A5048972543- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Obesity and Health Practices
- Genetics and Neurodevelopmental Disorders
- Palliative Care and End-of-Life Issues
- Cardiac Structural Anomalies and Repair
- Medical Education and Admissions
- Diversity and Career in Medicine
- Neurogenesis and neuroplasticity mechanisms
- LGBTQ Health, Identity, and Policy
- Autism Spectrum Disorder Research
- Innovations in Medical Education
- Emergency and Acute Care Studies
- COVID-19 and healthcare impacts
- Diabetes Management and Research
- Cardiac Valve Diseases and Treatments
- Cardiac tumors and thrombi
- Sexuality, Behavior, and Technology
- Cannabis and Cannabinoid Research
Cleveland Clinic Lerner College of Medicine
2021-2025
Case Western Reserve University
2017-2023
Cleveland Clinic
2022
Introduction: Growing research on adult development recognises socioeconomically adverse neighbourhood environments as sources of stress affecting immunohaematologic function (IHF), with implications for disease. However, little is known about IHF markers in youth across diverse neighbourhoods. One marker IHF, red blood cell distribution width (RDW), has demonstrated prognostic value multiple diseases the life course. Methods: This retrospective cohort study analysed data from 771 well-child...
Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by loss-of-function mutations in the gene encoding methyl-CpG-binding protein 2 (MeCP2; Amir et al., 1999), transcriptional regulatory (Klose 2005). Mouse models of RTT (Mecp2 mutants) exhibit excitatory hypoconnectivity medial prefrontal cortex (mPFC; Sceniak 2015), region critical for functions that are abnormal patients, ranging from learning and memory to regulation visceral homeostasis (Riga 2014). The present study was...
Healthcare systems and providers have increasingly acknowledged the role impact of social determinants in overall health. However, gender-diverse individuals face persistent health disparities due to their identities. There is limited research on clinical sociodemographic characteristics mood quality life (QoL) for transgender (TG) individuals. Our study aims understand better elucidate transmasculine (TM) transfeminine (TF) depressive symptoms. In this cross-sectional study, 298 TF TM...
Abstract Context Total pancreatectomy with islet autotransplantation (TPIAT) is a definitive management for intractable pain in patients chronic pancreatitis (CP). Islet (IAT) allows the preservation of beta cells to prevent complications long-term diabetes. Objective Our study follows TPIAT recipients up 12 years determine efficacy procedure completed an off-site isolation facility. Methods Patient demographics, mixed meal tolerance test measures, glycosylated hemoglobin, insulin...
The inflammatory response is an obstacle to success in both allogeneic and autologous islet transplantation. In transplantation (AIT), however, the recipient also donor, permitting pretreatment of donor/recipient for a controlled duration prior We sought exploit this feature (AIT) by pretreating donor/recipients with chronic pancreatitis undergoing total pancreatectomy (TPAIT) test hypothesis that peri-transplant treatment FDA-approved anti-inflammatory hydroxychloroquine (HCQ) improves...
Context: Total pancreatectomy (TP) with islet-cell auto transplantation (IAT) is an option for pain management patients chronic pancreatitis (CP). IAT allows the preservation of beta cell function to reduce or prevent long-term diabetes. Objective: We performed a follow-up study up 12 years after TPIAT surgery off-site isolation laboratory, determine efficacy and durability procedure. Methods: Data (August 2008 August 2020) were obtained from database which included information medical...