A5083326383- Pharmacogenetics and Drug Metabolism
- Analytical Chemistry and Chromatography
- Drug Transport and Resistance Mechanisms
- Inflammatory mediators and NSAID effects
- Analytical Methods in Pharmaceuticals
- Antibiotics Pharmacokinetics and Efficacy
- Receptor Mechanisms and Signaling
- Eicosanoids and Hypertension Pharmacology
- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- Hormonal Regulation and Hypertension
- Rheumatoid Arthritis Research and Therapies
- Cancer Treatment and Pharmacology
- Drug-Induced Hepatotoxicity and Protection
- Renin-Angiotensin System Studies
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Crystallization and Solubility Studies
- Pharmaceutical studies and practices
- Blood disorders and treatments
- Pain Mechanisms and Treatments
- Mass Spectrometry Techniques and Applications
- Molecular spectroscopy and chirality
- Computational Drug Discovery Methods
- Vitamin D Research Studies
Doncaster Royal Infirmary
2024
University of Alberta
2011-2020
Pharmaceutical Biotechnology (Czechia)
2011
University of Tehran
1980-2004
Temple University
1996
Royal Alexandra Hospital
1987-1988
University of British Columbia
1973-1978
Aims Inflammation reduces hepatic clearance of many drugs with unknown therapeutic consequences. This study was carried out to examine the effect rheumatoid arthritis (RA) on pharmacokinetics and pharmacodynamics verapamil. Methods Eight RA patients were age‐ sex‐matched eight healthy volunteers. The disease severity assessed, ECG, blood pressure verapamil enantiomers concentrations measured for 12 h post 80 mg oral Serum interleukin‐6 (IL‐6) nitrite (NO 2 – ) in predose samples. Results...
The 2-arylpropionic acid nonsteroidal anti-inflammatory drugs are usually administered as racemates. enantiomers may have different pharmacokinetics and the R-isomer metabolically invert to S-isomer. To pinpoint kinetics of inversion location in which this metabolic process takes place, racemic ketoprofen (KT) was rat. Using a stereospecific HPLC assay, KT were studied following 10 mg/kg iv, po, ip doses male Sprague-Dawley rats. Plasma concentrations always greater for (S)-KT than (R)-KT....
Twelve patients with either rheumatoid or psoriatic arthritis were injected a 10-mg bolus dose of methotrexate (MTX) intramuscularly (n = 6) intravenously and the MTX concentration in their sera was determined by radioimmunoassay. concentration-time data fitted triexponential equations. Doses rapidly completely absorbed. There no significant intergroup differences drug mean t½, volume distribution, total body clearance. In nine serum concentrations remained above suggested critical level...
Eighteen infants with idiopathic apnea of prematurity refractory to therapeutic levels aminophylline were treated incremental doses doxapram beginning at 0.5 mg/kg/h. Continuous recording heart rate, thoracic impedance, and transcutaneous PO2 demonstrated that 47% the satisfied objective response criteria lowest dose, 53% responded 1.0 mg/kg/h, 65% 1.5 82% 2.0 89% highest allowed dose 2.5 The mean serum concentration was 2.9 +/- 1.3 micrograms/mL, all who had greater than micrograms/mL. BP...
This stereospecific "high-performance" liquid-chromatographic (HPLC) assay is suitable for pharmacokinetic studies of ibuprofen (IB). Very efficient extraction the drug and internal standard, (+/-)-2-(4-benzoylphenyl)butyric acid, from plasma with isooctane/isopropanol (95/5, by vol) followed sequential reaction enantiomers ethyl chloroformate (S)-(-)-1-(1-naphthyl)ethylamine. The reactions take place at ambient temperature in less than 4 min. naphthylethylamide derivatives IB standard are...
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Inflammatory conditions such as Crohn's disease are associated with cardiovascular complications. Inflammation also substantially reduces clearance of some drugs. It has been shown that in rheumatoid arthritis, an elevation verapamil concentration does not result increased response. STUDY ADDS A reduced response upon another inflammatory condition, bowel disease, different aetiology from arthritis was found. Interestingly, however, a mere affliction...