A5103284625- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Sepsis Diagnosis and Treatment
- COVID-19 Clinical Research Studies
- COVID-19 and healthcare impacts
- HIV Research and Treatment
- Antibiotic Resistance in Bacteria
- Pneumocystis jirovecii pneumonia detection and treatment
- Intensive Care Unit Cognitive Disorders
- Ultrasound in Clinical Applications
- Emergency and Acute Care Studies
- Polyomavirus and related diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Mechanical Circulatory Support Devices
- HIV/AIDS drug development and treatment
- Pneumothorax, Barotrauma, Emphysema
- Antibiotic Use and Resistance
- Pleural and Pulmonary Diseases
- Airway Management and Intubation Techniques
- COVID-19 diagnosis using AI
- Advanced oxidation water treatment
- Water Quality Monitoring and Analysis
ASST Fatebenefratelli Sacco
2020-2024
Luigi Sacco Hospital
2020-2023
University of Milan
1993-2021
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2010-2019
University of Milano-Bicocca
2012-2017
Ospedale Maggiore
1996-2009
Vita-Salute San Raffaele University
1999-2003
Office of Infectious Diseases
2003
Hôpital Edouard Herriot
1999
Istituti di Ricovero e Cura a Carattere Scientifico
1996-1999
Aetiology of neurodegenerative mechanisms underlying Alzheimer's disease (AD) are still under elucidation. The contribution cerebrovascular deficiencies (such as cerebral ischemia/stroke) has been strongly endorsed in recent years. Reduction blood supply leading to hypoxic condition is known activate cellular responses mainly controlled by hypoxia-inducible transcription factor-1 (HIF-1). Thus alterations oxygen responsive HIF-1α subunit the central nervous system may contribute cognitive...
Not all risk factors for acquiring multidrug-resistant (MDR) organisms are equivalent in predicting pneumonia caused by resistant pathogens the community. We evaluated MDR bacteria patients coming from community who were hospitalized with pneumonia. Our evaluation was based on actual infection a pathogen and clinical outcome during hospitalization. An observational, prospective study conducted consecutive Data admission hospitalization collected. Logistic regression models used to evaluate...
Case Report A 54 years old woman with COVID-19 related pneumonia presented to our emergency department complaining of scotomas and decreased vision in her right eye. Funduscopic examination multimodal imaging revealed rare retinal hemorrhages, whitening, fern-like hypo-autofluorescent appearance typical iCRVO. She had no risk factors other than a transient hyper-coagulability status likely the ongoing infection. Systemic treatment steroids normalized inflammatory coagulation occlusion...
Cerebrospinal fluid (CSF) samples were examined from 7 patients infected with human immunodeficiency virus type 1 (HIV-1) who had progressive multifocal leukoencephalopathy (PML). Samples obtained both before and after 35–365 days of highly active antiretroviral therapy (HAART). By polymerase chain reaction, JC (JCV) DNA was found in 6 at baseline but only patient HAART. In contrast, 25 historical control whom sequential CSF specimens obtained, no reversion detectable to undetectable JCV...
Acute respiratory failure (ARF) and severe sepsis (SS) are possible complications in patients with community-acquired pneumonia (CAP). The aim of the study was to evaluate prevalence, characteristics, risk factors impact on mortality hospitalized CAP according presence ARF SS admission. This a multicenter, observational, prospective consecutive admitted three hospitals Italy, Spain, Scotland between 2008 2010. Three groups were identified: those neither nor (Group A), only B) both C) Among...
ABSTRACT Sensitive and specific techniques to detect identify Mycobacterium tuberculosis directly in clinical specimens are important for the diagnosis management of patients with (TB). We developed two real-time PCR assays, based on IS 6110 multicopy element senX3 - regX3 intergenic region, which provide a rapid method mycobacterial infections. The sensitivity specificity both assays were established by using purified DNA from 71 isolates 121 samples collected 83 patients, 20 whom affected...
Chlamydophila pneumoniae and Mycoplasma are associated with acute exacerbation of bronchial asthma (AEBA). The aim this study was to evaluate the correlation between these bacterial infections severity AEBA. We prospectively analysed consecutive patients admitted Emergency Department exacerbation. In every patient peak expiratory flow (PEF) measurement performed on admission, spirometry during follow-up. Serology for admission after 4–8 weeks. Fifty-eight completed study. Acute atypical...
To evaluate noninvasive ventilation (NIV) in diffuse interstitial lung diseases (DILD) patients with acute respiratory failure (ARF) according to baseline radiological patterns and the etiology of ARF. In a multicenter, observational, retrospective study, consecutive DILD undergoing NIV because an episode ARF were evaluated six Italian high dependency units. Three groups identified based on ARF: those pneumonia (Group A), exacerbation fibrosis, B) other triggers C). Clinical was defined as...
Although previous studies showed an increasing prevalence of infections due to multi-drug resistant (MDR) bacteria in the community, specific data on sepsis are lacking. We aimed assess prevalence, risk factors and outcomes patients with MDR bacteria.An observational, retrospective study was conducted consecutive adult coming from community admitted Policlinico Hospital, Milan, Italy, a diagnosis between January 2011 December 2015. Primary outcome in-hospital mortality.Among 518 patients, at...
BackgroundHigh diagnostic accuracy for pneumonia, absence of radiation exposure and repeatability are intrinsic features lung ultrasonography making it an attractive tool in the assessment patients with COVID-19 pneumonia. The aim our prospective, observational study was to detect COVID-19-associated sonographic assess potential value LUS predicting adverse events.MethodsFrom March 12th April 20th 2020 admitted two medium-intensive wards a discharge diagnosis pneumonia were enrolled...
Diabetes mellitus was diagnosed in 16 out of 1011 HIV-positive patients over a median follow-up 289 days (person-year incidence 2.06, 95% confidence interval 1.18–3.33). Significant risk factors for the onset diabetes were older age and antiretroviral therapy with stavudine or indinavir. Older men HIV infection should be considered at higher diabetes, caution may warranted use both indinavir these patients. The association between highly active (HAART) metabolism disorders described shortly...
Abstract Background Italy was the first European country hit by COVID-19 pandemic and has highest number of recorded deaths in Europe. Methods This prospective cohort study correlates risk death patients conducted at Infectious Diseases Intensive Care units Luigi Sacco Hospital, Milan, Italy. The clinical characteristics all hospitalised early days epidemic (21 February -19 March 2020) were upon admission, time-dependent probability evaluated using Kaplan-Meier method (censored as 20 April...
Ischemic-reperfusion (I/R) injury induced a remodeling of protein and lipid homeostasis, under oxidative stress inflammatory status. Starvation occurring during I/R is condition leading to autophagy activation, which allows abnormal material clearance or amino acid, both, fatty acid (FA) recycling essential for survival. This study investigated the reshaping, peroxidation, related-signaling pathways, in rat brain endothelial cells (RBE4) subjected 3 h oxygen glucose deprivation (OGD)...
During the past three decades conflicting evidences have been published on use of non-invasive ventilation (NIV) in patients with acute cardiogenic pulmonary edema (ACPE). The aim this study is to describe management respiratory failure (ARF) due ACPE twelve Italian emergency departments (EDs). We evaluated prevalence, characteristics and outcomes treated oxygen therapy, continuous positive airway pressure (CPAP) or Bi-level (BiPAP) admission EDs. In multicenter, prospective, observational...