Loosening of primary cemented and noncemented components total hip arthroplasties always is accompanied by a loss bone stock. There are several options for reconstruction the acetabular femoral defects. The authors' treatment choice standardized revision procedure with tight impaction morsellized cancellous autograft or allograft chips in reconstructions. In this study, clinical radiographic evaluation defects reconstructed impacted heads was described. A cup supplemented grafts wire meshes...

Abstract Dendritic cells (DCs) are specialized APCs that can be activated upon pathogen recognition as well of endogenous ligands, which released during inflammation and cell stress. The exogenous ligands depends on TLRs, abundantly expressed in synovial tissue from rheumatoid arthritis (RA) patients. Furthermore TLR found to present RA serum fluid significantly increased, compared with healthy volunteers patients systemic sclerosis lupus erythematosus. Identification novel might contribute...

Ceramic-on-ceramic bearings in THA are a popular alternative to overcome wear concerns traditional metal-polyethylene bearings. However, squeaking is potentially worrisome phenomenon ceramic-on-ceramic THAs which we observed some of our patients. We reviewed all 42 patients who underwent 43 noncemented during the time study. Squeaking, defined as reproducible sound squeaking, clicking, or grating, occurred nine implants (20.9%). Standard radiographs were normal. used CT imaging determine cup...

Abstract Objective Wnt signaling pathway proteins are involved in embryonic development of cartilage and bone, and, interestingly, developmental processes appear to be recapitulated osteoarthritic (OA) cartilage. The present study was undertaken characterize the expression pattern Fz genes during experimental OA determine function selected human OA. Methods Longitudinal analysis performed 2 models Levels messenger RNA for from Wnt/β‐catenin were determined synovium cartilage, results...

Abstract Objective S100A8 and S100A9 are two Ca 2+ binding proteins classified as damage‐associated molecular patterns or alarmins that found in high amounts the synovial fluid of osteoarthritis (OA) patients. The purpose this study was to investigate whether and/or can interact with chondrocytes from OA patients increase catabolic mediators. Methods Using immunohistochemistry, we stained for protein, matrix metalloproteinases (MMPs), a cartilage‐breakdown epitope specific MMPs (VDIPEN)...

In a previous report, we presented our results of forty-two acetabular reconstructions, performed with use impaction bone-grafting and cemented polyethylene cup, in thirty-seven patients who were younger than fifty years had minimum fifteen follow-up. The present update study shows the after twenty to twenty-eight years. Eight additional cups be revised—four because aseptic loosening, three wear, one during revision stem. Three considered loose on radiographs. Survivorship an end point for...

Tibial fixation in revision total knee arthroplasty (rTKA) can present surgical challenges. It has been suggested that appropriate at least two of the three anatomical zones (epiphysis, metaphysis, and diaphysis) is essential for implant survival. However, supporting clinical data are lacking. In this retrospective case-control study, we investigated relationship between zonal hybrid rTKA tibial components re-revision aseptic loosening (rrTKA-AL).

Animal studies have shown almost complete incorporation of impacted morselized bone grafts. To determine whether this also is true in humans, 24 acetabular biopsy specimens from 21 hips 20 patients were examined. Biopsy obtained 3 months to 15 years after reconstruction primary and revision total hip arthroplasties combination with a cemented cup. Histologic examination showed rapid revascularization the graft, directly followed by osteoclastic resorption woven formation on graft remnants....

This study presents the clinical and radiological results of 62 consecutive acetabular revisions in 58 patients, at a mean 16.5 years follow-up (15 to 20). The Kaplan-Meier survivorship for cup with end-point any reason, was 79% 15 (95% confidence interval (CI); 67 91). Excluding two septic loosening three six years, one revision well-fixed after 12 course femoral revision, 84% CI; 73 95). At review there were no additional cases loosening, although seven reconstructions showed radiolucent...

We report a long-term review of 60 acetabular components revised using impacted, morsellised bone allografts and cemented polyethylene cup. The defects were cavitary (37) or combined (23). Follow-up was for mean 11.8 years (10 to 15).

Acetabular bone stock loss compromises the outcome in primary and revision total hip arthroplasty. In 1979, a biologic method was introduced with tightly impacted cancellous allografts combination cemented polyethylene cup for acetabular reconstruction. With this technique, it is possible to replace of repair normal mechanics function standard implant. Based on authors' 20 years experience, review long-term data presented arthroplasty preexisting loss, rheumatoid arthritis, patients who had...

