A5069691001- Acute Ischemic Stroke Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Intensive Care Unit Cognitive Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Arrest and Resuscitation
- Cerebrovascular and Carotid Artery Diseases
- Mechanical Circulatory Support Devices
- Long-Term Effects of COVID-19
- Respiratory Support and Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Stroke Rehabilitation and Recovery
- Acute Kidney Injury Research
- Global Health and Surgery
- Atrial Fibrillation Management and Outcomes
- Biomedical and Engineering Education
- Cerebrospinal fluid and hydrocephalus
- Surgical Simulation and Training
- Cardiac, Anesthesia and Surgical Outcomes
- Simulation-Based Education in Healthcare
- Autoimmune Neurological Disorders and Treatments
- Cardiovascular Effects of Exercise
- RNA regulation and disease
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular and Diving-Related Complications
- Vagus Nerve Stimulation Research
Johns Hopkins Medicine
2018-2024
Johns Hopkins University
2018-2024
University of South Dakota
2021-2024
Avera McKennan Hospital & University Health Center
2021-2023
Avera Health
2020-2021
McMaster University
2018
University of Massachusetts Chan Medical School
2014-2017
American University of Beirut
2012
Optimal neurologic monitoring methods have not been characterized for patients on extracorporeal membrane oxygenation (ECMO). We assessed the feasibility of noninvasive multimodal neuromonitoring (NMN) to prognosticate outcome. In this prospective observational study, examinations, transcranial Doppler (TCD), electroencephalography (EEG), and somatosensory evoked potentials (SSEPs) were performed at prespecified intervals. Outcome discharge was defined as favorable when modified Rankin Scale...
Objective High white matter hyperintensity (WMH) burden is commonly found on brain MRI among patients with atrial fibrillation (AF). However, whether the link between AF and WMH extends beyond a common vascular risk factor profile uncertain. We sought to determine relates distinct lesion pattern which may suggest specific underlying pathophysiological relationships. Methods retrospectively analysed cohort of consecutive presenting embolic stroke at an academic hospital tertiary referral...
Small subcortical infarcts (SSI) frequently coexist with brain white matter hyperintensity (WMH) lesions. We sought to determine whether preexisting WMH burden relates SSI volume, etiology, and 90-day functional outcome.We retrospectively studied 80 consecutive patients acute SSI. Infarct volume was determined on diffusion weighted imaging, graded fluid-attenuated inversion recovery sequences according the Fazekas scale. etiology categorized as small vessel disease (SVD) vs non-SVD related....
Abstract Background The role of neuromuscular blocking agents (NMBAs) in coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (ARDS) is not fully elucidated. Therefore, we aimed to investigate COVID-19 patients with moderate-to-severe ARDS the impact early use NMBAs on 90-day mortality, through propensity score (PS) matching analysis. Methods We analyzed a convenience sample and ARDS, admitted 244 intensive care units within Critical Care Consortium, from February 1, 2020,...
Intracerebral hemorrhage (ICH) results in a cascade of inflammatory cell activation with recruitment peripheral leukocytes to the brain parenchyma and surrounding hematoma. We hypothesized that patients ICH intraventricular (IVH), robust cerebrospinal fluid (CSF) response occurs leukocyte subtypes being affected by alteplase treatment contributing outcomes.Serum CSF counts from phase 3 Clot Lysis: Evaluating Accelerated Resolution Intraventricular Hemorrhage (CLEAR III) trial were analyzed....
To describe a case of leucine-rich glioma-inactivated protein 1 (LGI1) antibody-associated encephalitis.The clinical and ancillary data brain MRIs were gathered retrospectively by chart review. Relevant literature on similar cases was also reviewed.The diagnosis LGI1 autoimmune encephalitis based the typical presentation seizures, psychiatric symptoms, memory loss as well negative diagnostic testing for cancer; confirmed positive antibody. The patient responded favorably to treatment with IV...
Prehospital stroke scales may help identify patients likely to have large-vessel occlusion facilitate rapid triage thrombectomy-capable centers. Scale misclassification result in inaccurate decisions and possible harm. Pre-existing leukoaraiosis has been shown attenuate the association between deficit type severity. We sought determine whether affects predictive ability of 5 commonly used scales.We retrospectively analyzed 274 consecutive with available brain MR imaging vessel imaging....
In this COVID-19 Critical Care Consortium (CCCC) sub-study, we qualified neurological complications associated with SARS-CoV2 infection.
Introduction: Ischemic stroke is a major cause of morbidity and mortality. However, the interface various premorbid medical conditions, vascular risk factors prior, prior antithrombotic or statins medication use, in-hospital complications in effecting outcomes not clearly established. We attempt establishing associated with improved after an acute ischemic (AIS). Materials Methods: Using prospectively collected database, University Health Consortium from 1999 to 2004, national USA...
Stroke, a leading cause of morbidity and mortality, remains an active venue for discovery. Advances in stroke neurology include prevention, treatment, detection, addition to rehabilitation. In terms vast strides have been taken since the five major intra-arterial treatment trials, with extension window use imaging better patient selection. Treatment hemorrhagic has also improved past decade understanding pathophysiology disease, establishment guidelines blood pressure control monitoring,...
Chronic lymphocytic leukemia (CLL) rarely results in central nervous system (CNS) involvement. When CLL does affect the CNS, it typically manifests as leptomeningeal involvement, not commonly causing parenchymal involvement unless having undergone a higher grade transformation. We report case of patient with untreated who presented large right frontal hemorrhagic mass along additional bilateral masses after being found unresponsive. He had recently been hospitalized Staphylococcus aureus...