A5036526711- Sepsis Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Cardiac Arrest and Resuscitation
- Respiratory Support and Mechanisms
- Intensive Care Unit Cognitive Disorders
- COVID-19 Clinical Research Studies
- Emergency and Acute Care Studies
- Family and Patient Care in Intensive Care Units
- Hemodynamic Monitoring and Therapy
- Vitamin K Research Studies
- Palliative Care and End-of-Life Issues
- COVID-19 and healthcare impacts
- Heparin-Induced Thrombocytopenia and Thrombosis
- Disaster Response and Management
- Antibiotic Use and Resistance
- Acute Kidney Injury Research
- Pleural and Pulmonary Diseases
- Thermal Regulation in Medicine
- Alcoholism and Thiamine Deficiency
- Intramuscular injections and effects
- Hospital Admissions and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Airway Management and Intubation Techniques
- Electronic Health Records Systems
Inova Fairfax Hospital
2023-2025
Virginia Commonwealth University
2015-2023
National Heart Lung and Blood Institute
2023
Pulmonary and Critical Care Associates
2023
Society of Critical Care Medicine
2022
Children's Hospital of Richmond at VCU
2021-2022
Virginia Commonwealth University Medical Center
2018-2020
University Health System
2017-2020
Sinai Hospital
2015
Mayo Clinic
2012-2015
<h3>Importance</h3> Experimental data suggest that intravenous vitamin C may attenuate inflammation and vascular injury associated with sepsis acute respiratory distress syndrome (ARDS). <h3>Objective</h3> To determine the effect of infusion on organ failure scores biological markers in patients ARDS. <h3>Design, Setting, Participants</h3> The CITRIS-ALI trial was a randomized, double-blind, placebo-controlled, multicenter conducted 7 medical intensive care units United States, enrolling (N...
(1) Background: The disease-modifying mechanisms of high-dose intravenous vitamin C (HDIVC) in sepsis induced acute respiratory distress syndrome (ARDS) is unclear. (2) Methods: We performed a post hoc study plasma biomarkers from subjects enrolled the randomized placebo-controlled trial CITRIS-ALI. explored effects HDIVC on cell-free DNA (cfDNA) and syndecan-1, surrogates for neutrophil extracellular trap (NET) formation degradation endothelial glycocalyx, respectively. (3) Results: In 167...
Abstract Background Mechanical power (MP) serves as a crucial predictive indicator for ventilator-induced lung injury and plays pivotal role in tailoring the management of mechanical ventilation. However, its application across different diseases stages remains nuanced. Methods Using AmsterdamUMCdb, we conducted retrospective study to analyze causal relationship between MP outcomes invasive ventilation, specifically SpO 2 /FiO ratio (P/F) ventilator-free days at day 28 (VFD28). We employed...
OBJECTIVES: Early antibiotic administration is a central component of sepsis guidelines, and delays may increase mortality. However, prior studies have examined the delay to first as single time period even though it contains two distinct processes: ordering delivery, which can each be targeted for improvement through different interventions. The objective this study was characterize compare patients who experienced order or delivery delays, investigate association type with mortality,...
There is mounting evidence that delays in appropriate antimicrobial administration are responsible for preventable deaths patients with sepsis. Herein, we examine the association between potentially modifiable delays, measured by time from first order to (antimicrobial lead time), and death among people who present new onset of sepsis.Observational cohort case-control study.The emergency department an academic, tertiary referral center during a 3.5-year period.Adult sepsis or septic...
Readmissions or "bounce back" to the intensive care unit (ICU) following cardiac surgery is associated with an increased risk of morbidity and mortality. We sought identify clinical system-based factors ICU bounce backs in order generate a Bounce Back After Transfer (BATS) prediction score.We prospectively collected financial records all patients undergoing coronary artery bypass grafting (CABG) surgical aortic valve replacement (AVR) between May 2013 March 2014. Multivariable logistic...
Noise is a significant contributor to sleep disruption in the intensive care unit (ICU) that may result increased patient morbidity such as delirium and prolonged length of stay ICU. We conducted pre-post intervention study 24-bed tertiary academic medical ICU reduce mean noise levels. Baseline dosimeter recordings levels demonstrated level 54.2 A-weighted decibels (dBA) peak 109.9 dBA, well above Environmental Protection Agency's recommended There were 1735 episodes "defects" (maximum > 60...