We report a long-term review of 60 acetabular components revised using impacted, morsellised bone allografts and cemented polyethylene cup. The defects were cavitary (37) or combined (23). Follow-up was for mean 11.8 years (10 to 15). Further revision needed in five hips, two septic three aseptic loosening. overall survival rate at 90%; excluding the cases it 94%. Acetabular reconstruction with impacted cancellous grafts cement gives satisfactory results.

To simulate femoral intramedullary bone stock loss in revision surgery of failed total hip arthroplasties, a method was developed using impacted trabecular grafts. In 14 goats cemented arthroplasty performed, fixating the stem within circumferential construction allografts. After 6 or 12 weeks, 4 were used for mechanical tests and 3 histology.The stability stems determined loading experiment with roentgen-stereophotorammetric analysis; loads up to 1.44 times body weight used. One aseptic...

We present an update of the clinical and radiological results 62 consecutive acetabular revisions using impacted morsellised cancellous bone grafts a cemented component in 58 patients, at mean follow-up 22.2 years (20 to 25). The Kaplan-Meier survivorship for with revision any reason as endpoint was 75% 20 (95% confidence interval (CI) 88) when 16 hips were risk. Excluding two septic loosening three six years, 79% CI 67 93). With further exclusions one well-fixed after 12 during femoral 17...

Purpose We investigated the hypothesis that many total hip arthroplasty revisions are classified as aseptic in fact low-grade infections missed with routine diagnostics. Methods In 7 Dutch hospitals, 176 consecutive patients preoperative diagnosis of loosening their were enrolled. During surgery, between 14 and 20 tissue samples obtained for culture, pathology, broad-range 16S rRNA PCR reverse line blot hybridization. Patients either not being infected, suspected having infection, or...

Patient-Reported Outcome (PRO) measurement is a method for measuring perceptions of patients on their health and quality life. The aim this paper to present the results PRO measurements in total hip knee replacement as routinely collected during 20 years surgery university hospital setting. Data consecutive between 1993 2014 were collected. Health outcomes measured pre-surgery at 3, 6, 12 months post-surgery. Outcomes with Harris Hip Score (HHS) Oxford (OHS). Western Ontario McMaster...

Aims The aim of this study was to report the long-term follow-up cemented short Exeter femoral components when used in primary total hip arthroplasty (THA). Methods We included all 394 THAs with a component (≤ 125 mm) our tertiary referral centre between October 1993 and December 2021. A 83 patients (21%) were male. median age at time surgery 42 years (interquartile range (IQR) 30 55). main indication for THA childhood disease (202; 51%). 6.7 (IQR 3.1 11.0). Kaplan-Meier survival analyses...

We took core biopsies from the acetabulum in 8 patients (at reoperation) after a previous revision with impacted cancellous allograft chips combination cement. Except for one biopsy specimen, graft showed different stages of incorporation. In specimens taken at 4 months, revascularization was found. Osteoclasts had removed parts graft, while woven bone formed on remnants and stroma that invading graft. Subsequent this mixture new due time remodeled into normal trabecular bony structure...

The purpose of this study was to evaluate the clinical and radiographic outcomes revision femoral component a hip arthroplasty with use an impaction bone-grafting technique cemented polished stem.Thirty-three consecutive reconstructions that were performed between March 1991 February 1996 X-change system, fresh-frozen morselized allograft, Exeter stem followed prospectively. Femoral bone stock defects classified according Endoklinik classification. average age patients at time sixty-three...

AbstractWe determined the effect of bone graft particle size and impaction technique on initial stability cemented acetabular cups. First, reconstructions were performed in human cadaveric pelvic bones which type 2 AAOS cavitary defects created. Reconstructions made with small grafts (average mm) produced by a mill or large 9 hand rongeur. All chips from freshly-frozen femoral heads. Impaction was done using impactors hammer. We did loading experiment gradually increasing dynamic load up to...

Bone defects in revision hip surgery can be reconstructed with impacted morselized bone grafts. Rinsing these trabecular allografts may enhance graft incorporation by washing out immunogenic factors present blood, marrow, and fat. However, it has been proposed that impaction of the releases biologically active factors, which provide sufficient activity to stimulate new formation. before could allograft incorporation, but rinsing after diminish process graft. To study effect grafts on...

Objectives The Kaplan-Meier estimation is widely used in orthopedics to calculate the probability of revision surgery. Using data from a long-term follow-up study, we aimed assess amount bias introduced by estimator competing risk setting. Methods We describe both and model, explain why model more appropriate approach estimate surgery when patients die hip cohort. In our total 62 acetabular revisions were performed. After mean 25 years, no lost follow-up, 13 had undergone 33 died causes...