A5033745015- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Congenital Diaphragmatic Hernia Studies
- Esophageal and GI Pathology
- SARS-CoV-2 and COVID-19 Research
- Lymphatic Disorders and Treatments
- Esophageal Cancer Research and Treatment
- Lung Cancer Diagnosis and Treatment
- Omental and Epiploic Conditions
- Gastrointestinal disorders and treatments
- Metastasis and carcinoma case studies
- Lymphatic System and Diseases
- Myasthenia Gravis and Thymoma
- Occupational and environmental lung diseases
- Intraperitoneal and Appendiceal Malignancies
- Cancer, Stress, Anesthesia, and Immune Response
- Neuroinflammation and Neurodegeneration Mechanisms
- COVID-19 and Mental Health
- Venous Thromboembolism Diagnosis and Management
- COVID-19 Impact on Reproduction
- Neuropeptides and Animal Physiology
- Pericarditis and Cardiac Tamponade
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pediatric Pain Management Techniques
- Vascular Tumors and Angiosarcomas
Amsterdam University Medical Centers
2020-2025
Amsterdam UMC Location Vrije Universiteit Amsterdam
2021-2024
University Medical Center
2013-2024
University Hospital and Clinics
2024
University Medical Center Utrecht
2017-2023
Heidelberg University
2018-2023
University Hospital Heidelberg
2018-2023
Utrecht University
2018-2023
Vrije Universiteit Amsterdam
2021
University of Amsterdam
2020-2021
SARS-CoV-2 causes acute respiratory disease, but many patients also experience neurological complications. Neuropathological changes with pronounced neuroinflammation have been described in individuals after lethal COVID-19, as well the CSF of hospitalized To assess whether neuropathological can occur a infection, leading to mild-to-moderate we investigated brains four rhesus and cynomolgus macaques pulmonary disease without overt clinical symptoms. Postmortem analysis demonstrated...
General anesthesia during infancy is associated with neurocognitive abnormalities. Potential mechanisms include anesthetic neurotoxicity, surgical disease, and cerebral hypoxia-ischemia. This study aimed to determine the incidence of low oxygenation factors general in infants.This multicenter enrolled 453 infants aged less than 6 months having for 30 min or more. Regional was measured by near-infrared spectroscopy. We defined events (more 3 min) as mild (60 69% 11 20% below baseline),...
COVID-19 is a pandemic with high morbidity and mortality. In an autopsy cohort of patients, we found extensive accumulation the tryptophan degradation products 3-hydroxy-anthranilic acid quinolinic in lungs, heart, brain. This was not related to expression tryptophan-catabolizing indoleamine 2,3-dioxygenase (IDO)-1, but rather that its isoform IDO-2, which otherwise expressed rarely. Bioavailability absolute requirement for proper cell functioning synthesis hormones, whereas can cause death....
Abstract SARS-CoV-2 may cause acute respiratory disease, but the infection can also initiate neurological symptoms. Here we show that causes brain inflammation in macaque model. An increased metabolic activity pituitary gland of two macaques was observed by longitudinal positron emission tomography-computed tomography (PET-CT). Post-mortem analysis demonstrated infiltration T-cells and activated microglia brain, viral RNA detected tissues from one animal. We Lewy bodies brains all rhesus...
Abstract Various lymph node functions are regulated by the sympathetic nervous system as shown in rodent studies. If human nodes show a comparable neural regulation, their afferent nerves could represent potential therapeutic target to treat, for example, infectious or autoimmune disease. Little information is available on innervation and aim of this study establish comprehensive accurate representation presence location nodes. Since previous studies mention paravascular occasionally extent...
The pandemic of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global outbreak and prompted an enormous research effort. Still, subcellular localization in lungs COVID-19 patients is not well understood. Here, SARS-CoV-2 proteins studied postmortem lung material SARS-CoV-2-infected Vero cells, processed identically. Correlative light electron microscopy on semithick cryo-sections demonstrated induction electron-lucent, lipid-filled compartments after infection...
Recently, a distinct subgroup of vascular neoplasms has been identified, characterized by NFATC-related fusions. Although existing literature is limited, these lesions histologically show variable appearance with tendency for local recurrence but not distant spread. Therefore, they likely fall within the "benign" or at most in "local aggressive"/"borderline" tumor category according to International Society Study Vascular Anomalies (ISSVA) classification scheme. Up now, tumors fusions have...
Abstract Background and objective Patients with coronavirus disease 2019 (COVID‐19) pneumonia present typical findings on chest computed tomography (CT), but the underlying histopathological patterns are unknown. Through direct regional correlation of imaging to patterns, this study aimed explain COVID‐19 CT at tissue level. Methods Eight autopsy cases were prospectively selected patients PCR‐proven varying clinical manifestations causes death. All had been subjected 24–72 h prior...
Purpose and context. Angiotensin-converting enzyme 2 is the entry receptor for SARS-CoV SARS-CoV-2. Variations in ACE2 expression might explain age-related symptomatology of COVID-19, that is, more gastro-intestinal symptoms less pulmonary complaints. This study qualitatively investigated protein various organs from fetal to young adolescent stage. Method. Autopsy samples lung, heart, liver, stomach, small intestine, pancreas, kidney, adrenals, brain (when available) were obtained twenty...
Milky spots are unique lymphoid structures in the greater omentum that participate both immune homeostasis of peritoneal cavity and formation omental metastases. We developed a rapid simple staining method to enable macro- or stereomicroscopic identification these miniscule large samples fixed human omentum. By immersing approximately 6 × 4 cm tissue hematoxylin, could be evaluated quickly for presence milky spots. used an alum hematoxylin variant containing 1 g 50 aluminium ammonium...
Omental milky spots (OMSs), small lymphoid structures positioned in the greater omentum, are involved peritoneal immune homeostasis and formation of omental metastases. Sympathetic nerve activity is known to regulate function other organs (e.g. spleen lymph nodes) create a favourable microenvironment for various tumour types. However, it still unknown whether OMSs receive sympathetic innervation. Therefore, aim this study was establish adult human omentum A total 18 were isolated from five...
BackgroundThe thoracic lymphadenectomy during an esophagectomy for esophageal cancer includes resection of the duct (TD) compartment containing TD lymph nodes (TDLNs). The role is still a topic debate since metastatic TDLNs have only been demonstrated in squamous cell carcinomas Eastern patients. Therefore, aim this study was to assess presence and involvement Western population, which adenocarcinoma predominant type cancer.MethodsFrom July 2017 May 2020, all consecutive patients undergoing...
To gain more insight into the pattern of peritoneal cancer dissemination and optimize treatment, it is important to improve our understanding omental lymphatic system. Although milky spots (OMSs) are considered only lymphoid structures in omentum, clinical studies mention presence lymph nodes (LNs) as well. This discrepancy may be explained by fact that OMSs highly dynamic erroneously mistaken for LNs. The aim this study was evaluate structures, mainly nodes, apron greater omentum. In study,...
Background Gastrointestinal symptoms are frequently reported adverse effects of antidepressants, but antidepressants also a treatment modality in functional gastrointestinal disorders. We aimed to assess the association between antidepressant use and general adult population. Methods assessed symptoms, medication use, comorbidity through structured questionnaires randomly selected individuals. compared presence respondents who with those did not. used multivariable regression analysis verify...