Omar Mehkri
A5038715780- COVID-19 Clinical Research Studies
- Respiratory Support and Mechanisms
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Intensive Care Unit Cognitive Disorders
- Sepsis Diagnosis and Treatment
- COVID-19 and healthcare impacts
- Vaccine Coverage and Hesitancy
- Acute Kidney Injury Research
- Cardiac Arrest and Resuscitation
- Thermal Regulation in Medicine
- Mechanical Circulatory Support Devices
- COVID-19 Impact on Reproduction
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Ultrasound in Clinical Applications
- Family and Patient Care in Intensive Care Units
- COVID-19 diagnosis using AI
- Pleural and Pulmonary Diseases
- Acute Myeloid Leukemia Research
- COVID-19 and Mental Health
- Pharmacological Receptor Mechanisms and Effects
- SARS-CoV-2 detection and testing
- Emergency and Acute Care Studies
- Poxvirus research and outbreaks
- Inflammatory Biomarkers in Disease Prognosis
National Heart Lung and Blood Institute
2024
Association Clinique et Thérapeutique Infantile du Val de Marne
2023-2024
Cleveland Clinic
2019-2024
St. James's Hospital
2024
George Washington University
2023
University of Colorado Anschutz Medical Campus
2022
University of Alabama at Birmingham
2022
Society of Critical Care Medicine
2021
Prince Charles Hospital
2021
<h3>Importance</h3> Experimental data suggest that intravenous vitamin C may attenuate inflammation and vascular injury associated with sepsis acute respiratory distress syndrome (ARDS). <h3>Objective</h3> To determine the effect of infusion on organ failure scores biological markers in patients ARDS. <h3>Design, Setting, Participants</h3> The CITRIS-ALI trial was a randomized, double-blind, placebo-controlled, multicenter conducted 7 medical intensive care units United States, enrolling (N...
Data are not complete for all characteristics in the table; denominators
Real-world evaluations have demonstrated high effectiveness of vaccines against COVID-19-associated hospitalizations (1-4) measured shortly after vaccination; longer follow-up is needed to assess durability protection. In an evaluation at 21 hospitals in 18 states, the duration mRNA vaccine (Pfizer-BioNTech or Moderna) (VE) was assessed among adults aged ≥18 years. Among 3,089 hospitalized (including 1,194 COVID-19 case-patients and 1,895 non-COVID-19 control-patients), median age 59 years,...
Acute kidney injury (AKI) is the most frequent extra-pulmonary organ failure in acute respiratory distress syndrome (ARDS). The objective of this study was to assess factors associated with development and severity AKI patients ARDS. This a retrospective cohort ARDS without or chronic disease prior onset over 7-year period (2010–2017). were defined according Kidney Disease Improving Global Outcomes 2012 guidelines. Of 634 patients, 357 met criteria. A total 244 (68.3%) developed after onset:...
COVID-19 mRNA vaccines (BNT162b2 [Pfizer-BioNTech] and mRNA-1273 [Moderna]) provide protection against infection with SARS-CoV-2, the virus that causes COVID-19, are highly effective COVID-19-associated hospitalization among eligible persons who receive 2 doses (1,2). However, vaccine effectiveness (VE) immunocompromising conditions* is lower than immunocompetent (2), VE declines after several months all (3). On August 12, 2021, Food Drug Administration (FDA) issued an emergency use...
The SARS-CoV-2 Omicron variant (B.1.1.529 or BA.1) became predominant in the United States by late December 2021 (1). BA.1 has since been replaced emerging lineages BA.2 (including BA.2.12.1) March 2022, followed BA.4 and BA.5, which have accounted for a majority of infections June 2022 Data on effectiveness monovalent mRNA COVID-19 vaccines against BA.4/BA.5-associated hospitalizations are limited, their interpretation is complicated waning vaccine-induced immunity (2-5). Further, with...
Abstract Introduction Understanding the changing epidemiology of adults hospitalized with coronavirus disease 2019 (COVID-19) informs research priorities and public health policies. Methods Among (≥18 years) laboratory-confirmed, acute COVID-19 between 11 March 2021, 31 August 2022 at 21 hospitals in 18 states, those during severe respiratory syndrome 2 (SARS-CoV-2) Omicron-predominant period (BA.1, BA.2, BA.4/BA.5) were compared to from earlier Alpha- Delta-predominant periods. Demographic...
