canadian Standards (2022) and other international groups suggested that the decision discontinue...
Background: Updated global tuberculosis (TB) guidelines recommend the novel oral 6-month bedaquiline, pretomanid, linezolid, and moxifloxacin (BPaLM) regimen for multidrug-resistant TB (MDR-TB) based on superior efficacy reduced toxicity demonstrated in clinical trials. These trials were dominated by isolated pulmonary TB; thus, data BPaLM effectiveness extrapulmonary (EPTB) remains limited. Methods: We describe safe effective use of a patient treatment MDR-TB involving an site. Results:...
Background: Rifampin-resistant (RR) and multidrug-resistant (MDR) tuberculosis (TB) previously required treatment with a protracted course of toxic second-line TB drugs suboptimal efficacy. Novel 6-month regimens bedaquiline, pretomanid, linezolid ± moxifloxacin (BPaL/M) are now recommended, but implementation in Canada is not well described. Methods: We analyzed eight people MDR or pre–extensively drug-resistant (pre-XDR) rifamycin intolerance treated BPaL/M Western to inform expanded use....
Lymphomatoid granulomatosis (LYG) is a rare Epstein-Barr virus-associated lymphoproliferative disorder. It most often occurs in patients with immunodeficiency and the clinical course ranges from indolent behavior to that of an aggressive malignancy. Pulmonary, central nervous system dermatological manifestations are common. To our knowledge this first reported case LYG related azathioprine therapy Crohn disease. A twenty-six year old Caucasian woman colonic disease on maintenance presented...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew structures from enzymic dehydrogenation of lignin model p-hydroxypropiophenonesJ. C. Pew and W. J. ConnorsCite this: Org. Chem. 1969, 34, 3, 585–589Publication Date (Print):March 1, 1969Publication History Published online1 May 2002Published inissue 1 March 1969https://doi.org/10.1021/jo01255a022RIGHTS & PERMISSIONSArticle Views97Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum full text article...
Quinolones are antibacterial drugs that thought to bind preferentially disturbed regions of DNA. They do not fall into the classical categories intercalators, groove binders or electrostatic backbone. We solved 3D structure DNA duplex (ACGCGU-NA) 2 , where NA denotes a nalidixic acid residue covalently linked 2′-position 2′-amino-2′-deoxyuridine, by NMR and restrained torsion angle molecular dynamics (MD). In complex, quinolones stack on G:C base pairs core tetramer disrupt terminal A:U...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbonyl compounds from dehydrogenation of p-cresolChen-Lung Chen, W. J. Connors, and M. ShinkerCite this: Org. Chem. 1969, 34, 10, 2966–2971Publication Date (Print):October 1, 1969Publication History Published online1 May 2002Published inissue 1 October 1969https://pubs.acs.org/doi/10.1021/jo01262a035https://doi.org/10.1021/jo01262a035research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations14LEARN ABOUT THESE...
The number of Acute Dental Infections (ADI) presenting for emergency department (ED) care are steadily increasing. Outpatient Parenteral Antibiotic Therapy (OPAT) programs increasingly utilized as an alternative cost-effective approach to the management serious infectious diseases but their role in severe ADI is not established. This study aims address this knowledge gap through evaluation referrals a regional OPAT program large Canadian center. All adult ED and from four acute hospitals...