A5028012174- Dialysis and Renal Disease Management
- Chronic Kidney Disease and Diabetes
- Atrial Fibrillation Management and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Acute Kidney Injury Research
- Central Venous Catheters and Hemodialysis
- Blood Pressure and Hypertension Studies
- Renal and Vascular Pathologies
- Sodium Intake and Health
- Venous Thromboembolism Diagnosis and Management
- Organ Transplantation Techniques and Outcomes
- Acute Ischemic Stroke Management
- Healthcare cost, quality, practices
- Cardiac, Anesthesia and Surgical Outcomes
- Renal Transplantation Outcomes and Treatments
- Heart Failure Treatment and Management
- Parathyroid Disorders and Treatments
- Pharmaceutical Practices and Patient Outcomes
- Lipoproteins and Cardiovascular Health
- Pregnancy and Medication Impact
- Medication Adherence and Compliance
- Renal function and acid-base balance
- Potassium and Related Disorders
- Organ Donation and Transplantation
- Meta-analysis and systematic reviews
McMaster University
2016-2025
Population Health Research Institute
2021-2025
Hamilton Health Sciences
2024-2025
Institute for Clinical Evaluative Sciences
2016-2025
St. Joseph’s Healthcare Hamilton
2016-2024
Impact
2018-2024
Ghent University Hospital
2023-2024
St. Joseph's Hospital
2023
Ontario Stroke Network
2019
Central University Hospital of Asturias
2018
New staging systems for CKD account both reduced eGFR and albuminuria; whether each measure associates with greater risk of hemorrhage is unclear. In this retrospective cohort study (2002–2010), we grouped 516,197 adults ≥40 years old by (≥90, 60 to <90, 45 <60, 30 <45, 15 <30, or <15 ml/min per 1.73 m 2 ) urine albumin-to-creatinine ratio (ACR; >300, 30–300, <30 mg/g) examine incidence hemorrhage. The 3-year cumulative increased 20-fold across declining increasing ACR...
Statins abrogate ischemic renal injury in animal studies but whether they are renoprotective humans is unknown. We conducted a population-based retrospective cohort study that included 213,347 older patients who underwent major elective surgery the province of Ontario, Canada from 1995 to 2008. During first 14 postoperative days, 1.9% (4020 patients), developed acute kidney and 0.5% (1173 required dialysis. The 30-day mortality rate was 2.8% (5974 patients). Prior surgery, 32% were taking...
Coronary artery calcification (CAC) is highly prevalent among dialysis patients and associated with increased cardiovascular all cause mortality. Magnesium (Mg) inhibits vascular in animal in-vitro studies but whether the same effect occurs humans uncertain. A single centre cross-sectional study of 80 peritoneal (PD) patients; on PD only for a minimum 3 months. radiologist blinded to patient status calculated their abdominal aortic (AAC) scores lateral lumbar spine radiographs, validated...
Key Points In this post hoc analysis of a randomized controlled trial, the proton pump inhibitor pantoprazole led to faster rate eGFR decline as compared with placebo. Additional studies are needed determine effect inhibitors on those at higher risk adverse kidney outcomes. Background Observational have found an association between use and worsening function. It is unclear whether these associations causal. We conducted analyses function using data from Cardiovascular Outcomes for People...
The number of patients starting dialysis is increasing world wide. Unplanned starts (patients urgently in hospital) associated with increased costs and high morbidity mortality. Risk factors for hospital have not been well studied. primary objective this study was to identify risk unplanned followed a multidisciplinary chronic kidney disease (CKD) clinic. We performed retrospective cohort 649 advanced CKD clinic at tertiary care from January 01, 2010 April 30, 2013. Patients were classified...
Contemporary data on venous thromboembolism (VTE) risk in dialysis patients are limited. Our objective was to determine the and complications of VTE among incident maintenance patients.We performed a retrospective cohort study using administrative databases. We included adult from 2004 2010 (n = 13 315). Dialysis were age- sex-matched individuals general population 1:4 ratio 53 260). determined 3-year cumulative incidence rate (IR) VTE, pulmonary embolism (PE) deep thrombosis (DVT). examined...
Background: Hospitalizations of chronic dialysis patients have not been previously studied at a national level in Canada. Understanding the scope and variables associated with hospitalizations will inform measures for improvement. Objective: To describe risk all-cause infection-related on dialysis. Design: Retrospective cohort study using health care administrative databases. Setting: Provinces territories across Canada (excluding Manitoba Quebec). Patients: Incident start date between...
Preoperative proteinuria is associated with a higher incidence of postoperative AKI. Whether the same true for uncertain. This study tested hypothesis that increased after cardiac surgery an risk AKI.This prospective cohort included 1198 adults undergoing at six hospitals between July 2007 and December 2009. Albuminuria, urine albumin-to-creatinine ratio (ACR), dipstick were measured 0-6 hours surgery. The primary outcome was AKI, defined as doubling in serum creatinine or receipt acute...
Some studies but not others suggest angiotensin converting enzyme inhibitor (ACEi) or receptor blocker (ARB) use prior to major surgery associates with a higher risk of postoperative acute kidney injury (AKI) and death. We conducted large population-based retrospective cohort study patients aged 66 years older who received elective in 118 hospitals Ontario, Canada from 1995 2010 (n = 237,208). grouped the into ACEi/ARB users 101,494) non-users 135,714) according whether patient filled at...
Background Early evidence suggests proteinuria is independently associated with incident atrial fibrillation (AF). We sought to investigate whether the association of AF altered by kidney function. Methods and Results Retrospective cohort study using administrative healthcare databases in Ontario, Canada (2002–2015). A total 736 666 patients aged ≥40 years not receiving dialysis no previous history were included. Proteinuria was defined urine albumin‐to‐creatinine ratio (ACR) function...
The transition from chronic kidney disease (CKD) to failure is a vulnerable time for patients, with suboptimal transitions associated increased morbidity and mortality. Whether social determinants of health are not well understood.This retrospective cohort study included 1070 patients advanced CKD who were referred the Ottawa Hospital Multi-Care Kidney Clinic developed (dialysis or transplantation) between 2010 2021. Social determinant information, including education level, employment...
Purpose of the Conference: Hemodialysis is a life-sustaining treatment for patients with end-stage kidney disease. However, on dialysis continue to face poor quality life and short expectancies. Despite this, nephrology community conducts fewest randomized controlled trials any medical discipline, relying instead expert opinion guide many aspects hemodialysis care. There need conduct high-quality pragmatic in drive evidence-based practice. To this end, Innovative Clinical Trials Centers...
Importance Hyperkalemia is a common complication of taking renin-angiotensin-aldosterone system inhibitor (RAASi). Post hoc analyses large randomized clinical trials suggested that the addition sodium-glucose cotransporter 2 inhibitors (SGLT2i) may attenuate this risk. It unknown if observation extends to daily practice. Objective To evaluate association between SGLT2i initiation and hyperkalemia in individuals receiving RAASi with background diabetes, heart failure, or chronic kidney...
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