A5103275261- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Lung Cancer Research Studies
- Immunotherapy and Immune Responses
- Cutaneous Melanoma Detection and Management
- Head and Neck Surgical Oncology
- Immunodeficiency and Autoimmune Disorders
- Oral and Maxillofacial Pathology
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Neuroendocrine Tumor Research Advances
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Ear Surgery and Otitis Media
- Melanoma and MAPK Pathways
- Brain Metastases and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Anomalies
- Ear and Head Tumors
- Colorectal Cancer Treatments and Studies
- Vestibular and auditory disorders
- Occupational and environmental lung diseases
- Cancer Diagnosis and Treatment
- Advanced Biosensing Techniques and Applications
ACT Government
2020-2024
Australian National University
2020-2024
Canberra Hospital
2019-2024
Act Health
2022
Princess Alexandra Hospital
2017-2020
Olivia Newton-John Cancer Wellness & Research Centre
2017-2018
Royal Brisbane and Women's Hospital
2016
Prince Charles Hospital
2016
Redcliffe Hospital
2015
The University of Queensland
2015
Abstract The majority of salivary stones are less than 8 mm in size and most frequently occur the submandibular gland. Traditional management larger involves gland resection. Sialendoscopy combined with an external or a transoral sialolithotomy, also called approach technique, permits stone removal preservation. A 31‐year‐old male presented to our service 20‐mm megalith left Here we report first description using da Vinci Si Surgical System facilitate duct repair. Laryngoscope, 2011
To describe the management of bilateral oral ranulas with use da Vinci Si Surgical System and discuss advantages disadvantages over traditional transoral resection. Case Report Review Literature. A 47 year old woman presented to our service an obvious right floor mouth swelling. Clinical evaluation computerized tomography scan confirmed a large ranula on incidental asymptomatic early left sublingual gland. After obtaining informed consent, patient underwent robotic-assisted excision gland...
Abstract As chronic antigenic stimulation from infection and autoimmunity is a feature of primary antibody deficiency (PAD), analysis affected patients could yield insights into T-cell differentiation explain how environmental exposures modify clinical phenotypes conferred by single-gene defects. CD57 marks dysfunctional T cells that have differentiated after stimulation. Indeed, while circulating + CD4 are normally rare, we found they increased in with PAD markedly CTLA4 haploinsufficiency...
To present a case of mucosal melanoma the Eustachian tube with focus on surgical technique and to review literature treatment head neck, cases involving middle ear and/or tube.A 67-year-old man was diagnosed tube.The patient underwent primary resection including transtemporal/transpetrosal approach, endoscopic nasopharyngectomy, infratemporal fossa dissection, temporomandibular joint resection, ipsilateral neck dissection (levels II-IV), superficial parotidectomy.The discharged postoperative...
Wider use of chemotherapy and targeted agents can be associated with posterior reversible encephalopathy syndrome (PRES). This is most commonly found in metastatic adenocarcinoma treated platinum-based analogs managed cessation the precipitating medication. We present first case PRES early-stage breast cancer discuss further management this condition. Recognition condition correction identifiable factor including relevant medications remains important its management.
Abstract Objective: This study aimed to assess the feasibility of using a 1.3 mm, semi-rigid, interventional salivary endoscope for middle-ear endoscopy, and as trans-tympanic route delivery medication, in human cadaveric temporal bones. Study design: Human study. Methods: Five bones harvested from cadavers were examined. A sialendoscope was used make endoscopy-assisted myringotomy incisions postero-inferior quadrant ( n = 5) antero-inferior 3). Results: Middle-ear examination successful all...
Nasopharyngeal papillomatosis is uncommon. Access and visualization make excision difficult, increasing the risk for recurrence. We present a novel technique of nasopharyngeal papillomatosis.A case series 3 patients with recurrent papilloma nasopharynx (NP) were treated endoscopic transnasal coblation. used an Arthrocare EVac 70 Coblator (setting: coblation-9, coagulation-5).Using coblation, we performed complete in NP (4 total procedures). There no complications. One patient had minor...
