A5050241095- Catalytic Processes in Materials Science
- Catalysis and Oxidation Reactions
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Nonlinear Dynamics and Pattern Formation
- Genetic Neurodegenerative Diseases
- Catalysts for Methane Reforming
- Viral-associated cancers and disorders
- Organometallic Complex Synthesis and Catalysis
- Carbon dioxide utilization in catalysis
- Cancer Cells and Metastasis
- Mitochondrial Function and Pathology
- Lung Cancer Treatments and Mutations
- Glioma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Polymer crystallization and properties
- Catalysis and Hydrodesulfurization Studies
- Hemoglobinopathies and Related Disorders
- Chronic Lymphocytic Leukemia Research
- Synthetic Organic Chemistry Methods
- Neurological disorders and treatments
- Cytomegalovirus and herpesvirus research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Liver Disease Diagnosis and Treatment
Children's Hospital of Philadelphia
2014-2024
National Measurement Institute
2024
Bexar County Medical Examiner's Office
2023
Brooke Army Medical Center
2012-2022
Wilford Hall Ambulatory Surgical Center
2018-2022
Joint Base San Antonio
2015-2022
John Wiley & Sons (United States)
2020-2021
San Antonio Uniformed Services Health Education Consortium
2013-2021
Ingham Institute
2016-2021
Western Sydney University
2016-2021
Despite known low sensitivity, culture of periprosthetic tissue specimens on agars and in broths is routine. Culture samples blood bottles (BCBs) potentially more convenient, but it has been evaluated a limited way not widely adopted. The aim this study was to compare the sensitivity specificity inoculation into with standard agar thioglycolate broth culture, applying Bayesian latent class modeling (LCM) addition Infectious Diseases Society America (IDSA) criteria for prosthetic joint...
Androgen receptor splice variant V7 (AR-V7) was recently identified as a valuable predictive biomarker in metastatic castrate-resistant prostate cancer. Here, we report new, sensitive and accurate screen for AR-V7 mRNA expression directly from circulating tumor cells (CTCs): We combined EpCAM-based immunomagnetic CTC isolation using the IsoFlux microfluidic platform with droplet digital polymerase chain reaction (ddPCR) to analyze total AR cancer patients CTCs. demonstrate that is reliably...
Epithelial cell adhesion molecule (EpCAM)-targeted capture remains the most common isolation strategy for circulating tumor cells (CTCs). However, epithelial-to-mesenchymal transition (EMT) leads to decreased epithelial EpCAM expression affecting optimal CTC capture. In this study, we tested a cohort of ovarian cancer lines using flow cytometry identify N-cadherin as additional immunomagnetic surface target isolation. Combined targeting mesenchymal and enriched CTCs from advanced patient...
Background Gene mutation analysis from plasma circulating tumor DNA (ctDNA) can provide timely information regarding the mechanism of resistance that could translate to personalised treatment. We compared concordance rate next generation sequencing (NGS) and droplet digital polymerase chain reaction (ddPCR) in detection EGFR activating T790M ctDNA with diagnostic tissue biopsy‐based assays. The second objective was test whether putative osimertinib associated mutations were detectable using...
Increasing sophistication in the design and application of biological models as well advent novel fluorescent probes have led to new demands on molecular imaging systems deliver enhanced sensitivity, reliable quantitation, ability resolve multiple simultaneous signals. Sensitivity is limited, especially visible spectral range, by presence ubiquitous autofluorescence signals (mostly arising from skin gut), which need be separated those targeted fluorophores. Fluorescence-based also affected...
Main text Nucleic acid amplification tests for SARS-CoV-2, the virus responsible COVID-19 pandemic, primarily target RNA as analyte. These detect presence of SARS-CoV-2 specific sequences, confirming infection through in vitro diagnostic methods. However, lack a standardized reference measurement system has led to varied units and unclear traceability reporting content quantities, complicating comparisons between different [1-5]. To address this challenge, pilot study CCQM-P199b was...
A new technique for characterization of linear low-density polyethylene (LLDPE) is presented in this report. The molecular structure two commercial LLDPEs, produced by copolymerization ethylene with 1-butene over a Ziegler-Natta and metallocene catalyst, was investigated. LLDPE resins were fractionated temperature rising elution fractionation (TREF), the TREF fractions further analyzed size exclusion chromatography differential scanning calorimetry (DSC) coupled successive...
In vivo fluorescence cancer imaging is an important tool in understanding tumor growth and therapeutic monitoring can be performed either with endogenously produced fluorescent proteins or exogenously introduced probes bound to targeting molecules. However, endogenous cannot altered after transfection, thus requiring rederivation of cell lines for each desired color, while targeted are limited by the heterogeneous expression naturally occurring cellular targets. this study, we adapted...
Epstein–Barr virus is a human gammaherpesvirus that infects and establishes latency in B lymphocytes vivo . The latent membrane protein 2 (LMP2) gene expressed latently infected cells encodes two isoforms, LMP2A LMP2B, are identical except for an additional N-terminal 119 aa cytoplasmic domain which present the isoform. A panel of fusion proteins was constructed fluorescent enhanced green DsRed domains were fused to N- C-termini LMP2B. By fluorescence microscopy, LMP2B localized perinuclear...
Abstract The activities of two ( n ‐BuCp) 2 ZrCl catalysts supported on methylaluminoxane (MAO)‐treated polymer particles were evaluated. supports spherical polymeric particles, containing macropores and prepared by suspension polymerization 2‐hydroxyethyl methacrylate, divinyl benzene, ethyl styrene, styrene. Both had a Zr content 0.31 mass % an Al/Zr ratio 185; the for one contained 59 whereas support other catalyst methacrylate 10 %. Ethylene homo‐ ethylene/1‐hexene copolymerization...
Pre- and post-operative neutrophil to lymphocyte ratio (NLR) prognostic nutritional index (PNI) other clinicopathological variables were correlated with progression free survival (PFS) overall (OS) of Glioblastoma Multiforme (GBM) patients.GBM patients (n = 87, single-centre, recruited 2013-2019) retrospectively divided into low high groups using literature-derived cut-offs (NLR 5.07, PNI 46.97). Kaplan-Meier curves log rank tests assessed PFS OS. Univariate multivariate analyses identified...
Introduction Drug development for neurodegenerative diseases such as Friedreich’s ataxia (FRDA) is limited by a lack of validated, sensitive biomarkers pharmacodynamic response in affected tissue and disease progression. Studies employing neuroimaging measures to track FRDA have thus far been their small sample sizes follow up. TRACK-FA, longitudinal, multi-site, multi-modal natural history study, aims address these shortcomings enabling better understanding underlying pathology identifying...
A new method is proposed to determine the power-law order of gas-phase ethylene homopolymerization rate with time-varying activities over morphology-controlled prepolymerized catalyst at temperatures 30−70 °C and concentrations 120−900 mol/m3. The was obtained by prepolymerization mild conditions in heptane using a catalyst, which TiCl4 supported on spherical MgCl2 prepared melt quenching MgCl2−ethanol complex. Triethylaluminum used as cocatalyst for homopolymerization. During...