Influenza circulation during the 2022-2023 season in United States largely returned to pre-coronavirus disease 2019 (COVID-19)-pandemic patterns and levels. A(H3N2) viruses were detected most frequently this season, predominately clade 3C.2a1b.2a, a close antigenic match vaccine strain.
Abstract Background Heterogeneous respiratory system static compliance ( C RS ) values and levels of hypoxemia in patients with novel coronavirus disease (COVID-19) requiring mechanical ventilation have been reported previous small-case series or studies conducted at a national level. Methods We designed retrospective observational cohort study rapid data gathering from the international COVID-19 Critical Care Consortium to comprehensively describe —calculated as: tidal volume/[airway...
Abstract Background The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate COVID-19 patients with moderate-to-severe ARDS the impact early use NMBAs on 90-day mortality, through propensity score (PS) matching analysis. Methods We analyzed a convenience sample and ARDS, admitted 244 intensive care units within Critical Care Consortium, from February 1, 2020,...
The neutrophil-lymphocyte ratio is an inexpensive and simple inflammatory marker. A higher ratio, indicative of acute hyperinflammatory response or diminished overall physiologic health status, has been associated with poor prognoses. This study aimed to evaluate the prognostic potential admission in patients admitted medical ICU coronavirus disease 2019.Retrospective review prospectively collected data.Medical from a large center.2,071 consecutive laboratory-confirmed severe respiratory...
The primary objective was to evaluate ICU mortality at 28 days in patients with severe hypoxemic respiratory failure due coronavirus disease 2019 infection who received tocilizumab. secondary objectives were ICU-, hospital-, mechanical ventilation-, and vasopressor-free day development of infections.Retrospective, observational, multicenter, cohort study between March 15, 2020, May 31, 2020. Using propensity score matching based on admission source, C-reactive protein, Sequential Organ...
Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% vaccinated), VE 96% (95% confidence interval [CI], 93%-98%) patients with no chronic medical conditions 83% CI, 76%-88%) ≥ 3 categories of conditions. similar between those aged 18-64 years versus ≥65 (P > .05). severe very high...
Coronavirus disease 2019 (COVID-19) vaccine effectiveness (VE) studies are increasingly reporting relative VE (rVE) comparing a primary series plus booster doses with only. Interpretation of rVE differs from traditional measuring absolute (aVE) regimen against an unvaccinated referent group. We estimated aVE and COVID-19 hospitalization in primary-series first-booster recipients vaccines.Booster-eligible immunocompetent adults hospitalized at 21 medical centers the United States during...
Acute kidney injury (AKI) is the most common extra-pulmonary organ failure in acute respiratory distress syndrome (ARDS). Renal recovery after AKI determined by several factors. The objective of this study was to determine predictors renal non-recovery ARDS patients.A single center retrospective cohort patients with onset ARDS. Patients preexisting chronic disease or intensive care unit stay < 24 h were excluded. staging defined according Kidney Disease Improving Global Outcomes (KDIGO) 2012...
Abstract Septic shock is associated with over 40% mortality. The immune response in septic tightly regulated by cellular metabolism and transitions from early hyper-inflammation to later hypo-inflammation. Patients are susceptible secondary infections during magnitude of the metabolic dysregulation effect plasma metabolites on circulating cells not reported. We hypothesized that accumulated affect Our study took a unique approach. Using peripheral blood adult patients healthy controls, we...
Treatments for ARDS that improve patient outcomes include use of lung-protective ventilation, prone and conservative fluid management. Implementation protocols via educational programs might adherence outcomes. The objective this study was to investigate the effects an protocol implementation on with guidelines.This a single-center, interventional, comparative before after implementation. Staff education implemented between June 2014 May 2015. A retrospective cohort analysis conducted during...
Rescue treatments for status asthmaticus remain limited. Current literature has mainly focused on using extracorporeal membrane oxygenation (ECMO) as a primary modality of care these patients. Low-flow CO 2 removal (ECCO R) systems are an attractive option to improve refractory hypercapnic respiratory acidosis because asthmaticus. This is retrospective case series that describes the feasibility and efficacy use low-flow ECCO R device, Hemolung Respiratory Assist System, in patients with...