A5016984575- Sepsis Diagnosis and Treatment
- Machine Learning in Healthcare
- Hemodynamic Monitoring and Therapy
- Biomedical Text Mining and Ontologies
- Topic Modeling
- Nanoparticle-Based Drug Delivery
- Trauma and Emergency Care Studies
- Erythrocyte Function and Pathophysiology
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Hepatocellular Carcinoma Treatment and Prognosis
- MRI in cancer diagnosis
- Cardiac, Anesthesia and Surgical Outcomes
- Jewish and Middle Eastern Studies
- Chinese history and philosophy
- Blood disorders and treatments
- Emergency and Acute Care Studies
- Nanoplatforms for cancer theranostics
- SARS-CoV-2 and COVID-19 Research
- Ultrasound and Hyperthermia Applications
- Politics and Conflicts in Afghanistan, Pakistan, and Middle East
- Erythropoietin and Anemia Treatment
- Electronic Health Records Systems
- Innovations in Medical Education
- COVID-19 Clinical Research Studies
- Vaccine Coverage and Hesitancy
Agios Pharmaceuticals (United States)
2022
Beth Israel Deaconess Medical Center
2015-2021
University of Southern Denmark
2021
Hadassah Medical Center
2019
Massachusetts Institute of Technology
2017-2018
National Institutes of Health
2018
University of British Columbia
2018
Northwestern University
2010-2016
Harvard University
2016
Northwestern Memorial Hospital
2015
Real-world evaluations have demonstrated high effectiveness of vaccines against COVID-19-associated hospitalizations (1-4) measured shortly after vaccination; longer follow-up is needed to assess durability protection. In an evaluation at 21 hospitals in 18 states, the duration mRNA vaccine (Pfizer-BioNTech or Moderna) (VE) was assessed among adults aged ≥18 years. Among 3,089 hospitalized (including 1,194 COVID-19 case-patients and 1,895 non-COVID-19 control-patients), median age 59 years,...
In secondary analysis of electronic health records, a crucial task consists in correctly identifying the patient cohort under investigation. many cases, most valuable and relevant information for an accurate classification medical conditions exist only clinical narratives. Therefore, it is necessary to use natural language processing (NLP) techniques extract evaluate these The commonly used approach this problem relies on extracting number clinician-defined concepts from text using machine...
Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury. Preclinical models suggest that fluid resuscitation degrades the glycocalyx, a heparan sulfate-enriched structure necessary for vascular homeostasis. We hypothesized glycocalyx degradation is associated with volume intravenous fluids administered during early resuscitation.We used mass spectrometry to measure plasma sulfate (a highly sensitive and specific...
Aim: NanoKnife® (Angiodynamics, Inc., NY, USA) or irreversible electroporation (IRE) is a newly available ablation technique to induce the formation of nanoscale pores within cell membrane in targeted tissues. The purpose this study was elucidate morphological alterations following 30 min IRE mouse model pancreatic cancer. Materials & methods: Immunohistochemistry markers were compared with diffusion-weighted MRI apparent diffusion coefficient measurements before and after ablation. Results:...
Nanoparticles (NP) have emerged as a novel class of therapeutic agents that overcome many the limitations current cancer chemotherapeutics. However, major challenge to NP platforms is unfavorable biodistribution, and limited tumor uptake, upon systemic delivery. Delivery, therefore, remains critical barrier widespread clinical adoption therapeutics. To these limitations, we adapted techniques image-guided local drug delivery develop nanoablation nanoembolization. Nanoablation ablative...
Objectives: Interhospital transfer, a common intervention, may be subject to healthcare disparities. In mechanically ventilated patients with sepsis, we hypothesize that disparities not disease related would found between who were and transferred. Design: Retrospective cohort study. Setting: Nationwide Inpatient Sample, 2006–2012. Patients: Patients over 18 years old primary diagnosis of sepsis underwent mechanical ventilation. Interventions: None. Measurements Main Results: We obtained age,...
Abstract The majority of salivary stones are less than 8 mm in size and most frequently occur the submandibular gland. Traditional management larger involves gland resection. Sialendoscopy combined with an external or a transoral sialolithotomy, also called approach technique, permits stone removal preservation. A 31‐year‐old male presented to our service 20‐mm megalith left Here we report first description using da Vinci Si Surgical System facilitate duct repair. Laryngoscope, 2011
The outcomes of critically ill patients who undergo interhospital transfer are not well understood. Physicians assume that will receive more advanced care may translate into decreased morbidity or mortality relative to a similar patient is transferred. However, there little empirical evidence support this assumption. We examined country-level U.S. data from the Nationwide Readmissions Database examine whether, in mechanically ventilated with sepsis, associated benefit.
Laboratory data are frequently collected throughout the care of critically ill patients. Currently, these interpreted by comparison with values from healthy outpatient volunteers. Whether this is most useful has yet to be demonstrated.To understand how distribution intensive unit (ICU) laboratory differs reference range, and distributions related patient outcomes.Cross-sectional study a large critical database, Medical Information Mart for Intensive Care January 1, 2001, October 31, 2012....
* Prologue: The Risk of War Taiwan Crisis Sino-Soviet Border: 1969 Nixon: Opening Ford: Estrangement-I smile bitterly Carter: Fulfillment-The president has made up his mind Reagan and Bush Tiananmen Clinton: Butchers Beijing
Medical students are increasingly using electronic health records (EHRs) in clerkships, and medical educators should seek opportunities to use this new technology improve training. One such opportunity is the ability "track" former patients EHR, defined as following up on EHR for educational purposes a period of time after they have left one's direct care. This activity offers great promise clinical training by enabling audit their diagnostic impressions follow history illness manner not...
Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% vaccinated), VE 96% (95% confidence interval [CI], 93%-98%) patients with no chronic medical conditions 83% CI, 76%-88%) ≥ 3 categories of conditions. similar between those aged 18-64 years versus ≥65 (P > .05). severe very high...
Abstract Objective In septic patients, multiple retrospective studies show an association between large volumes of fluids administered in the first 24 h and mortality, suggesting a benefit to fluid restrictive strategies. However, these do not directly estimate causal effects fluid-restrictive strategies, nor their analyses properly adjust for time-varying confounding by indication. this study, we used inference techniques mortality outcomes that would result from imposing range arbitrary...
Purpose Surgical resection of colorectal liver metastases is not achievable in more than 70% the cases. Although directed therapies have become a part stand care, lack preclinical model impedes assessment toxicity and therapeutic benefits attributed several candidate drugs or treatment regimens that can be designed. In present study we aim develop characterize rat metastasis model. Materials Methods Growth characteristics CC-531 cells were determined vitro followed by subcapsular...
Objective: We investigate whether deep learning techniques for natural language processing (NLP) can be used efficiently patient phenotyping. Patient phenotyping is a classification task determining has medical condition, and crucial part of secondary analysis healthcare data. assess the performance algorithms compare them with classical NLP approaches. Materials Methods: convolutional neural networks (CNNs), n-gram models, approaches based on cTAKES that extract pre-defined concepts from...
Background Understanding factors that drive admissions is critical to containing cost and optimising hospital operations. We hypothesised that, due multiple factors, emergency physicians would be more likely admit a patient seen later in their shift. Methods Retrospective study examining all visits at large academic from July 2010 2016. Patients with missing data (n=191) were excluded. 294 031 department (ED) included the final analysis. The exposure of interest was time during shift which...