While studies continually identify new clinical prognostic factors in stage IV melanoma, the introduction of targeted and immunotherapies have revolutionised prognosis advanced melanoma since 2011. The study aims to investigate significance past newly identified a contemporary cohort.A retrospective analysis Canberra Hospital database 161 patients with Stage between 2011 2017. Survival was analysed by demographics chi-square tests determine significance. Logistic binary regression performed...
While prognosis in metastatic melanoma has traditionally been poor, novel systemic therapies such as immunotherapy and targeted agents have improved overall survival (Steininger et al., 2021). These medications are generally well tolerated but can be associated with immune related adverse events (Remash Hepatic metastatectomy is an important component of management, conferring a benefit over therapy alone appropriately selected patients (Medina 2020). Gadoxetic acid-enhanced magnetic...
Metastasis of non-gastrointestinal (non-GI) cancers to the upper GI tract is a rare occurrence, with limited cases reported in literature. Recognising this type metastasis crucial, as it presents unique diagnostic and therapeutic challenges. This case series adds literature by discussing seven non-GI cancer metastasising tract, emphasising complications clinical manifestations. These highlight importance early recognition interdisciplinary management optimise patient outcomes. retrospective...
10049 Background: Patients with advanced melanoma who progress on 1 st line TT and 2 nd IT have limited treatment options. We explored the safety efficacy of re-treatment 3 rd TT. Methods: was pooled from 6 centers in Australia 2009-2018. Eligible patients BRAF V600 mutant had therapy a BRAF/MEK inhibitor, IO were re-challenged inhibitor. Results: 90 included; median age 61 years, 78% V600E, 89% ECOG 0-1 at baseline. combination inhibitors 80%, predominately dabrafenib/trametinib. Response...
Abstract As chronic antigenic stimulation from infection and autoimmunity are features of primary antibody deficiency (PAD), analysis affected patients could yield insights into T cell differentiation, explain how environmental exposures modify clinical phenotypes conferred by single gene defects. CD57 marks dysfunctional cells that have differentiated after stimulation. Indeed, while + CD4 normally rare in the circulation, we found they increased with PAD, markedly CTLA4 haploinsufficiency...
The aim of our study was to assess feasibility using a 1.3mm semi-rigid interventional salivary endoscope for middle ear endoscopy and as route trans-tympanic delivery medication in human cadaveric temporal bones.Five bones harvested from cadavers were examined. A diameter 0 degree. Marchal sialendoscope equipped with an channel (0.4 mm) irrigation/suction used. Middle performed via endoscopic guided postero-inferior antero-superior myringotomies. round window niche (RWN) easily identified,...
Intracranial metastases occur in 30–50% of patients with Non-small cell lung cancer (NSCLC) and have a poor prognosis despite current therapies utilising systemic chemotherapy, neurosurgery radiotherapy. In contrast to the robust evidence for using immunotherapy treat intracranial melanoma, responses NSCLC are limited retrospective studies case reports describing third-line treatment. These describe durable, complete, cerebral leptomeningeal first-line pembrolizumab highly-selected...
9571 Background: Adjuvant anti-PD1 therapy reduces the risk of recurrence in resected stage III/IV melanoma and is now standard care. Limited data exist beyond registration trials. We sought to explore use adjuvant immunotherapy routine clinical practice. Methods: Patients (pts) from 11 Australian centres who received nivolumab (nivo) for were included this study. Efficacy, toxicity, surveillance, characteristics, management further treatment outcomes examined. Results: 471 pts nivo between...
6589 Background: As CC becomes increasingly complex clinicians face the challenge of meeting patients’ holistic care needs within limited time. Moreover, inefficient information technology systems (ITS) and multiple OST can impact upon time spent on direct CC. We explored quantity in OOEs. Methods: Two separate focus groups were conducted at a tertiary institution with oncology specialists (5) trainees to explore scope required each OOE. Content analysis was performed define: Core,...
2514 Background: Melanomas and lung cancers usually display a large burden of somatically mutated proteins, yet only subset individuals can be induced to mount therapeutic immune response against tumours. Inherited mutations in regulatory genes may one factor predisposing heightened with addition an stimulus. Methods: Germline whole genome sequencing (WGS) was performed patient exceptional (ExR) targeted radiotherapy for metastatic melanoma (complete abscopal response). A target variant gene...